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Induced pluripotent stem cells
Russian Journal of Genetics, 2009Induced pluripotent stem cells (iPS) result from a reprogramming of somatic cells via transduction with viral vectors expressing the Oct4, Sox2, c-Myc, Klf4, Nanog, and Lin28 genes, which are essential for the establishment and maintenance of the pluripotent state. In properties, iPS are almost fully similar to embryonic stem cells (ESC).
A I, Shevchenko +3 more
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Cryobanking Pluripotent Stem Cells
2017Cryobanking human pluripotent stem cells (hPSCs), be they human embryonic (hESCs) or induced pluripotent stem cells (iPSCs), is essential for their use in research and cell-based therapeutics. Working and master cell banks can be generated with a desired level of quality assurance applied during cell freezing and storage. Conventional vitrification has
Crook, Jeremy Micah +2 more
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Pluripotent Stem Cell Heterogeneity
2019Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells, show heterogeneity with respect to their pluripotency, self-renewal ability, and other traits. PSC heterogeneity may exist among cell lines, among cells within a line, and among temporal states of individual cells.
Yohei, Hayashi +2 more
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Induced Pluripotent Stem Cells
2010Reprogramming of mouse and human somatic cells into induced pluripotent stem (iPS) cells has been possible with retroviral expression of the pluripotency-associated transcription factors Oct4, Sox2, Nanog, and Lin28 as well as Klf4 and c-Myc. iPS cells hold great potential as a model for diseases from the perspective of the individual patient and as an
Zaehres, Holm +2 more
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Pluripotent stem cells in rabbits.
2021International ...
Afanassieff, Marielle +4 more
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Pluripotency of embryonic stem cells
Cell and Tissue Research, 2007Embryonic stem (ES) cells derived from pre-implantation embryos have the potential to differentiate into any cell type derived from the three germ layers of ectoderm (epidermal tissues and nerves), mesoderm (muscle, bone, blood), and endoderm (liver, pancreas, gastrointestinal tract, lungs), including fetal and adult cells.
Yamanaka, S +7 more
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Adult-Derived Pluripotent Stem Cells
World Neurosurgery, 2014The global incidence of spinal cord injury (SCI) is 15-40 cases per million people, with the socioeconomic and healthcare costs amounting to nearly $10 billion per annum in the USA alone. Despite substantial advances in medical care and surgical technology, many patients with SCI still experience significant long-term neurologic disability.
Stuart D, Faulkner +2 more
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Science, 2008
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease.
John T. Dimos +12 more
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The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease.
John T. Dimos +12 more
semanticscholar +1 more source
Livestock Induced Pluripotent Stem Cells
Reproduction in Domestic Animals, 2012ContentsChimeric animals generated from livestock‐induced pluripotent stem cells (iPSCs) have opened the door of opportunity to genetically manipulate species for the production of biomedical models, improving traits of agricultural importance and potentially providing a system to test novel iPSC therapies.
Y, Lu, J L, Mumaw, F D, West, S L, Stice
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