Results 371 to 380 of about 962,530 (405)

The development of pluripotent stem cells

Current Opinion in Genetics & Development, 2012
Stem cell biology has many roots, and the current interest in the possible medical and pharmaceutical applications of pluripotent stem cells has far removed origins in the biology of a rare but peculiar type of tumor, the teratomas. The identification of their stem cells and their relationship to the early embryo paved the way, first in the mouse and ...
Paul J. Gokhale, Peter W. Andrews
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Pluripotent Stem Cell Heterogeneity

2019
Pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells, show heterogeneity with respect to their pluripotency, self-renewal ability, and other traits. PSC heterogeneity may exist among cell lines, among cells within a line, and among temporal states of individual cells.
Kiyoshi Ohnuma, Yohei Hayashi, Miho Furue   +2 more
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Pluripotent stem cells and their niches

Stem Cell Reviews, 2006
The ability of stem cells to self-renew and to replace mature cells is fundamental to ontogeny and tissue regeneration. Stem cells of the adult organism can be categorized as mono-, bi-, or multipotent, based on the number of mature cell types to which they can give rise.
M. William Lensch, Laurence Daheron, Thorsten M. Schlaeger, Thorsten M. Schlaeger   +3 more
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From pluripotent stem cells to T cells

Experimental Hematology, 2019
The generation of T cells from human pluripotent stem cells (PSCs) opens a valuable experimental window into developmental hematopoiesis and raises the possibility of a new therapeutic approach for T-cell immunotherapy. After directing PSCs through mesoderm and early hematopoietic developmental stages, commitment to the T-cell lineage has been achieved
Amélie, Montel-Hagen, Gay M, Crooks
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Pluripotent Stem Cells for Cell Therapy

2021
In an increasingly geriatric population, in which elderly people frequently face chronic diseases and degenerative conditions, cell therapies as part of novel regenerative medicine approaches are of great interest. Even though today's cell therapies mostly rely on adult stem cells like the mesenchymal stem cells or primary somatic cells, pluripotent ...
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Pluripotent Stem Cells

2014
Embryonic stem cells (ESCs) are pluripotent stem cells that are derived from early embryos. Induced pluripotent stem cells (iPSCs) are somatic cell-derived reprogrammed cells that have equivalent characteristics to ESCs. Disease-specific iPSCs have started to be used for the investigation of and development of the treatment for several diseases.
Takehiro Iki, Koji Nishimura, Tatsunori Sakamoto, Hiroe Ohnishi   +3 more
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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

Science, 2008
The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease.
John T. Dimos, Kit T. Rodolfa, K. Niakan, L. Weisenthal, H. Mitsumoto, Wendy K. Chung, Gist Croft, G. Saphier, R. Leibel, R. Goland, H. Wichterle, C. Henderson, K. Eggan   +12 more
semanticscholar   +1 more source

Chemical reprogramming of human somatic cells to pluripotent stem cells

Nature, 2022
Jingyang Guan, Guan Wang, Jinlin Wang, Zhengyuan Zhang, Yao Fu, Lin Cheng, G. Meng, Yulin Lyu, Jialiang Zhu, Yanqin Li, Yang Wang, Shi Liuyang, Bei Liu, Zirun Yang, Huanjing He, Xinxing Zhong, Qijing Chen, Xu Zhang, Shicheng Sun, Weifeng Lai, Yan Shi, Lulu Liu, Lipeng Wang, Cheng Li, Shichun Lu, Hongkui Deng   +25 more
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Blastocyst-like structures generated from human pluripotent stem cells

Nature, 2021
Leqian Yu, Yulei Wei, Jialei Duan, Daniel A. Schmitz, M. Sakurai, Lei Wang, Kunhua Wang, Shuhua Zhao, G. Hon, Jun Wu   +9 more
semanticscholar   +1 more source

Generation of Induced Pluripotent Stem Cells

2014
Induced pluripotent stem cells (iPSCs) are generated from somatic cells that have been reprogrammed by the ectopic expression of defined embryonic transcription factors. This technology has provided investigators with a powerful tool for modeling disease and developing treatments for human disorders.
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