Results 61 to 70 of about 201,548 (273)

Human induced pluripotent stem cells can reach complete terminal maturation: in vivo and in vitro evidence in the erythropoietic differentiation model

Haematologica, 2012
Background Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells ...
Ladan Kobari, Frank Yates, Noufissa Oudrhiri, Alain Francina, Laurent Kiger, Christelle Mazurier, Shaghayegh Rouzbeh, Wassim El-Nemer, Nicolas Hebert, Marie-Catherine Giarratana, Sabine François, Alain Chapel, Hélène Lapillonne, Dominique Luton, Annelise Bennaceur-Griscelli, Luc Douay   +15 more
doaj   +1 more source

Soft Pneumatic Device Designed to Mimic the Periosteal Environment for Regulating the Fate of Mesenchymal Stem Cells

Advanced Healthcare Materials, EarlyView.
This study presents a custom‐made soft pneumatic device (SPD) that mimics complex mechanical forces and fluid flow to enhance in vitro cell differentiation. It shows that low mechanotransduction promotes MSC differentiation into osteoprogenitor cells, while high mechanotransduction causes structural disruptions and cell detachment, providing new ...
Gwang‐Bum Im, Jae Gyeong Lee, Hosub Lim, Jae‐Won Lee, Hyun Su Park, Yongju Kim, Nauman Asad, Hak‐Rin Kim, Jeong Jae Wie, Suk Ho Bhang   +9 more
wiley   +1 more source

In Vivo‐Like Scaffold‐Free 3D In Vitro Models of Muscular Dystrophies: The Case for Anchored Cell Sheet Engineering in Personalized Medicine

Advanced Healthcare Materials, EarlyView.
The scaffold‐free Anchored Cell Sheet Engineering platform is used to create three‐dimensional (3D) in vitro models of skeletal muscle tissue that replicate key features of Duchenne and Myotonic dystrophies. These personalized tissue models, validated by histological, immunostaining, and proteomics analyses, accurately mimic disease phenotypes and ...
Alireza Shahin‐Shamsabadi, John Cappuccitti   +1 more
wiley   +1 more source

Pluripotent Stem Cells: Current Understanding and Future Directions

Stem Cells International, 2016
Pluripotent stem cells have the ability to undergo self-renewal and to give rise to all cells of the tissues of the body. However, this definition has been recently complicated by the existence of distinct cellular states that display these features ...
Antonio Romito, Gilda Cobellis
doaj   +1 more source

A Quantum Model on Chemically-Physically Induced Pluripotency in Stem Cells [PDF]

arXiv, 2013
A quantum model on the chemically and physically induced pluripotency in stem cells is proposed. Based on the conformational Hamiltonian and the idea of slow variables (molecular torsions) slaving fast ones the conversion from the differentiate state to pluripotent state is defined as the quantum transition between conformational states.
arxiv  

Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss

Advanced Healthcare Materials, EarlyView.
Volumetric muscle loss (VML) due to trauma or surgery, often leads to physical impairments. Traditional treatments rely on autologous flaps, limited by muscle availability often leading to donor site morbidity. This study presents multimodal bioprinting as an innovative approach for fabricating vascularized muscle flaps with 3D‐printed macrovessels ...
Eliana O. Fischer, Anna Tsukerman, Majd Machour, Margarita Shuhmaher, Asaf Silverstein, Maya Yaakov, Orit Bar‐Am, Lior Debbi, Shulamit Levenberg   +8 more
wiley   +1 more source

DNA Methylation Is Involved in the Expression of miR-142-3p in Fibroblasts and Induced Pluripotent Stem Cells

Stem Cells International, 2014
MicroRNAs are differentially expressed in cells and regulate multiple biological processes. We have been analyzing comprehensive expression patterns of microRNA in human and mouse embryonic stem and induced pluripotent stem cells. We determined microRNAs
Siti Razila Abdul Razak, Yukihiro Baba, Hiromitsu Nakauchi, Makoto Otsu, Sumiko Watanabe   +4 more
doaj   +1 more source

SILAC Proteomics of Planarians Identifies Ncoa5 as a Conserved Component of Pluripotent Stem Cells

Cell Reports, 2013
Planarian regeneration depends on the presence of pluripotent stem cells in the adult. We developed an in vivo stable isotope labeling by amino acids in cell culture (SILAC) protocol in planarians to identify proteins that are enriched in planarian stem ...
Alexander Böser, Hannes C.A. Drexler, Hanna Reuter, Henning Schmitz, Guangming Wu, Hans R. Schöler, Luca Gentile, Kerstin Bartscherer   +7 more
doaj   +1 more source

Design Principle of Gene Expression Used by Human Stem Cells; Implication for Pluripotency [PDF]

arXiv, 2004
Human embryonic stem cells (ESC) are undifferentiated and are endowed with the capacities of self renewal and pluripotential differentiation. Adult stem cells renew their own tissue, but whether they can trans-differentiate to other tissues is still controversial.
arxiv  

Organoid‐Like Neurovascular Spheroids Promote the Recovery of Hypoxic‐Ischemic Skin Flaps Through the Activation of Autophagy

Advanced Healthcare Materials, EarlyView.
Highly sprouting organoid‐like neurovascular spheroids (NVUs) are developed, featuring cell‐loaded poly‐3‐hydroxybutyrate 4‐hydroxybutyrate(P34HB) porous microsphere cores embedded within Gelatin Methacryloyl. NVUs formed complex vascular plexuses and secreted extracellular matrix in vitro, simulating autologous nerves and blood interaction.
Junjin Jie, Jingyi Ju, Zhenxing Wang, Jun Chen, Lin‐Ping Wu, Jiaming Sun   +5 more
wiley   +1 more source