Results 41 to 50 of about 8,831 (205)

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation

International Journal of Nanomedicine, 2013
Yanzuo Chen,1 Xianyi Sha,1 Wei Zhang,1,2 Weitong Zhong,1 Zhuoyang Fan,1 Qiuyue Ren,1 Liangcen Chen,1 Xiaoling Fang1 1Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University ...
Chen Y, Sha X, Zhang W, Zhong W, Fan Z, Ren Q, Chen L, Fang X   +7 more
doaj  

A novel transdermal honokiol formulation based on Pluronic F127 copolymer

Drug Delivery, 2010
This paper developed a new hydrophobic honokiol transdermal delivery system. First, Honokiol was loaded into Pluronic F127 micelles by direct dissolution method assisted by ultrasound. Then the obtained honokiol-loaded F127 micelles were incorporated into thermosensitive F127 hydrogel, which made the composite system bioadhesive.
XiuLing, Zheng, XiuHong, Wang, MaLing, Gou, Juan, Zhang, Ke, Men, LiJuan, Chen, Feng, Luo, Xia, Zhao, YuQuan, Wei, ZhiYong, Qian   +9 more
openaire   +2 more sources

Sunscreen‐Inspired Nano‐Pesticide for UV‐Shielding and Laccase‐Responsive Delivery of Mancozeb With Enhanced Fungicidal Efficacy and Ecological Safety

Advanced Science, EarlyView.
The sunscreen‐inspired nano‐pesticide, MCB@URFSL, provides UV‐shielding, enhanced rainfastness, and laccase‐responsive delivery for improved fungicidal efficacy and high ecological safety. ABSTRACT Fungicides are a crucial tool for protecting crops and ensuring consistent food supply.
Jin Yan, Xin Ye, Linping He, Cheng Hong, Xu‐Huan Zhao, Gizachew Mulugeta Manahelohe, Xiao‐Tong Feng, Yu‐Cheng Gu, Qiang Bian, Min Wu, Ming‐Zhi Zhang   +10 more
wiley   +1 more source

Novel Ultrasound-Responsive Amyloid Formulation

Pharmaceuticals
Amyloid aggregates have attracted significant interest in regard to diverse biomedical applications, particularly in the field of drug delivery. Here, we report novel amyloid aggregates based on a 12-amino-acid peptide from the amyloidogenic region of ...
Maytham Ismail, Mathumai Kanapathipillai
doaj   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Effect of Modifier Agents on Particle Size and Surface Functional Groups of Calcined Eggshell: Test in Adsorption of Remazol Yellow

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2020
Calcined eggshell (CES) was modified with Pluronic 123 (P123), Pluronic 127 (F127) and polyethylene glycol(PEG) agents and used in adsorption of Remazol Yellow.
Filiz Akti
doaj   +1 more source