Results 81 to 90 of about 8,831 (205)

Redox-responsive F127-folate/F127-disulfide bond-D-α-tocopheryl polyethylene glycol 1000 succinate/P123 mixed micelles loaded with paclitaxel for the reversal of multidrug resistance in tumors

open access: yesInternational Journal of Nanomedicine, 2018
Jing Lin,* Chaoyue Zhao,* Cuijuan Liu, Shiyao Fu, Luying Han, Xinping Lu, Chunrong Yang College of Pharmacy, Jiamusi University, Jiamusi, Heilongjiang, China *These authors contributed equally to this work Introduction: The development of nanodrug ...
Lin J   +6 more
doaj  

Practically Error‐Free Junctions Enable Solving Large Instances of Exact Cover Problems Using Network‐Based Biocomputation

open access: yesSmall, EarlyView.
Scaling nanofluidic channel geometries to sub‐200 nm is demonstrated to suppress junction guiding errors in network‐based biocomputing. The resulting increase in path fidelity enables experimental solution of Exact Cover instances with more than 33 million possible solutions, establishing a new benchmark for network‐based biocomputing. ABSTRACT Network‐
Eugene Christo V R   +8 more
wiley   +1 more source

Olmesartan medoxomil-loaded mixed micelles: Preparation, characterization and in-vitro evaluation

open access: yesFuture Journal of Pharmaceutical Sciences, 2017
Olmesartan medoxomil (OLM) is highly lipophilic in nature (log p = 4.31) which attributes to its low aqueous solubility contributing to its low bioavailability 25.6%.
Mohamed A. El-Gendy   +3 more
doaj   +1 more source

Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems

open access: yesSmall, EarlyView.
This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li   +3 more
wiley   +1 more source

Multi‐Scale 3D Printing of Magnetic Polymer Nanocomposites with Controlled Particle Dispersion and Hyperthermic Response

open access: yesSmall, EarlyView.
Dispersion of magnetic nanoflowers in trimethylolpropane ethoxylate triacrylate to generate photocurable nanocomposites is described. Particle dispersion provides processability and target AC‐field stimulated temperature increases. Complex (DLP) printed structures with submicron features are demonstrated, and the potential for stimulated release of ...
Eoin P. McKiernan   +9 more
wiley   +1 more source

Effect of Pluronic F127 Concentration on Gelling Temperature and other Parameters of Lomustine Mucoadhesive In-Situ Gel

open access: yesIraqi Journal of Pharmaceutical Sciences
Pluronic F127 is one of the widely used thermoreversible gelling agent, and used in sol-to-gel transformation. It has been used to localize drug delivery such as nose-to-brain delivery which allows the direct targeting of drug molecules bypassing the ...
Maryam H. Alaayedi   +1 more
doaj   +1 more source

Programmable Porosity in Polymers via Microfluidic Templating and 3D Printing

open access: yesSmall Methods, EarlyView.
Fluid templating is a powerful way to produce porous polymers. Microfluidic technologies enable fine control over the dimension and packing of bubbles and droplets. Combined with additive manufacturing, microfluidic templating enables the creation of polymeric functionally graded porous materials in which both porosity and three‐dimensional geometry ...
Federico Serpe   +3 more
wiley   +1 more source

Ginsenoside Rg3 micelles mitigate doxorubicin-induced cardiotoxicity and enhance its anticancer efficacy

open access: yesDrug Delivery, 2017
Doxorubicin (DOX) is one of the most effective chemotherapy agents used in the treatment of hematological and solid tumors, however, it causes dose-related cardiotoxicity that may lead to heart failure in patients.
Lan Li   +12 more
doaj   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

open access: yesThe FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List   +2 more
wiley   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

open access: yesPeriodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

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