Results 41 to 50 of about 2,789 (155)

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

Optimization of Preservation Methods Provides Insights into Photosynthetic Picoeukaryotes in Lakes

Microbiology Spectrum, 2022
As the key contributor to plankton biomass and nutrient cycling in aquatic ecosystems, photosynthetic picoeukaryotes (PPEs) have been recently investigated in freshwater ecosystems.
Changqing Liu, Jin Lei, Min Zhang, Fan Wu, Mingdong Ren, Jinsheng Yang, Qinglong Wu, Xiaoli Shi   +7 more
doaj   +1 more source

The Maintenance of Dysmyelinated Small‐Diameter Axons by 14‐3‐3s in the Central Nervous System

Glia, Volume 74, Issue 11, November 2026.
Dysmyelinated small‐diameter axons are maintained in teneurin‐4 deficient mice at the age of 1 year, while axonal damage is observed. 14‐3‐3s are highly expressed and suppress the progression of the damage in these axons. ABSTRACT In the central nervous system, myelin formed around nerve axons by oligodendrocyte enables efficient conduction of action ...
Nanako Yamada, Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Binri Sasaki, Momona Yamada, Sakurako Abe, Chikako Hayashi, Akira Yoshimoto, Ryunosuke Ohkawa, Tomal Julian Matt, Florence M Bareyre, Stefan Berghoff, Mikael Simons, Nobuharu Suzuki   +15 more
wiley   +1 more source

Bioreactor Microcarrier Cell Culture System (Bio-MCCS) for Large-Scale Production of Autologous Melanocytes

Cell Transplantation, 2004
Restoration of cutaneous pigmentation can be achieved in stable vitiligo by autologous cultured melanocyte transplantation. It was the goal of this study to construct a bioreactor microcarrier cell culture system (Bio-MCCS) to produce autologous ...
Jin Yu Liu, Jürg Hafner, Galya Dragieva, Günter Burg   +3 more
doaj   +1 more source

DEVELOPMENT OF ORAL NIFEDIPINE-LOADED POLYMERIC NANOCAPSULES: PHYSICOCHEMICAL CHARACTERISATION, PHOTOSTABILITY STUDIES, IN VITRO AND IN VIVO EVALUATION

Química Nova, 2015
In this study, nifedipine (NFP)-loaded polymeric nanocapsules were prepared and characterised with a view to protect the drug from degradation. Nanocapsule suspensions were prepared using two different surfactants (pluronic F68 and polyvinyl alcohol ...
Monika Piazzon Tagliari, Andrea Granada, Marcos Antonio Segatto Silva, Hellen Karine Stulzer, Betina Giehl Zanetti-Ramos, Daniel Fernandes, Izabella Thais Silva, Claudia Maria Oliveira Simões, Regina Sordi, Jamil Assreuy, Valdir Soldi   +10 more
doaj   +1 more source

Nanoprobe‐Enabled Precision Imaging and Panoramic Boundary Delineation in Retinoblastoma

Cancer Innovation, Volume 5, Issue 5, October 2026.
This review highlights that nanoprobe‐enabled multimodal imaging, combined with targeted probe design and AI‐assisted analysis, significantly enhances the precise visualization and boundary delineation of retinoblastoma. It further outlines key challenges and directions for translating high‐performance imaging nanoprobes into clinical practice.
Xuefei He, Precious Amarachi Ikwuagwu, Wenjing Pang, Aomen Chen, Lingchao Xiang, Feng Chen, Chen Xu, Aiguo Wu   +7 more
wiley   +1 more source

Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors

Bioactive Materials, 2022
Systemic chemotherapy has lost its position to treat cancer over the past years mainly due to drug resistance, side effects, and limited survival ratio.
A. Khodaei, F. Jahanmard, H.R. Madaah Hosseini, R. Bagheri, A. Dabbagh, H. Weinans, S. Amin Yavari   +6 more
doaj   +1 more source

Crystallization in Poly(Ethylene Oxide) Thin Films: Roles of Shear, Confinement, and Homoepitaxy

Macromolecular Rapid Communications, Volume 47, Issue 19, 6 October 2026.
A comprehensive three‐mechanism framework governing PEO crystallization orientation in thin films was established using GIWAXS and molecular‐level PM‐IRRAS analysis. We demonstrate systematic switching between shear‐induced edge‐on and confinement‐ or homoepitaxy‐induced flat‐on alignment.
Cong Liu, Sinan Feng, Shuntaro Uenuma, Atsushi Takahara, Kohzo Ito   +4 more
wiley   +1 more source

Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice [PDF]

British Journal of Cancer, 2001
Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed
Parnaud, G., Taché, Sylviane, Peiffer, G., Corpet, Denis E.   +3 more
openaire   +5 more sources

Ratiometric pH‐Responsive and Biomimetic Microparticles for Quantitative Monitoring of Phagosomal Acidification

Chemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
A series of hydrosoluble BODIPY pH probes allows building biomimetic pH sensors based on micrometric oil‐in‐water droplets. The ratiometric fluorescence output offers quantitative information on the evolution of pH during phagosome maturation. ABSTRACT We present a modular biomimetic fluorescent sensing platform designed to precisely interrogate the ...
Sophie Michelis, Héloïse Uhl, Florence Niedergang, Jacques Fattaccioli, Blaise Dumat, Jean‐Maurice Mallet   +5 more
wiley   +1 more source