Results 31 to 40 of about 2,789 (155)

New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate

Molecules, 2016
As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge.
Malwina Lachowicz, Michał Kołodziejczyk, Marek Lukosek, Jacek Kosno, Paulina Olszewska, Paweł Szymański   +5 more
doaj   +1 more source

Synthesis, characterization and anti-cancer activity of Pluronic F68–curcumin conjugate micelles [PDF]

Drug Delivery, 2015
Curcumin (CUR), a nontoxic polyphenol derived from the rhizome of turmeric (Curcuma longa), has been recognized as an anti-cancer and chemo-preventative agent. However, its clinical application for cancer treatment has been greatly limited due to its poor water-solubility and low bioavailability.
Yuee, Cai, Zhongqing, Sun, Xiaobin, Fang, Xiefan, Fang, Fei, Xiao, Yitao, Wang, Meiwan, Chen   +6 more
openaire   +2 more sources

Optimized Chitosan-Coated Gliadin Nanoparticles Improved the Hesperidin Cytotoxicity over Tumor Cells

Brazilian Archives of Biology and Technology, 2021
Hesperidin is a natural compound which is found in citric fruits and presents antitumor and antimicrobial activities. However, the in vivo efficacy of Hesperidin is reduced due to its low oral bioavailability.
Irineo Kelte Filho, Christiane Schineider Machado, Camila Diedrich, Thaysa Ksiaskiewcz Karam, Celso Vataru Nakamura, Najeh Maissar Khalil, Rubiana Mara Mainardes   +6 more
doaj   +1 more source

Effect of Pluronic F68 on Growth of Fibroblasts in Suspension on Rotary Shaker

Experimental Biology and Medicine, 1960
SummaryA medium composed of the defined solution S103 supplemented with 20% horse serum yields a noncellular precipitate when agitated on a rotary shaker. This precipitation results in loss of from 25 to 100% of growth-promoting activity of the medium for strain U12-29 fibroblasts in shake cultures.
H E, SWIM, R F, PARKER
openaire   +2 more sources

Chemical stabilization of dispersed Escherichia coli for enhanced recovery with a handheld electroflotation system and detection by Loop-mediated Isothermal AMPlification.

PLoS ONE, 2021
Constraints related to sample preparation are some of the primary obstacles to widespread deployment of molecular diagnostics for rapid detection of trace quantities (≤103 CFU/mL) of food-borne pathogens.
Lena Diaz, Yong Li, Daniel M Jenkins
doaj   +1 more source

Microfluidic Technology for the Production of Hybrid Nanomedicines

Pharmaceutics, 2021
Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control variables, such as the flow rate ratio,
Ilaria Ottonelli, Jason Thomas Duskey, Arianna Rinaldi, Maria Vittoria Grazioli, Irene Parmeggiani, Maria Angela Vandelli, Leon Z. Wang, Robert K. Prud’homme, Giovanni Tosi, Barbara Ruozi   +9 more
doaj   +1 more source

A Novel Docetaxel-Loaded Poly (ε-Caprolactone)/Pluronic F68 Nanoparticle Overcoming Multidrug Resistance for Breast Cancer Treatment

Nanoscale Research Letters, 2009
Multidrug resistance (MDR) in tumor cells is a significant obstacle to the success of chemotherapy in many cancers. The purpose of this research is to test the possibility of docetaxel-loaded poly (ε-caprolactone)/Pluronic F68 (PCL/Pluronic F68 ...
Chen Hongli, Tian Ge, Tian Yan, Liu Kexin, Li Zhen, Song Cunxian, Sun Hongfan, Mei Lin, Zhang Yangqing, Zheng Yi, Yang Dongye, Huang Laiqiang   +11 more
doaj   +1 more source

Preclinical development of carrier-free prodrug nanoparticles for enhanced antitumor therapeutic potential with less toxicity

Journal of Nanobiotechnology, 2022
Background Nanomedicine has emerged as a promising strategy for cancer treatment. The most representative nanomedicine used in clinic is PEGylated liposomal doxorubicin DOXIL®, which is first FDA-approved nanomedicine. However, several shortcomings, such
Man Kyu Shim, Suah Yang, Jooho Park, Jun Sik Yoon, Jinseong Kim, Yujeong Moon, Nayeon Shim, Mihee Jo, Yongwhan Choi, Kwangmeyung Kim   +9 more
doaj   +1 more source

Laser‐Synthesized Carbon‐Coated Elemental Bismuth Nanoparticles for Sustained Reactive Oxygen Species Generation Under Visible‐Light Irradiation

Small, EarlyView.
Femtosecond laser ablation of bismuth in acetone yields carbon‐coated nanoparticles with a metallic Bi0 core and an amorphous carbon shell. The core‐shell architecture preserves visible‐light‐driven redox activity and enables sustained hydroxyl‐radical generation.
Pavel Bezrukov, Sravan Sangeeth Surendran, Andrey Machnev, Andrei Pastukhov, Alexander Gumennik, Andrei Kabashin, Pavel Ginzburg   +6 more
wiley   +1 more source

Mesoporous N,S‐Dual‐Doped Carbon Nanoreactors via Entropy‐Driven Interface Self‐Assembly for Efficient H2O2 Electrosynthesis

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
An entropy‐driven interface self‐assembly strategy is proposed for the controllable synthesis of mesoporous N,S‐dual‐doped carbon nanoreactors. The N,S‐dual‐doping sites optimized the *OOH adsorption, boosting the 2e− selectivity, while the favorable mesostructure accelerated O2 enrichment.
Fei Liu, Xiaoqing Liu, Rui Zhang, Linxia Cui, Ji Liang, Rui Gao, Jian Liu   +6 more
wiley   +2 more sources