Results 231 to 240 of about 74,938 (343)

Structural dynamics and pH‐regulated membrane binding of the TRAF2‐NC trimer

open access: yesProtein Science, Volume 35, Issue 11, November 2026.
Abstract Tumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key adaptor in TNF receptor‐signaling that operates as a trimeric assembly. Here we investigate the structural and functional properties of a TRAF2 construct spanning the trimerization and receptor‐binding domains (TRAF2‐NC, residues 266–501).
Federica Cossu   +9 more
wiley   +1 more source

Assessment of the Binding Affinity of Covalent Inhibitors of Cruzain and Cathepsin L Using Relative Binding Free Energy

open access: yesChemMedChem, Volume 21, Issue 19, 14 October 2026.
Six nitrile‐based covalent inhibitors are evaluated against cruzain and hCatL. Thermodynamic integration accurately predicts relative binding affinities by modeling the covalent adduct state. We identify a structural difference in the S2 subsite that governs ligand selectivity, offering valuable insights for drug discovery.
Yan Carvalho Magno   +4 more
wiley   +1 more source

La PME tunisienne

open access: yes, 1998
Pierre-Noël Denieuil   +1 more
openaire   +1 more source

Editorial: Perspectives on Theory and Methods. [PDF]

open access: yesPerspect Med Educ
Wiese A   +3 more
europepmc   +1 more source

Gender-Specific Cancer-Related Survival Analysis of Robotic Versus Laparoscopic Low Anterior Resection for Rectal Adenocarcinoma: A Multicenter Study. [PDF]

open access: yesInt J Med Robot
Benlice C   +9 more
europepmc   +1 more source

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