Results 251 to 260 of about 74,938 (343)

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

open access: yesAdvanced Science, Volume 13, Issue 56, 9 October 2026.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li   +9 more
wiley   +1 more source

Towards a Standard Threshold for Genome Wide Significance in Dogs

open access: yesAnimal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Genome‐wide association studies (GWAS) are a foundational step in tying phenotype to genotype, relying on statistical significance thresholds to distinguish true‐ from false‐positive signals of association. Dog genomics has long relied on per‐study Bonferroni thresholds of significance, basing these on SNP chip levels of markers (~100 k to ...
Mats E. Pettersson   +2 more
wiley   +1 more source

ZBP1‐mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Metabolic stress increases Alzheimer's disease (AD) risk, but mechanisms linking metabolic dysfunction to neuroimmune dysregulation remain unclear. METHODS We assessed cognition in community‐dwelling participants and used high‐fat diet (HFD)‐fed 5xFAD mice, high glucose and high palmitate (HGHP)‐treated regulatory T cell (Treg) co‐
Shanshan Huang   +11 more
wiley   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, Volume 78, Issue 10, Page 2074-2081, October 2026.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo   +9 more
wiley   +1 more source

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