Results 51 to 60 of about 45,602 (296)

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Malaria Test, Treat and Track policy implementation in Angola: a retrospective study to assess the progress achieved after 4 years of programme implementation

Malaria Journal, 2020
Background Malaria is one of the main causes of death in Angola, particularly among children under 5 years of age. An essential means to improve the situation is with strong malaria case management; this includes diagnosing suspected patients with a ...
Sergio C. Lopes, Rukaaka Mugizi, João Esteves Pires, Fernando David, José Martins, Pedro Rafael Dimbu, Filomeno Fortes, Joana Rosário, Richard Allan   +8 more
doaj   +1 more source

Dimensional Engineering of Carbon‐Based Hybrids: From 1D Conductive Networks to 3D Porous Architectures for Next‐Generation Microwave Absorption

Advanced Science, EarlyView.
This review explores dimensional architecture engineering to overcome the impedance‐attenuation trade‐off in electromagnetic wave absorbing materials. By analyzing 1D to 3D structures and their multidimensional hybrids, we highlight synergistic mechanisms for enhanced performance.
Chuanyu Liu, Xiaoxin Guo, Xunlong Zhang, Ruiling Sun, Xingyu Zhang, Can Ge, Xuhong Yang, Yuqing Liu   +7 more
wiley   +1 more source

Equipo de gestión de reclamaciones contractuales como componente de gobernanza de los proyectos de infraestructura energética en Colombia

Informador Técnico, 2021
Los proyectos de infraestructura energética en Colombia presentan reclamaciones contractuales de manera constante. Tradicionalmente, el equipo del proyecto y su director son los encargados de atender estas reclamaciones, sin que sean expertos en temas ...
David Marmolejo-Carrazco, Abel Del Rio-Cortina   +1 more
doaj   +1 more source

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, EarlyView.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source

Identifying and characterizing high-risk populations in pilot malaria elimination districts in Madagascar: a mixed-methods study

Malaria Journal
Background In Madagascar, the districts of Antsirabe II, Faratsiho and Antsiranana I have relatively low malaria incidence rates and have been selected by the National Malaria Control Programme for pilot elimination strategies.
Elisabeth Gebreegziabher, Andry Raoliarison, Andrinirina Ramananjato, Andriamamonjy Fanomezana, Martin Rafaliarisoa, Sandy Ralisata, Jocelyn Razafindrakoto, Jennifer L. Smith, Jehan Ahmed, Cara Smith Gueye   +9 more
doaj   +1 more source

Administración del ciclo de vida de un proyecto de sistemas de información para una empresa de desarrollo de sistemas web utilizando la metodología pmi [PDF]

, 2014
La competitividad en el mundo cada vez es mayor y crece de manera acelerada en las organizaciones, una importante herramienta clave es la correcta gestión de proyectos.
Morán Cerezo, Walter Javier, Buri Gonzalez, Galo Alejandro   +1 more
core  

Supporting evidence-based analysis for modified risk tobacco products through a toxicology data-sharing infrastructure [version 2; referees: 2 approved]

F1000Research, 2017
The US FDA defines modified risk tobacco products (MRTPs) as products that aim to reduce harm or the risk of tobacco-related disease associated with commercially marketed tobacco products.
Stéphanie Boué, Thomas Exner, Samik Ghosh, Vincenzo Belcastro, Joh Dokler, David Page, Akash Boda, Filipe Bonjour, Barry Hardy, Patrick Vanscheeuwijck, Julia Hoeng, Manuel Peitsch   +11 more
doaj   +1 more source

The forgotten tale of spontaneous plateau pressure

Journal of Mechanical Ventilation, 2023
This article highlights the significance of measuring plateau pressure in spontaneously breathing patients as it provides valuable information about PMI (Pmusc Index), which serves as a surrogate for the patient's efforts during mechanical ventilation.
Abhijeet Anand
doaj   +1 more source

Sappanwood extract modulates hepatic structure–function in hepatomegaly and hepcidin related iron regulatory pathways in a phenylhydrazine induced hemolytic anemia rat model relevant to thalassemia

Animal Models and Experimental Medicine, EarlyView.
Phenylhydrazine (PHZ) induces hemolytic anemia characterized by increased erythrocyte destruction and ineffective erythropoiesis, leading to hepcidin suppression through disruption of the BMP/SMAD signaling pathway. Reduced hepcidin levels enhance intestinal iron absorption and hepatic iron accumulation, leading to hepatic iron overload.
Mohammad Indra Pratama, Ratu Safitri, Desak Made Malini, Mas Rizky A. A. Syamsunarno, Mohammad Ghozali, Madihah Madihah   +5 more
wiley   +1 more source