Results 41 to 50 of about 45,602 (296)

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, EarlyView.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources

Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds (r‐mS): A Platform for Metallodrug Discovery

Angewandte Chemie, EarlyView.
Re‐envisioning the Ligandable Proteome: Reactive Metallo‐Scaffolds (r‐mS) combine non‐covalent protein engagement by a metallo‐scaffold with covalent cysteine capture through a tethered chloroacetamide warhead. Chemoproteomic profiling reveals unique enzyme engagement including ligases, kinases and methyltransferases, highlighting opportunities for ...
Jessica E. Waters, Harry Wilders, George S. Biggs, Mika Kintzel, Emma E. Cawood, Jonathan Bailey, Sarah Maslen, Yew Mun Yip, Mason Wakley, Ioannis G. Riziotis, Thomas W. Rees, Joanna Redmond, J. Mark Skehel, David House, Jacob Bush, Jeannine Hess   +15 more
wiley   +2 more sources

A Perspective on the Applications of Triphasic Gas Storage in Electrochemical Systems

Advanced Science, EarlyView.
Gas storage in microporous materials positioned locally at an electrode or electrocatalyst surface enhances electrochemical processes. Abstract Microporous materials store gases under dry conditions (e.g., hydrogen or oxygen via physisorption), but in some cases microporous materials also show triphasic (e.g., in a solid|gas|liquid system) gas storage ...
Zhongkai Li, Corin T. Scott, Taku Suzuki‐Osborne, John P. Lowe, Dominic Taylor, Mariolino Carta, Neil B. McKeown, Andrew D. Burrows, Lucia H. Mascaro, Frank Marken   +9 more
wiley   +1 more source

POLITICAL CAMPAIGNING AND PROPAGANDA ON TELEVISION: FEATURES OF USE

Вісник Харківського національного університету імені В. Н. Каразіна: Серія "Питання політології", 2023
The topic of political campaigning and propaganda on television is highlighted with an emphasis on methods, effectiveness and ethical aspects of influencing public opinion and political processes.
Maksym Honcharenko
doaj   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

Sostenibilità e PMI: Aspetti strategici, operativi e finanziari [PDF]

, 2022
Le PMI costituiscono il perno del sistema economico-industriale italiano e sono un attore fondamentale nelle dinamiche sociali e di comunità. Rappresentano il 99% delle imprese del nostro Paese, l’80% dell’occupazione e il 67% del valore aggiunto ...
Leonardo Boni, Marco Letizi, Pasqualina Porretta, Francesco Perrini, Carlo Bellavite Pellegrini, Stefania Zanda, Adriano Cerocchi, Mario Calderini   +7 more
core  

Determination of Clostridium perfringenes in the Liver of Women and Men after Death as an Indicator for Postmortem Interval

Armaghane Danesh Bimonthly Journal, 2021
Background & aim: Most medical research to estimate the time interval after death depends on the physicochemical properties of the decomposition and the effects that environmental factors have on the decomposition process, but microorganisms settle in ...
N Bahador, M Keyani
doaj  

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

Favorire la transizione sostenibile delle PMI: la prospettiva dei business leader di grandi imprese [PDF]

, 2022
Introduzione - Metodologia di ricerca - Principali evidenze emerse - Il contesto attuale - La prospettiva dei business leader riguardo all’adozione di modelli sostenibili per le PMI - Principali ambiti di azione per le PMI ...
De Silvio, Manlio, Perrini, Francesco, Stoppani, Oddone, Minichilli, Alessandro, Pogutz, Stefano   +4 more
core  

Blood and urine multi-omics analysis of the impact of e-vaping, smoking, and cessation: from exposome to molecular responses

Scientific Reports
Cigarette smoking is a major preventable cause of morbidity and mortality. While quitting smoking is the best option, switching from cigarettes to non-combustible alternatives (NCAs) such as e-vapor products is a viable harm reduction approach for ...
Carine Poussin, Bjoern Titz, Yang Xiang, Laurel Baglia, Rachel Berg, David Bornand, Mohammed-Amin Choukrallah, Timothy Curran, Sophie Dijon, Eric Dossin, Remi Dulize, Doris Etter, Maria Fatarova, Loyse Felber Medlin, Adrian Haiduc, Edina Kishazi, Aditya R. Kolli, Athanasios Kondylis, Emmanuel Kottelat, Csaba Laszlo, Oksana Lavrynenko, Yvan Eb-Levadoux, Catherine Nury, Dariusz Peric, Melissa Rizza, Thomas Schneider, Emmanuel Guedj, Florian Calvino, Nicolas Sierro, Philippe Guy, Nikolai V. Ivanov, Patrick Picavet, Sherry Spinelli, Julia Hoeng, Manuel C. Peitsch   +34 more
doaj   +1 more source