Results 1 to 10 of about 102,232 (247)

Casting a wide net: use of diverse model organisms to advance toxicology

Disease Models & Mechanisms, 2020
Toxicology – the study of how chemicals interact with biological systems – has clear relevance to human health and disease. Persistent exposure to natural and synthetic chemicals is an unavoidable part of living on our planet; yet, we understand very ...
Mark E. Hahn, Kirsten C. Sadler
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BAP1 in cancer: epigenetic stability and genome integrity

Discover Oncology, 2022
Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven ...
Sabrina Caporali, Alessio Butera, Ivano Amelio   +2 more
doaj   +1 more source

Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges

Journal of Nanotheranostics, 2023
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development.
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

The Serosal Immune System of the Thorax in Toxicology [PDF]

Toxicological Sciences, 2018
The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated lymphoid ...
Christine F Kuper, Jolanda van Bilsen, Marcel V W Wijnands   +2 more
openaire   +3 more sources

Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications

Journal of Nanotheranostics, 2023
A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Current Research in Toxicology, 2023
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not ...
Marie-Christin Jäger, Friedrich L. Joos, Denise V. Winter, Alex Odermatt   +3 more
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Insect in vitro System for Toxicology Studies — Current and Future Perspectives

Frontiers in Toxicology, 2021
In vitro cell culture practices are valuable techniques to understand the mechanisms behind vital in vivo biological processes. In vitro cells have helped us to attain a deeper understanding of functions and mechanisms conserved in the course of ...
Sheeja Cc, Damodaran Arun, Lekha Divya
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In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

Frontiers in Systems Biology
Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant in global aquatic ecosystems with increasing concern for its toxicity to aquatic wildlife through inadvertent exposures.
Rayna M. Nolen, Lene H. Petersen, Karl Kaiser, Karl Kaiser, Antonietta Quigg, Antonietta Quigg, Antonietta Quigg, David Hala   +7 more
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A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
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Identification of environmental etiologies of neurodevelopmental disorders in children

生物医学转化
Neurodevelopmental disorders (NDDs) are a group of chronic developmental brain dysfunctions caused by various genetic or acquired factors, characterized by high disability rates and a lack of effective treatments.
Li Yuanyuan
doaj   +1 more source