Proteomics for systems toxicology [PDF]
Computational and Structural Biotechnology Journal, 2014 Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment.
Bjoern Titz +7 more
doaj +6 more sources
Metabolomics- and systems toxicology-based hepatotoxicity mechanism of Sophorae Tonkinensis Radix et Rhizoma in rats [PDF]
Frontiers in Pharmacology, 2022 Drug-induced liver injury (DILI) is a major challenge to the development and clinical application of drugs, especially limits the global application of Chinese herbal medicines, because the material basis and mechanisms of some Chinese herbal medicines ...
Dengxiang Yu +5 more
doaj +2 more sources
Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish [PDF]
Frontiers in Genetics, 2021 Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li +9 more
doaj +2 more sources
Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach [PDF]
Antioxidants, 2021 Parkinson’s Disease (PD) is a neurodegenerative disease, leading to motor and non-motor complications. Autonomic alterations, including gastrointestinal symptoms, precede motor defects and act as early warning signs.
Lady Johanna Forero-Rodríguez +4 more
doaj +2 more sources
Casting a wide net: use of diverse model organisms to advance toxicology [PDF]
Disease Models & Mechanisms, 2020 Toxicology – the study of how chemicals interact with biological systems – has clear relevance to human health and disease. Persistent exposure to natural and synthetic chemicals is an unavoidable part of living on our planet; yet, we understand very ...
Mark E. Hahn, Kirsten C. Sadler
doaj +3 more sources
Quantitative systems toxicology. [PDF]
Curr Opin Toxicol, 2017 The overarching goal of modern drug development is to optimize therapeutic benefits while minimizing adverse effects. However, inadequate efficacy and safety concerns remain to be the major causes of drug attrition in clinical development. For the past 80 years, toxicity testing has consisted of evaluating the adverse effects of drugs in animals to ...
Bloomingdale P +6 more
europepmc +3 more sources
Systems toxicology unravels multi-tiered carcinogenic networks of zearalenone in gastric cancer [PDF]
Frontiers in OncologyIntroductionGastric cancer (GC) is a leading cause of cancer mortality worldwide, and dietary factors like mycotoxins play a significant role in its etiology.
Hangbin Zheng +12 more
doaj +2 more sources
Multi-scale systems toxicology defines a KLF5-centered adverse outcome pathway linking DEHP exposure to pancreatic cancer progression and signaling programs relevant to therapy tolerance [PDF]
Frontiers in Cell and Developmental BiologyDi(2-ethylhexyl) phthalate (DEHP) is a ubiquitous plasticizer implicated in pancreatic carcinogenesis, yet the molecular initiating events and adverse outcome pathways (AOPs) linking exposure to disease mechanisms remain poorly resolved.
Jihao Chen +5 more
doaj +2 more sources
Systems Toxicology: Real World Applications and Opportunities. [PDF]
Chem Res Toxicol, 2017 Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Hartung T +8 more
europepmc +4 more sources