Results 11 to 20 of about 108,508 (278)
Systems biology tools for toxicology [PDF]
Archives of Toxicology, 2012 An important goal of toxicology is to understand and predict the adverse effects of drugs and other xenobiotics. For pharmaceuticals, such effects often emerge unexpectedly in man even when absent from trials in vitro and in animals. Although drugs and xenobiotics act on molecules, it is their perturbation of intracellular networks that matters.
Geenen S +5 more
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An introduction to systems toxicology [PDF]
Toxicology Research, 2015 Systems toxicology combines novel and historical experimental data to generate increasingly complex models of the biological response to chemical exposure.
Plant, NJ
core +6 more sources
Systems bioengineering approaches for developmental toxicology
Computational and Structural Biotechnology Journal, 2023 Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the ...
Beatriz Xavier Soares +2 more
doaj +2 more sources
3S - Systematic, systemic, and systems biology and toxicology
ALTEX, 2018 A biological system is more than the sum of its parts - it accomplishes many functions via synergy. Deconstructing the system down to the molecular mechanism level necessitates the complement of reconstructing functions on all levels, i.e., in our conceptualization of biology and its perturbations, our experimental models and computer modelling ...
Smirnova, Lena +5 more
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Systems Toxicology: Real World Applications and Opportunities. [PDF]
Chem Res Toxicol, 2017 Systems Toxicology aims to change the basis of how adverse biological effects of xenobiotics are characterized from empirical end points to describing modes of action as adverse outcome pathways and perturbed networks. Toward this aim, Systems Toxicology
Hartung T +8 more
europepmc +2 more sources
Public data sources to support systems toxicology applications. [PDF]
Curr Opin Toxicol, 2019 Davis AP +3 more
europepmc +2 more sources
From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study
Frontiers in Toxicology, 2022 The last decade has seen the adverse outcome pathways (AOP) framework become one of the most powerful tools in chemical risk assessment, but the development of new AOPs remains a slow and manually intensive process. Here, we present a faster approach for
Živa Ramšak +5 more
doaj +1 more source
TOXPANEL: A Gene-Set Analysis Tool to Assess Liver and Kidney Injuries
Frontiers in Pharmacology, 2021 Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range.
Patric Schyman +6 more
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Assessing network-based methods in the context of system toxicology
Frontiers in Pharmacology, 2023 Introduction: Network-based methods are promising approaches in systems toxicology because they can be used to predict the effects of drugs and chemicals on health, to elucidate the mode of action of compounds, and to identify biomarkers of toxicity ...
Jordi Valls-Margarit +5 more
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Predictive Systems Toxicology [PDF]
, 2018 37 pages, 3 figures.
Kiani, Narsis A. +3 more
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