Results 11 to 20 of about 320,373 (282)
Functional toxicology: tools to advance the future of toxicity testing [PDF]
Frontiers in Genetics, 2014 The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often ...
Brandon David Gaytán, Chris eVulpe
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Systems Toxicology Approach to Identifying Paracetamol Overdose. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2018 Paracetamol (acetaminophen (APAP)) is one of the most commonly used analgesics in the United Kingdom and the United States. However, exceeding the maximum recommended dose can cause serious liver injury and even death.
Mason CL +5 more
europepmc +6 more sources
Systems Toxicology: The Future of Risk Assessment. [PDF]
Int J Toxicol, 2015 Risk assessment, in the context of public health, is the process of quantifying the probability of a harmful effect to individuals or populations from human activities. With increasing public health concern regarding the potential risks associated with chemical exposure, there is a need for more predictive and accurate approaches to risk assessment ...
Sauer JM +5 more
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Systems bioengineering approaches for developmental toxicology
Computational and Structural Biotechnology Journal, 2023 Developmental toxicology is the field of study that examines the effects of chemical and physical agents on developing organisms. By using principles of systems biology and bioengineering, a systems bioengineering approach could be applied to study the ...
Beatriz Xavier Soares +2 more
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In Vitro Toxicology Systems [PDF]
, 2014 In vitro toxicology systems , In vitro toxicology systems , کتابخانه مرکزی دانشگاه علوم پزشکی ...
Leonard, Martin O +2 more
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From prediction to adaptation: rethinking the epistemic role of inhalation toxicology [PDF]
Frontiers in ToxicologyInhalation toxicology has long aimed to predict the health effects of airborne substances before exposure occurs, relying on stable dose-response relationships and well-characterized hazards.
Samir Dekali
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From Causal Networks to Adverse Outcome Pathways: A Developmental Neurotoxicity Case Study
Frontiers in Toxicology, 2022 The last decade has seen the adverse outcome pathways (AOP) framework become one of the most powerful tools in chemical risk assessment, but the development of new AOPs remains a slow and manually intensive process. Here, we present a faster approach for
Živa Ramšak +5 more
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TOXPANEL: A Gene-Set Analysis Tool to Assess Liver and Kidney Injuries
Frontiers in Pharmacology, 2021 Gene-set analysis is commonly used to identify trends in gene expression when cells, tissues, organs, or organisms are subjected to conditions that differ from those within the normal physiological range.
Patric Schyman +6 more
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Assessing network-based methods in the context of system toxicology
Frontiers in Pharmacology, 2023 Introduction: Network-based methods are promising approaches in systems toxicology because they can be used to predict the effects of drugs and chemicals on health, to elucidate the mode of action of compounds, and to identify biomarkers of toxicity ...
Jordi Valls-Margarit +5 more
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Systems biology meets toxicology [PDF]
Archives of Toxicology, 2012 In this issue of the Archives of Toxicology, Hans Westerhoff and colleagues present a comprehensive review on how systems biology tools can be applied to toxicology (Geenen et al. 2012; this issue). For decades, scientists in the field of toxicology have taken advantage of available mathematical models.
R, Marchan, H M, Bolt, J G, Hengstler
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