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Systems toxicology: from basic research to risk assessment. [PDF]
Chem Res Toxicol, 2014 Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization. Society demands increasingly close scrutiny of the
Sturla SJ +8 more
europepmc +2 more sources
ALTEX, 2012 The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries.
Thomas, Hartung +5 more
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Systems biology meets toxicology [PDF]
Archives of Toxicology, 2012 In this issue of the Archives of Toxicology, Hans Westerhoff and colleagues present a comprehensive review on how systems biology tools can be applied to toxicology (Geenen et al. 2012; this issue). For decades, scientists in the field of toxicology have taken advantage of available mathematical models.
R, Marchan, H M, Bolt, J G, Hengstler
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Network-Based Methods for Prediction of Drug-Target Interactions
Frontiers in Pharmacology, 2018 Drug-target interaction (DTI) is the basis of drug discovery. However, it is time-consuming and costly to determine DTIs experimentally. Over the past decade, various computational methods were proposed to predict potential DTIs with high efficiency and ...
Zengrui Wu +3 more
doaj +1 more source
Casting a wide net: use of diverse model organisms to advance toxicology
Disease Models & Mechanisms, 2020 Toxicology – the study of how chemicals interact with biological systems – has clear relevance to human health and disease. Persistent exposure to natural and synthetic chemicals is an unavoidable part of living on our planet; yet, we understand very ...
Mark E. Hahn, Kirsten C. Sadler
doaj +1 more source
In silico toxicology: An overview of toxicity databases, prediction methodologies, and expert review
, 2022 S.209-242Understanding chemical toxicity is a necessary part of the R&D and regulatory approval process across many industries (e.g. pharmaceuticals, cosmetics, and pesticides).
Escher, Sylvia E. +4 more
core +1 more source
Systems Toxicology Approach for Testing Chemical Cardiotoxicity in Larval Zebrafish
, 2022 S.2550-2564Transcriptomic approaches can give insight into molecular mechanisms underlying chemical toxicity and are increasingly being used as part of toxicological assessments.
Belcastro, Vincenzo +10 more
core +1 more source
Non-precautionary aspects of toxicology [PDF]
, 2018 Empirical studies in toxicology aim at deciphering complex causal relationships, especially in regard to human disease etiologies. Several scientific traditions limit the usefulness of documentation from current toxicological research, in regard to ...
Grandjean, Philippe
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BAP1 in cancer: epigenetic stability and genome integrity
Discover Oncology, 2022 Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven ...
Sabrina Caporali +2 more
doaj +1 more source
The Serosal Immune System of the Thorax in Toxicology [PDF]
Toxicological Sciences, 2018 The thoracic cavities receive increasing attention in toxicology, because inhaled fibers and (nano)particles can reach these cavities and challenge the local lymphoid tissues. The thoracic and abdominopelvic cavities are controlled by the serosal immune system with its special, loosely organized lymphoid clusters, namely the fat-associated lymphoid ...
Christine F Kuper +2 more
openaire +3 more sources