Results 21 to 30 of about 320,373 (282)
Predictive Systems Toxicology [PDF]
, 2018 37 pages, 3 figures.
Kiani, Narsis A. +3 more
openaire +3 more sources
ALTEX, 2012 The need for a more mechanistic understanding of the ways in which chemicals modulate biological pathways is urgent if we are to identify and better assess safety issues relating to a wide range of substances developed by the pharmaceutical, chemical, agri-bio, and cosmetic industries.
Thomas, Hartung +5 more
openaire +3 more sources
Network-Based Methods for Prediction of Drug-Target Interactions
Frontiers in Pharmacology, 2018 Drug-target interaction (DTI) is the basis of drug discovery. However, it is time-consuming and costly to determine DTIs experimentally. Over the past decade, various computational methods were proposed to predict potential DTIs with high efficiency and ...
Zengrui Wu +3 more
doaj +1 more source
Systems biology and synthetic biology: A new epoch for toxicology research [PDF]
, 2014 Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Choi, Hyunok +4 more
core +7 more sources
Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action [PDF]
, 2014 Summary The Human Toxicology Project Consortium (HTPC) was created to accelerate implementation of the science and policies required to achieve a pathway-based foundation for toxicology as articulated in the 2007 National Research Council report on ...
ANDERSEN Melvin E. +20 more
core +1 more source
BAP1 in cancer: epigenetic stability and genome integrity
Discover Oncology, 2022 Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display hypersusceptibility to exposure-associated cancers, such as asbestos-driven ...
Sabrina Caporali +2 more
doaj +1 more source
Journal of Nanotheranostics, 2023 The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development.
Akash Kumar +2 more
doaj +1 more source
The Role of Alternative Testing Strategies in Environmental Risk Assessment of Engineered Nanomaterials [PDF]
, 2017 Within toxicology there is a pressure to find new test systems to replace, reduce and refine animal testing.
Colman, Ben +5 more
core +3 more sources
Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications
Journal of Nanotheranostics, 2023 A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures
Akash Kumar +2 more
doaj +1 more source
Systems biology tools for toxicology [PDF]
Archives of Toxicology, 2012 An important goal of toxicology is to understand and predict the adverse effects of drugs and other xenobiotics. For pharmaceuticals, such effects often emerge unexpectedly in man even when absent from trials in vitro and in animals. Although drugs and xenobiotics act on molecules, it is their perturbation of intracellular networks that matters.
Geenen S +5 more
openaire +5 more sources