Results 31 to 40 of about 320,373 (282)

Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Current Research in Toxicology, 2023
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not ...
Marie-Christin Jäger, Friedrich L. Joos, Denise V. Winter, Alex Odermatt   +3 more
doaj   +1 more source

Insect in vitro System for Toxicology Studies — Current and Future Perspectives

Frontiers in Toxicology, 2021
In vitro cell culture practices are valuable techniques to understand the mechanisms behind vital in vivo biological processes. In vitro cells have helped us to attain a deeper understanding of functions and mechanisms conserved in the course of ...
Sheeja Cc, Damodaran Arun, Lekha Divya
doaj   +1 more source

Harvesting the Promise of AOPs: An assessment and recommendations [PDF]

, 2018
The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals.
Ankley, Gerald T., Carusi, Annamaria, Davies, Mark R., De Grandis, Giovanni De, Escher, Beate I., Hodges, Geoff, Wheelan, Maurice, Willet, Catherine, Y. Leung, Kenneth M.   +8 more
core   +4 more sources

Multi-Behavioral Endpoint Testing Of An 87-Chemical Compound Library In Freshwater Planarians [PDF]

, 2018
There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models.
Collins, Eva-Maria S., Graham, A., Hagstrom, D., Hayes, P., Zhang, S.   +4 more
core   +3 more sources

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

Frontiers in Immunology
IntroductionCytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes.Results/MethodsBy combining
Alexander Mazein, Oxana Lopata, Kristin Reiche, Kristin Reiche, Kristin Reiche, Katherina Sewald, Katherina Sewald, Miriam Alb, Christina Sakellariou, Patricia Gogesch, Hannah Morgan, Vanessa Neuhaus, Vanessa Neuhaus, Nhu-Nguyen Pham, Nhu-Nguyen Pham, Charline Sommer, Charline Sommer, Ethan Perkins, Ethan Perkins, Birgit Fogal, Muhammad Shoaib, Reinhard Schneider, Reinhard Schneider, Venkata Satagopam, Venkata Satagopam, Marek Ostaszewski, Marek Ostaszewski   +26 more
doaj   +1 more source

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

Frontiers in Systems Biology
Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant in global aquatic ecosystems with increasing concern for its toxicity to aquatic wildlife through inadvertent exposures.
Rayna M. Nolen, Lene H. Petersen, Karl Kaiser, Karl Kaiser, Antonietta Quigg, Antonietta Quigg, Antonietta Quigg, David Hala   +7 more
doaj   +1 more source

Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs [PDF]

, 2019
© 2019. ElsevierOne of the major challenges that faces today regulatory risk assessment is to speed up the way of assessing threshold sublethal detrimental effects of existing and new chemical products.
Barata Martí, Carlos, Blasco Gutiérrez, Víctor, Martínez Jerónimo, Fernando, Moreno-Noguer, Francesc, Pestana, Joao, Porta Pleite, Josep Maria, Raldúa Pérez, Demetrio José, Simão, Fátima C.P., Soarez, Amadeu   +8 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source