Results 31 to 40 of about 108,508 (278)

Role of Tunable Gold Nanostructures in Cancer Nanotheranostics: Implications on Synthesis, Toxicity, Clinical Applications and Their Associated Opportunities and Challenges

Journal of Nanotheranostics, 2023
The existing diagnosis and treatment modalities have major limitations related to their precision and capability to understand several stages of disease development.
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications

Journal of Nanotheranostics, 2023
A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures
Akash Kumar, Nabojit Das, Raja Gopal Rayavarapu   +2 more
doaj   +1 more source

Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays

Current Research in Toxicology, 2023
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment, those metabolizing endogenous bioactive molecules are usually not ...
Marie-Christin Jäger, Friedrich L. Joos, Denise V. Winter, Alex Odermatt   +3 more
doaj   +1 more source

In silico biomarker analysis of the adverse effects of perfluorooctane sulfonate (PFOS) exposure on the metabolic physiology of embryo-larval zebrafish

Frontiers in Systems Biology
Perfluorooctane sulfonate (PFOS) is a ubiquitous pollutant in global aquatic ecosystems with increasing concern for its toxicity to aquatic wildlife through inadvertent exposures.
Rayna M. Nolen, Lene H. Petersen, Karl Kaiser, Karl Kaiser, Antonietta Quigg, Antonietta Quigg, Antonietta Quigg, David Hala   +7 more
doaj   +1 more source

Identification of environmental etiologies of neurodevelopmental disorders in children

生物医学转化
Neurodevelopmental disorders (NDDs) are a group of chronic developmental brain dysfunctions caused by various genetic or acquired factors, characterized by high disability rates and a lack of effective treatments.
Li Yuanyuan
doaj   +1 more source

Insect in vitro System for Toxicology Studies — Current and Future Perspectives

Frontiers in Toxicology, 2021
In vitro cell culture practices are valuable techniques to understand the mechanisms behind vital in vivo biological processes. In vitro cells have helped us to attain a deeper understanding of functions and mechanisms conserved in the course of ...
Sheeja Cc, Damodaran Arun, Lekha Divya
doaj   +1 more source

A Combined In Vitro/In Silico Approach to Identifying Off-Target Receptor Toxicity

iScience, 2018
Summary: Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in ...
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Áine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb   +9 more
doaj   +1 more source

Systems Toxicology of Male Reproductive Development- Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes: Data Associated with Publication

, 2018
Data associated with publication on Systems Toxicology of Male Reproductive Development- Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes.
EPA's National Center for Computational Toxicology (5039467)
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source