Results 51 to 60 of about 108,508 (278)

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Indoor air pollution and its association with poor lung function, microalbuminuria and variations in blood pressure among kitchen workers in India: a cross-sectional study

Environmental Health, 2017
Background The present study is an attempt to explore the association between kitchen indoor air pollutants and physiological profiles in kitchen workers with microalbuminuria (MAU) in north India (Lucknow) and south India (Coimbatore).
Amarnath Singh, Chandrasekharan Nair Kesavachandran, Ritul Kamal, Vipin Bihari, Afzal Ansari, Parappurath Abdul Azeez, Prem Narain Saxena, Anil Kumar KS, Altaf Hussain Khan   +8 more
doaj   +1 more source

Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats

Frontiers in Medicine, 2023
Arsenic (As) exposure is progressively associated with chronic kidney disease (CKD), a leading public health concern present worldwide. The adverse effect of As exposure on the kidneys of people living in As endemic areas have not been extensively ...
Radha Dutt Singh, Radha Dutt Singh, Ratnakar Tiwari, Vineeta Sharma, Vineeta Sharma, Hafizurrahman Khan, Hafizurrahman Khan, Siddhartha Gangopadhyay, Siddhartha Gangopadhyay, Sukhveer Singh, Sukhveer Singh, Kavita Koshta, Kavita Koshta, Shagun Shukla, Nidhi Arjaria, Kapil Mandrah, Kapil Mandrah, Pankaj Ramji Jagdale, Satyakam Patnaik, Satyakam Patnaik, Somendu Kumar Roy, Somendu Kumar Roy, Dhirendra Singh, Ashok Kumar Giri, Vikas Srivastava, Vikas Srivastava   +25 more
doaj   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture after Exposure to Cigarette Smoke in Vitro

Bioinformatics and Biology Insights, 2015
To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed human organotypic bronchial epithelial tissue cultures at the air liquid interface (ALI) to ...
Carole Mathis, Stephan Gebel, Carine Poussin, Vincenzo Belcastro, Alain Sewer, Dirk Weisensee, Arnd Hengstermann, Sam Ansari, Sandra Wagner, Manuel C. Peitsch, Julia Hoeng   +10 more
doaj   +1 more source

Functional toxicology: tools to advance the future of toxicity testing

Frontiers in Genetics, 2014
The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often ...
Brandon David Gaytán, Chris eVulpe
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

From drug identification to systems toxicology

, 2017
Biomedical sciences are at the edge of an extraordinary transformation in the conduct of toxicological evaluations using modern biomolecular analysis techniques to elucidate mechanisms of toxicity.
Favretto D., Donata Favretto
core   +1 more source

Stem Cell-Derived Systems in Toxicology Assessment [PDF]

, 2015
Industrial sectors perform toxicological assessments of their potential products to ensure human safety and to fulfill regulatory requirements. These assessments often involve animal testing, but ethical, cost, and time concerns, together with a ban on ...
Flick, B., Mistry, Pratibha, Jennings, P., Water, B. van de, LS IRAS Tox CMT/ATX, Brito, C., Stedman, D., Hescheler, J., Risk Assessment of Toxic and Immunomodulatory Agents, Coecke, S., Blaauboer, Bas J., Hescheler, Juergen, Bremm, K.-D., Kelm, J.M., Blaauboer, B.J., Alves, P.M., IRAS RATIA1, Suter-Dick, Laura, Ingelman-Sundberg, M., Fowler, Paul, Manou, I., Flick, Burkhard, Mistry, P., Beilmann, Mario, Roth, A., Bremm, Klaus-Dieter, Stedman, Donald, Moretto, Angelo, Roth, Adrian, Brito, Catarina, Beilmann, M., Coecke, Sandra, Suter-Dick, L., Ingelman-Sundberg, Magnus, Kelm, Jens M., Jennings, Paul, Hescheler, Jürgen, Moretto, A., Manou, Irene, Alves, Paula M., van de Water, Bob, Fowler, P.   +41 more
core   +1 more source