Results 41 to 50 of about 320,373 (282)

Identification of environmental etiologies of neurodevelopmental disorders in children

生物医学转化
Neurodevelopmental disorders (NDDs) are a group of chronic developmental brain dysfunctions caused by various genetic or acquired factors, characterized by high disability rates and a lack of effective treatments.
Li Yuanyuan
doaj   +1 more source

The European Registered Toxicologist (ERT) : Current status and prospects for advancement [PDF]

, 2016
Acknowledgements We would like to thank the participants of the five workshops in which the issues presented in this paper were discussed and the revised guidelines prepared, as well as the EUROTOX Executive Committee and the societies of toxicology of ...
Basaran, Nursen, Blaauboer, Bas J., Bonefeld-Jørgensen, Eva Cecilie, Bourrinet, Philippe, Brueller, Werner, Claude, Nancy, Galli, Corrado L., Grönlund, Marie Haag, Gundert-Remy, Ursula, Håkansson, Helen, Johanna Zilliacus, Johanna, Kovatsi, Leda, Leconte, Isabelle, Liesivuori, Jyrki, Lindeman, Brigitte, Lison, Dominique, Lopez, Emma Martinez, Matovic, Vesna, Michel, Cecile, Miranda, Joana P., Murias, Marek, Scheepers, Paul T.J., Schulte-Hermann, Rolf, Stanley, Lesley, Teixeira, Joao Paulo, Tsatsakis, Aristidis, Wallace, Heather M., Wilks, Martin F.   +27 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Receptor‐Free Identification of Toxic Gases Enabled by Hygroscopic Aqueous Salt Films

Advanced Functional Materials, EarlyView.
Water as a gas sensor coating sounds impossible—until it stops evaporating. Here, hygroscopic salt solutions (LiCl, LiBr, H3PO4) form non‐drying aqueous films on CNT chemiresistors under ambient air. Gases partition into these liquid layers, sometimes transforming into water, and generate salt‐specific resistance fingerprints across a four‐channel ...
Seongwoo Lee, Yun‐Tae Kim, Hwarang Choi, Sanghwan Park, Seongyeop Lim, Chang Young Lee   +5 more
wiley   +1 more source

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats

Frontiers in Medicine, 2023
Arsenic (As) exposure is progressively associated with chronic kidney disease (CKD), a leading public health concern present worldwide. The adverse effect of As exposure on the kidneys of people living in As endemic areas have not been extensively ...
Radha Dutt Singh, Radha Dutt Singh, Ratnakar Tiwari, Vineeta Sharma, Vineeta Sharma, Hafizurrahman Khan, Hafizurrahman Khan, Siddhartha Gangopadhyay, Siddhartha Gangopadhyay, Sukhveer Singh, Sukhveer Singh, Kavita Koshta, Kavita Koshta, Shagun Shukla, Nidhi Arjaria, Kapil Mandrah, Kapil Mandrah, Pankaj Ramji Jagdale, Satyakam Patnaik, Satyakam Patnaik, Somendu Kumar Roy, Somendu Kumar Roy, Dhirendra Singh, Ashok Kumar Giri, Vikas Srivastava, Vikas Srivastava   +25 more
doaj   +1 more source

Post-mortem toxicology: A pilot study to evaluate the use of a Bayesian network to assess the likelihood of fatality [PDF]

, 2015
The challenge of interpreting post-mortem drug concentrations is well documented and relies on appropriate sample collection, knowledge of case circumstances as well as reference to published tables of data, whilst taking into account the known issues of
Bolton, Jennifer, Carlin, Michelle, Langford, Alan, Palmer, Ray   +3 more
core   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

In silico predictions of drug-induced changes in human cardiac contractility align with experimental recordings

Frontiers in Pharmacology
Drug-induced changes in cardiac contractility (inotropy) can lead to cardiotoxicity, a major cause of discontinuation in drug development. Preclinical approaches to assess cardiac inotropy are imperfect, with in vitro assays limited to stem cell-derived ...
Cristian Trovato, Cristian Trovato, Stefano Longobardi, Elisa Passini, Kylie A. Beattie, Maxx Holmes, Khuram W. Chaudhary, Eric I. Rossman, Blanca Rodriguez   +8 more
doaj   +1 more source