Results 41 to 50 of about 108,508 (278)

Translational toxicology in zebrafish [PDF]

, 2020
A major goal of translational toxicology is to identify adverse chemical effects and determine whether they are conserved or divergent across experimental systems.
Yaghoobi, Bianca, Tal, Tamara, Lein, Pamela J   +2 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies

Frontiers in Immunology
IntroductionCytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes.Results/MethodsBy combining
Alexander Mazein, Oxana Lopata, Kristin Reiche, Kristin Reiche, Kristin Reiche, Katherina Sewald, Katherina Sewald, Miriam Alb, Christina Sakellariou, Patricia Gogesch, Hannah Morgan, Vanessa Neuhaus, Vanessa Neuhaus, Nhu-Nguyen Pham, Nhu-Nguyen Pham, Charline Sommer, Charline Sommer, Ethan Perkins, Ethan Perkins, Birgit Fogal, Muhammad Shoaib, Reinhard Schneider, Reinhard Schneider, Venkata Satagopam, Venkata Satagopam, Marek Ostaszewski, Marek Ostaszewski   +26 more
doaj   +1 more source

Toxicology of the respiratory system

Folia Pharmacologica Japonica, 2009
呼吸器は，空気から酸素を取り入れ血液から二酸化炭素を放出するガス交換を行うための器官である．空気中に存在す化学物質は呼吸を通して体内に入るため，呼吸器はこれらの化学物質に最初に接触しその影響を最も受けやすい器官である．このため，大気汚染物質による健康障害では呼吸器が標的器官となることが多い．医薬品の分野では，吸入以外の経路でも抗癌剤等による薬剤性肺障害の報告があり，本誌でも詳しい総説がある（1）．また，近年は経鼻投与など経気道的に投与する薬剤の実用化が進んでおり，医薬品の開発に際して鼻腔などの気道を含む呼吸器への直接的な接触による副作用が課題になってきている．本稿では，鼻腔等の気道を中心として，呼吸器の構造と機能，呼吸器毒性の検査法，薬剤等による呼吸器毒性について概説する．
openaire   +3 more sources

Comprehensive summary--Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing

, 2015
This special issue of Toxicology in Vitro is dedicated to disseminating the results of the EU-funded collaborative project "Profiling the toxicity of new drugs: a non animal-based approach integrating toxicodynamics and biokinetics" (Predict-IV; Grant ...
Mueller, Stefan O, Testai, Emanuela, Bois, Frederic Y, Mueller, Stefan O., Dekant, Wolfgang, Bois, Frédéric Y., Jennings, Paul, Bois, Frederic, Jennings, Paul; id_orcid, Dekant, Wolfang, Müller, Stefan O.   +10 more
core   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, EarlyView.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source

Receptor‐Free Identification of Toxic Gases Enabled by Hygroscopic Aqueous Salt Films

Advanced Functional Materials, EarlyView.
Water as a gas sensor coating sounds impossible—until it stops evaporating. Here, hygroscopic salt solutions (LiCl, LiBr, H3PO4) form non‐drying aqueous films on CNT chemiresistors under ambient air. Gases partition into these liquid layers, sometimes transforming into water, and generate salt‐specific resistance fingerprints across a four‐channel ...
Seongwoo Lee, Yun‐Tae Kim, Hwarang Choi, Sanghwan Park, Seongyeop Lim, Chang Young Lee   +5 more
wiley   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

In silico predictions of drug-induced changes in human cardiac contractility align with experimental recordings

Frontiers in Pharmacology
Drug-induced changes in cardiac contractility (inotropy) can lead to cardiotoxicity, a major cause of discontinuation in drug development. Preclinical approaches to assess cardiac inotropy are imperfect, with in vitro assays limited to stem cell-derived ...
Cristian Trovato, Cristian Trovato, Stefano Longobardi, Elisa Passini, Kylie A. Beattie, Maxx Holmes, Khuram W. Chaudhary, Eric I. Rossman, Blanca Rodriguez   +8 more
doaj   +1 more source