Results 61 to 70 of about 320,373 (282)
3S - Systematic, systemic, and systems biology and toxicology
ALTEX, 2018 A biological system is more than the sum of its parts - it accomplishes many functions via synergy. Deconstructing the system down to the molecular mechanism level necessitates the complement of reconstructing functions on all levels, i.e., in our conceptualization of biology and its perturbations, our experimental models and computer modelling ...
Smirnova, Lena +5 more
openaire +4 more sources
A Distributed Solution to the PTE Problem [PDF]
, 1999 Proceeding of: AAAI Spring Symposium on Predictive Toxicology, AAAI Press, Stanford, March 1999A wide panoply of machine learning methods is available for application to the Predictive Toxicology Evaluation (PTE) problem.
Borrajo Millán, Daniel +2 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.A human microfluidic blood‐brain barrier (mBBB) model enables spatially resolved comparison of nanoparticle trafficking. Extracellular vesicles (EVs), liposomes, and nanoplastics exhibit distinct transport and disruption behaviors, revealing that membrane composition and uptake pathways govern BBB interaction.
Bryan B. Nguyen +9 more
wiley +1 more source
Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products
Toxicology Reports, 2019 The adverse effects of cigarette smoking are well documented, and the two main strategies for reducing smoking prevalence are prevention of smoking initiation and promotion of smoking cessation.
Marco van der Toorn +6 more
doaj +1 more source
Advanced Materials, EarlyView.A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee +8 more
wiley +1 more source
The systems toxicology challenge
Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics, 2015 Risk assessment in the context of 21st century toxicology relies on the elucidation and understanding of mechanisms of toxicity. For that purpose, datasets generated by high-throughput technologies (e.g., high-throughput/content screening) combined with various omics data types are now generated in vitro to test large and diverse set of chemicals (e.g.
Poussin, Carine +8 more
openaire +2 more sources
A Network Toxicology Approach for Mechanistic Modelling of Nanomaterial Hazard and Adverse Outcomes
Advanced ScienceHazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity.
Giusy del Giudice +9 more
doaj +1 more source
Antidote application: an educational system for treatment of common toxin overdose [PDF]
, 2017 Poisonings account for almost 1% of emergency room visits each year. Time is a critical factor in dealing with a toxicologic emergency. Delay in dispensing the first antidote dose can lead to life-threatening sequelae.
Brusic, V. +4 more
core
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
Applied and Environmental MicrobiologyMicrobial arsenic (As) volatilization plays a significant role in the global As biogeochemical cycle and presents a promising approach for bioremediation. In this study, an autotrophic strain of Stenotrophomonas maltophilia was isolated from sewage water
Diksha Singh +9 more
doaj +1 more source