Results 81 to 90 of about 108,508 (278)

Targeting TDP-43 Proteinopathy in hiPSC-Derived Mutated hNPCs with Mitoxantrone Drugs and miRNAs

Pharmaceutics
Background/Objectives: TDP-43 mutation-driven Amyotrophic Lateral Sclerosis (ALS) motor neuron disease is one of the most prominent forms (approximately 97%) in cases of sporadic ALS.
Uzair A. Ansari, Ankita Srivastava, Ankur K. Srivastava, Abhishek Pandeya, Pankhi Vatsa, Renu Negi, Akash Singh, Aditya B. Pant   +7 more
doaj   +1 more source

Systems biology and synthetic biology: A new epoch for toxicology research [PDF]

, 2015
Copyright © 2015 Mark T. Mc Auley et al. This is an open access article distributed under the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Hyunok Choi, Miller, Veronica M., Hyunok, Choi, Mark T. Mc Auley, Kathleen Mooney, Paul, Emily, Mooney, Kathleen M., Veronica M. Miller, Choi, Hyunok, Emily Paul, Mc Auley, Mark T, Mooney, Kathleen, Mc Auley, Mark T.   +12 more
core   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

Toxicity of Dietary Exposure to 3-Monochloropropanediol, Glycidol, and Their Fatty Acid Esters

Journal of Food Quality
3-Monochloropropane-1,2-diol (3-MCPD), 2,3-epoxy-1-propanol (glycidol), and their fatty acid esters are heat-induced food toxicants that have widely been investigated. This review study presents an overview of current knowledge about the dietary toxicity
Daniel Sitsofe Yabani, Isaac Williams Ofosu, Gloria Mathanda Ankar-Brewoo, Herman Erick Lutterodt   +3 more
doaj   +1 more source

Systems Biology in Toxicology and Environmental Health From the Genome to the Epigenome

, 2015
Systems Biology in Environmental Health: From the Genome to the Epigenome brings a systems biological perspective to recent findings that link environmental exposures to human disease.
Fry, Rebecca
core  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

In silico toxicology – non-testing methods

Frontiers in Pharmacology, 2011
In silico toxicology in its broadest sense means anything that we can do with a computer in toxicology. Many different types of in silico methods have been developed to characterise and predict toxic outcomes in humans and environment.
Hannu eRaunio
doaj   +1 more source

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism

, 2015
One aim of systems toxicology is to deliver mechanistic, mathematically rigorous, models integrating biochemical and pharmacological processes that result in toxicity to enhance the assessment of the risk posed to humans by drugs and other xenobiotics ...
Wilson, Ian D., Nicholls, Andrew W., Yates, James W., Nicholson, Jeremy K., Kenna, JG, Coen, M, Yates, JW, Coen, Muireann, Ortega, F, Ortega, Fernando, Kenna, J. Gerry, Nicholls, AW, Wilson, ID, Stahl, Simone H., Stahl, SH, Nicholson, JK   +15 more
core   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Lipidome atlas of p53 mutant variants in pancreatic cancer

Biology Direct
Mutations in the tumour suppressor protein p53 are present in 70% of human pancreatic ductal adenocarcinomas (PDAC), subsequently to highly common activation mutation of the oncogene KRAS. These p53 mutations generate stable expression of mutant proteins,
Kian Cotton, Charley Comer, Sabrina Caporali, Alessio Butera, Stephanie Gurres, Francesco Capradossi, Angelo D’Alessandro, Ivano Amelio, Maria Victoria Niklison-Chirou   +8 more
doaj   +1 more source