Results 101 to 110 of about 102,232 (247)

NIR‐II Light‐Triggered Electron Flow Initiates Cuproptosis‐Centered Thermoelectric‐Immunotherapy for Breast Cancer

Advanced Science, EarlyView.
A NIR‐II light‐activatable thermoelectric nanoreactor converts surface‐bound Cu2+ into bioactive Cu+ via directed electron flow. This spatiotemporally controlled reduction triggers potent cuproptosis and immunogenic cell death, eradicating primary tumors and, together with aPD‐1 therapy, suppressing metastases while establishing durable immune memory ...
Boyu Yuan, Qin Fan, Shushu Chu, Shining Yang, Yuechao Yang, Chenxi Zhang, Jinqiao Zhang, Xinran Qu, Yiju Wei, Xin Wang, Ziliang Dong   +10 more
wiley   +1 more source

Current Collector Engineering for New Efficient Bioresorbable Sodium‐Ion Batteries

Advanced Science, EarlyView.
A bioresorbable Na‐ion battery is proposed with Mo or Mg thin‐film current collectors for temporary implants. Mo‐based batteries exhibit superior electrochemical performance and stable cycling compared with Mg counterparts. XPS was used to investigate the Mo/Mg surface oxidation.
Bincy Lathakumary Vijayan, Eleonora Vandini, Vedi Kuyil Azhagan Muniraj, Hussien Hammoud, Oussama Jamai, Eve Djenizian, Marc Ramuz, Daniela Giuliani, Manuela Zavatti, Yann Tison, Hervé Martinez, Lucas Teolis, Esma Ismailova, David Moreau, Sébastien Maria, Thierry Djenizian   +15 more
wiley   +1 more source

An Immediate‐Response Detection System for γ‐Hydroxybutyrate to Enhance Personal Safety in Social Environments

Advanced Science, EarlyView.
A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An, Jisung Kwak, Kyung Ho Kim, Chaeeun Kim, Sung Eun Seo, Nathaniel S. Hwang, Yong‐Sang Ryu, Hyun Seok Song, Oh Seok Kwon   +8 more
wiley   +1 more source

A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner

Cell & Bioscience
Background Hexose-6-phosphate dehydrogenase (H6PD) catalyzes the first two steps of the pentose-phosphate-pathway (PPP) within the endoplasmic reticulum, generating NADPH.
Gabriele Sakalauskaite, Michael Weingartner, Sophie Ebert, Gina Boot, Thomas Bock, Julia Birk, Maria Tsachaki, John W. Gallon, Salvatore Piscuoglio, Alex Odermatt   +9 more
doaj   +1 more source

From prediction to adaptation: rethinking the epistemic role of inhalation toxicology

Frontiers in Toxicology
Inhalation toxicology has long aimed to predict the health effects of airborne substances before exposure occurs, relying on stable dose-response relationships and well-characterized hazards.
Samir Dekali
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

HEAVY METAL-INDUCED NEUROTOXICITY AND IT'S AMELIORATION: ROLE OF GLIAL CELLS

IBRO Neuroscience Reports, 2023
Sanghamitra Bandyopadhyay, Neetu Shukla
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Quantitative systems toxicology

Nature Reviews Drug Discovery
Reliable prediction and prevention of adverse drug reactions (ADRs) remains a key challenge in the development of new medicines. Advanced mathematical and computational modelling approaches, which incorporate cutting-edge mechanistic understanding of ADRs in concert with systematically collected data addressing knowledge gaps, are integral components ...
Goldring, Christopher E., Russomanno, Giusy, Pin, Carmen, Trairatphisan, Panuwat, Beattie, Kylie A., Fisher, Ciaran P., Pinero, Janet, Brennan, Richard J., Clausznitzer, Diana, Copple, Ian M., de Kok, Theo M., Duckworth, Carrie A., Furlong, Laura I., Fuzi, Barbara, Gabor, Attila, Gall, Louis, Hengstler, Jan, Hermjakob, Henning, Hunter, Fiona, Jennen, Danyel, Koskinen, Mikko, Kunnen, Steven J., Lammens, Lieve, Lobentanzer, Sebastian, Mohr, Marcel, Passini, Elisa, Pritchard, D. Mark, Malik-Sheriff, Rahuman S., Rodriguez, Blanca, Rossman, Eric I., Saez-Rodriguez, Julio, Schmidt, Friedemann, Sison-Young, Rowena, Soininen, Inari, Turner, Sean, van de Water, Bob, van Hasselt, Johan G. C., Venezia, Filippo, Willy, Jeffrey A., Leishman, Derek J., Stevens, James L., Laplanche, Loic   +41 more
openaire   +2 more sources

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

Beilstein Journal of Nanotechnology
Heavy metal ions and organic pollutants, such as 4-nitrophenol (4-NP), pose significant environmental and human health threats. Addressing these challenges necessitates using advanced nanoparticle-based systems capable of efficient detection and ...
Akash Kumar, Raja Gopal Rayavarapu
doaj   +1 more source