Results 111 to 120 of about 108,508 (278)

Genetic toxicology

, 2007
The primary purposes of genetic toxicology are estimation of mutation appearance risk in both somatic and generative cells under different agents' action and decrease of negative consequences for a particular individual and whole population.
Ludmila V Bondarenko
core   +1 more source

A Wireless 3D Magneto‐Mechanical Stimulation Platform Drives In Situ Chondrogenic Commitment of Endogenous MSCs

Advanced Science, EarlyView.
An intracellular magneto‐mechanical platform utilizing MSC‐targeted nanomotors is developed. After intra‐articular delivery, these nanomotors target endogenous BMSCs and are actuated within lysosomes to execute trans‐planar rotational‐bouncing motions under a rotating‐fluctuating 3D magnetic field, generating amplified mechanical stimulation.
Zhenguang Li, Li Peng, Laiya Lu, Yingying Wang, Xiaolei Chen, Feng Yin, Cuijun Deng, Yu Cheng   +7 more
wiley   +1 more source

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury. [PDF]

Int J Mol Sci, 2023
Beaudoin JJ, Clemens L, Miedel MT, Gough A, Zaidi F, Ramamoorthy P, Wong KE, Sarangarajan R, Battista C, Shoda LKM, Siler SQ, Taylor DL, Howell BA, Vernetti LA, Yang K.   +14 more
europepmc   +1 more source

Systems Toxicology 2016: computational models of cardiac electrophysiology for pro-arrhythmic safety testing

, 2016
A presentation given by Gary Mirams at Systems Toxicology 2016, Les Diablerets, Switzerland on 28th Jan 2016.
Gary Mirams (398325)
core   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Artificial Intelligence Applications in Emergency Toxicology: Advancements and Challenges

Journal of Medical Internet Research
Emergency toxicology is a complex field requiring rapid and precise decision-making to manage acute poisonings effectively. Toxic exposures are often unpredictable, and the constraints of time and resources often challenge conventional diagnostic and ...
Lorraine Pei Xian Yong, Joshua Yi Min Tung, Nicole Mun Teng Cheung, Zi Yao Lee, Ee Yang Ng, Alexander Jet Yue Ng, Clement Kee Woon Lim, Yuru Boon, Daniel Yan Zheng Lim, Gerald Gui Ren Sng, Jonathan Zhe Ying Tang   +10 more
doaj   +1 more source

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling. [PDF]

Toxicol Sci, 2022
Woodhead JL, Siler SQ, Howell BA, Watkins PB, Conway C.   +4 more
europepmc   +1 more source

Handbook on the toxicology of metals.

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field.
Fowler, Bruce A.,editor., Nordberg, Monica,editor., Nordberg, Gunnar,editor.   +2 more
core  

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Building medical toxicology capacity in Africa: a review and strategic perspective on the need for fellowship training programs

International Journal of Emergency Medicine
Introduction Toxic exposures and poisoning constitute a substantial but underestimated public health hazard throughout Africa, for which pesticides, drugs, traditional medicine, snake venom, and industrial chemicals are a disproportionate cause of ...
Belayneh Dessie Kassa
doaj   +1 more source