Results 121 to 130 of about 108,508 (278)

Forensic toxicology ::mechanisms and pathology /

, 2022
Designed for upper-level undergraduate and graduate-level courses, Forensic Toxicology: Mechanisms and Pathology introduces toxicology concepts from a forensic perspective.
Dean, Dorothy E.,, Powers, Robert H.,
core  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Medulloblastoma response to mevalonate pathway inhibition is independent of p53 status

Biology Direct
Medulloblastoma (MB) is the most common primary solid paediatric brain tumour. It arises in the cerebellum, the part of the brain responsible for equilibrium and coordination.
Charley Comer, Christopher Edwards, Sabrina Caporali, Yuhui Lu, Alessio Butera, David Michod, Andreas J. Gruber, Ivano Amelio, Maria Victoria Niklison-Chirou   +8 more
doaj   +1 more source

Computational chemistry, systems biology and toxicology. Harnessing the chemistry of life: Revolutionizing toxicology. A commentary

, 2011
There is a continuing interest in, and increasing imperatives for, the development of alternative methods for toxicological evaluations that do not require the use of animals.
Humphris, Colin, Ian Kimber, Irene Manou, Alepee, Nathalie, Nathalie Alepee, Gianni Dal Negro, Westmoreland, Carl, Negro, Gianni Dal, Kimber, Ian, Manou, Irene, Carl Westmoreland, Colin Humphris   +11 more
core   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Quantitative Systems Toxicology Modeling Predicts that Reduced Biliary Efflux Contributes to Tolvaptan Hepatotoxicity. [PDF]

Clin Pharmacol Ther, 2021
Beaudoin JJ, Brock WJ, Watkins PB, Brouwer KLR.   +3 more
europepmc   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Liposome-water and octanol-water partitioning of alcohol ethoxylates

, 1999
Haitzer M, Burnison BK, Hoess S, Traunspurger W, Steinberg C. Effects of quantity, quality, and contact time of dissolved organic matter on bioconcentration of benzo[a]pyrene in the nematode, Caenorhabditis elegans. Environmental Chemistry and Toxicology.
Preston, S., Escher, BI, Plans, M., Clarke, KR, Steinberg, CEW, Scheper, B.B., Leonards, P.E.G., Cofino, W.P., Traunspurger, Walter, Stronkhorst, J., Hoss, S, Burnison, B.K., Prow, Tarl, Tronczynski, J., Sanderson, T., Pignatello, Joseph J., Vermeulen, N.P.E., Knight, B., McGrath, S. P., Ratte, Hans Toni, de Haas, E., Wim P. Cofino, Thomas, Kevin V., Muller, MT, Chasteen, Thomas G., Paton, G. I., Brinkman, U.A.T., Bleeker, E.A.J., Patel, Shiv J., Steinberg, C., Albanis, T.A., Boyd, Elaine M., Chambers, Susan M., Killham, K., Thompson, Ian P., Watson, John, Meharg, Andrew A.; id_orcid, Admiraal, W., Haitzer, M., Greve, G.D., Stuijfzand, S.C., Alexander, Martin, Commandeur, J.N.M., Cairney, John W G, Vooijs, R., Thain, John E., Damia Barceló, White, Jason C., Fisher, Nicholas S., van Hattum, A.G.M., Van Fleet-Stalder, Verena, Udo A. Th. Brinkman, Leslie, H.A., Schat, H., Sharma, S.S., Liles, Nathan, Groenendijk, D., Pim E. G. Leonards, Vermeulen, N.P.E.; id_orcid, Dickerson, Sarah, Maguire, Nicola, Barceló, D., Bowmer, C.T., Sailer, Brian L., Zehnder, AJB, Hans Toni Ratte, Haitzer, M, Sharples, Jade M., Kraak, M.H.S., Vooijs, H., Wang, Wen Xiong, Jacek Tronczynski, Augustijn, C., Bailey, Mark J., Waldock, Michael J., Ruud J. C. A. Steen, van Wezel, A., Hoess, S., Steen, R.J.C.A., Hunter, Margaret, Triantafyllos A. Albanis, Ellis, Richard J., Leonards, P.E.G.; id_orcid, van der Geest, H.G., Nam, Kyoungphile, van Heerwaarden, L.M.   +85 more
core   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source