Results 141 to 150 of about 320,373 (282)

A BioID-based approach uncovers the interactome of hexose-6-phosphate dehydrogenase in breast cancer cells and identifies anterior gradient protein 2 as an interacting partner

Cell & Bioscience
Background Hexose-6-phosphate dehydrogenase (H6PD) catalyzes the first two steps of the pentose-phosphate-pathway (PPP) within the endoplasmic reticulum, generating NADPH.
Gabriele Sakalauskaite, Michael Weingartner, Sophie Ebert, Gina Boot, Thomas Bock, Julia Birk, Maria Tsachaki, John W. Gallon, Salvatore Piscuoglio, Alex Odermatt   +9 more
doaj   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

HEAVY METAL-INDUCED NEUROTOXICITY AND IT'S AMELIORATION: ROLE OF GLIAL CELLS

IBRO Neuroscience Reports, 2023
Sanghamitra Bandyopadhyay, Neetu Shukla
doaj   +1 more source

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

Beilstein Journal of Nanotechnology
Heavy metal ions and organic pollutants, such as 4-nitrophenol (4-NP), pose significant environmental and human health threats. Addressing these challenges necessitates using advanced nanoparticle-based systems capable of efficient detection and ...
Akash Kumar, Raja Gopal Rayavarapu
doaj   +1 more source

Environmental Toxicology: The legacy of Silent Spring [PDF]

, 2004
The transcript of a Witness Seminar held by the Wellcome Trust Centre for the History of Medicine at UCL, London, London, on 12 March 2002. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2004.©The Trustee of the Wellcome
Christie, DA, Tansey, EM
core  

Species Dependent Toxicity Comparison Outcome

Advanced Science, EarlyView.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source

Sunset Yellow protects against oxidative damage and exhibits chemoprevention in chemically induced skin cancer model

npj Systems Biology and Applications
Skin cancer and other skin-related inflammatory pathologies are rising due to heightened exposure to environmental pollutants and carcinogens. In this context, natural products and repurposed compounds hold promise as novel therapeutic and preventive ...
Saurabh Singh, Sarika Yadav, Celine Cavallo, Durgesh Mourya, Ishu Singh, Vijay Kumar, Sachin Shukla, Pallavi Shukla, Romil Chaudhary, Gyan Prakash Maurya, Ronja Lea Jennifer Müller, Lilly Rohde, Aradhana Mishra, Olaf Wolkenhauer, Shailendra Gupta, Anurag Tripathi   +15 more
doaj   +1 more source

Deoxyribonucleic acid damage in Iranian veterans 25 years after wartime exposure to sulfur mustard [PDF]

, 2013
• Background: More than 100,000 Iranian veterans and civilians still suffer from various long-term complications due to their exposure to sulfur mustard (SM) during the Iran–Iraq war in 1983–88. The aim of the study was to investigate DNA damage of SM in
Balali-Mood, Mahdi, Behravan, Effat, Blain, Peter G., Jowsey, Paul, Khateri, Shahriar, Maraghi, Elham, Moallem, Seyed Adel   +6 more
core   +3 more sources

Tracking of [14C]Polystyrene Nanoplastics in Pregnant Mice

Advanced Science, EarlyView.
This study investigates [14C]polystyrene nanoplastic ([14C]PS) translocation in late‐stage pregnant mice after intranasal (0.5 mg of [14C]PS on GD12, GD14, and GD16, n = 6) and intravenous administration (1.5 mg of [14C]PS on GD16, n = 6). 14C‐radiolabel allows quantitative tracking of unmodified polystyrene nanoplastics.
Olga Khaybullina, Pallavi Sarkhel, Outi M. Keinänen   +2 more
wiley   +1 more source

Single‐Particle Mid‐Infrared Photothermal Imaging Reveals Hidden Heterogeneity in Real‐World Micro‐ and Nanoplastics

Advanced Science, EarlyView.
Mid‐infrared photothermal imaging enables multidimensional profiling of micro‐ and nanoplastics in bottled water. A total of 9.9 × 104 particles L−1 is detected, with 64% in the nanoscale regime. Spectral evolution, including peak narrowing and band shifts, reveals local chain reorganization in polyethylene terephthalate (PET), highlighting intrinsic ...
Xinyu Deng, Yongqing Zhang, Xiaobin Tang, Hyeon Jeong Lee, Delong Zhang   +4 more
wiley   +1 more source