Results 131 to 140 of about 49,900 (290)

Cumulative heatwave stress disrupts thermal homeostasis and plumage structure in a Mediterranean passerine

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Heatwaves are becoming increasingly frequent across the Mediterranean and pose critical challenges for small passerines, yet the physiological and morphological limits to their resilience remain poorly understood.
Erick González‐Medina, Núria Playà‐Montmany, Julián Cabello‐Vergel, Marta Precioso, Deseada Parejo, Auxiliadora Villegas, José A. Masero   +6 more
wiley   +1 more source

Early Epidemiologic and Immune Predictors of Atopic Dermatitis: Reduced Cord Blood Regulatory B10 Cells in the Munich Atopy Prediction Study (MAPS)

Allergy, EarlyView.
In this prospective birth cohort from Munich, comprehensive clinical assessments and longitudinal lifestyle questionnaires were combined with cord blood immune profiling. Infants who later developed AD showed altered cord blood immune signatures, including reduced CD4+ T cells, increased B cells and markedly decreased Breg cells. Epidemiologic factors,
S. Preis, S. Kaesler, M. Koeberle, M. Hils, B. Evers, R. L. Silva, Y. Skabytska, L. Schellenberger, H. Hufnagel, M. Schielein, B. Kuschel, Y. Amar, A. Zink, T. Biedermann, Z. Kurgyis   +14 more
wiley   +1 more source

Electric field control of magnetic properties of Nd2Fe14B thin films grown onto PMN-PT substrates

, 2017
Nd2Fe14B films with easy magnetization axis perpendicular to the film plane were grown onto Ta-buffered piezoelectric (011)-0.7Pb(Mg1/3Nb2/3)O-3-0.3PbTiO(3) (PMN-PT) substrates using a magnetron sputtering technique.
Yao Liu, Zhang, Jian, Feng-xia Hu, Shen, Fei-ran, Shen, Bao-gen, Ming Zhang, Bao-gen Shen, Jing Wang, Wang, Jing, Liu, Yao, Jian Zhang, Fei-ran Shen, Wen-liang Zuo, Zuo, Wen-liang, Hu, Feng-xia, Sun, Ji-rong, Ji-rong Sun, Zhang, Ming   +17 more
core   +1 more source

PKN2 enhances the immunosuppressive activity of polymorphonuclear myeloid-derived suppressor cells in esophageal carcinoma by mediating fatty acid oxidation

Molecular Medicine
Background Myeloid-derived suppressor cells (MDSCs) in tumor microenvironment reduce the efficacy of immunotherapy. PKN2 plays a role in colon cancer, but its function in esophageal cancer (EC) remains unclear.
Xiao Fu, GuoQing Zhang, ZhiChao Hou, TingTing Fu, GuangHui Cui   +4 more
doaj   +1 more source

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

A Nationwide Assessment of Anticholestatic Therapy Uptake in Patients With Primary Biliary Cholangitis: Opportunities for Optimisation

Alimentary Pharmacology &Therapeutics, EarlyView.
Among a nationwide population with primary biliary cholangitis, almost all people were prescribed ursodeoxycholic acid (UDCA). However, UDCA was insufficiently dosed in a one third of them. The results indicate that first‐line treatment can be optimized, particularly in those with a biochemical response and higher body weight.
Ellen Werner, Maria C. B. van Hooff, Gemma H. X. Weijsters, Maria A. van de Vrie, Rozanne C. de Veer, Ulrich Beuers, Joost P. H. Drenth, Frans J. C. Cuperus, Remco van Dijk, Bart J. Veldt, Michael Klemt‐Kropp, Suzanne van Meer, Robert C. Verdonk, Hajo J. Flink, Jan Maarten Vrolijk, Matthijs Kramer, Cyriel Y. Ponsioen, Kirsten Boonstra, Femke Boersma, Hendrik J. M. de Jonge, Frank H. J. Wolfhagen, L. C. Baak, Susanne L. Onderwater, Jeroen D. van Bergeijk, Paul G. van Putten, Gijs J. de Bruin, Rob P. R. Adang, Maria N. Aparicio‐Pages, Wink de Boer, Frank ter Borg, Hanneke van Soest, Elsemieke S. de Vries, Nicole S. Erler, Bettina E. Hansen, Harry L. A. Janssen, Adriaan J. van der Meer, on behalf of the Dutch PBC Study Group, Adriaan J. van der Meer, Anne Vrieze, A. (Sander) van der Beek, Bart J. Veldt, Bart van Hoek, Bettina E. Hansen, Cyriel Y. Ponsioen, Daphne M. Hotho, Djuna L. Cahen, Edith M.M. Kuiper, Ellen Werner, Elsemieke de Vries, Femke Boersma, Frank C. Bekkering, Frank H.J. Wolfhagen, Frank ter Borg, Frans J.C. Cuperus, Gemma X. Weijsters, Gijs J. de Bruin, Hajo J. Flink, Hanneke van Soest, Hans H.K. Thio, Harry L.A. Janssen, Hendrik J.M. de Jonge, Huseyin Aktas, Ingrid C.A.W. Konings, J. Marleen de Vree, J. (Netty) van Kemenade, Jan Maarten Vrolijk, Janne E. van Rooij, Jeroen D. van Bergeijk, Jerome Sint Nicolaas, Johan P.H. Kuyvenhoven, Johannes Schmidt‐Böhmer, Joost P.H. Drenth, Khalida Soufidi, Kirsten Boonstra, Laurens A. van der Waaij, L. (Bert) C. Baak, Leendert H. Oterdoom, Lisette J.H. van Dam, Ludger S.M. Epping, Paul J. Bus, Maaike J. Denters, Marcel Cazemier, Maria C. van Hooff, Maria N. Aparicio‐Pages, Marjo J. Kerbert‐Dreteler, Martijn J. ter Borg, Martine A.M.C. Baven‐Pronk, Matthias C. Jurgens, Matthijs Kramer, Menno Beukema, Merel M. Tielemans, Michael Klemt‐Kropp, Nicole F.M. van Gerven, Nicole S. Erler, Paul G. van Putten, Philip W. Friederich, Pieter C.J. ter Borg, Robert C. Verdonk, Remco van Dijk, Rob P.R. Adang, Robert Roomer, Rozanne C. de Veer, Sander de Kort, Sigrid Vandebosch, Stephan H.C. van Stiphout, Stephan Schmittgens, Sunje Abraham, Susanne L. Onderwater, Suzanne van Meer, Sven J. van den Hazel, Tiki D. Blom, Tim C.M.A. Schreuder, Tom J.G. Gevers, Ulrich Beuers, Ulrike de Wit, Wink de Boer, Yasser A. Alderlieste   +116 more
wiley   +1 more source

PMN can purloin a monocyte's zymosan without killing it.

, 2013
A. Monocyte (M) containing 6 zymosan. A. deformed (trapped) erythrocyte is at 12 o'clock. Four PMN are approaching. B. +6 min, 55 sec: PMN are surrounding the monocyte. C.
Anne Chevance de Boisfleury (427326), Stephen E. Malawista (272485)   +1 more
core   +1 more source

Factors released by LPS and/or Stx1-treated ASTs induce increased PMN adhesion and HUVECd toxicity.

, 2012
HUVECd were stimulated with CM-Control, CM−LPS, CM−Stx1 or CM−LPS+Stx1 for 24 h. Then, PMN were seeded onto pretreated HUVECd (CM-Control/PMN, CM−LPS/PMN; CM−Stx1/PMN or CM−LPS+Stx1/PMN).
Cecilia Calatayud (175470), Martín A. Isturiz (175476), Verónica I. Landoni (175459), Marcelo de Campos Nebel (175465), Pablo Schierloh (175463), Gabriela C. Fernández (175467), María J. Lapponi (175473)   +6 more
core   +1 more source

Neutrophil‐Macrophage Interactions Shape Inflammatory Macrophage Remodeling in Gastric Cancer During Chemo‐Immunotherapy

Cancer Science, EarlyView.
PD‐1 blockade combined with chemotherapy induces MHC‐II+ inflammatory neutrophils in gastric cancer, which engage in dynamic crosstalk with macrophages to remodel the tumor microenvironment toward a pro‐inflammatory state, thereby amplifying antitumor immune responses.
Keita H. Nagaoka, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Takuya Nakatsuru, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Sai M. Pulukuri, Yuko Ishii, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source