Results 111 to 120 of about 40,105 (240)

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

<i>In vivo</i> monitoring of polymorphonuclear myeloid-derived suppressor cells in experimental rheumatoid arthritis. [PDF]

Front Immunol
Schwenck J, Fuchs K, Ali Jarboui M, Geiger S, Neumann M, Öz HH, Carevic M, Hoffmann S, Hartl D, Griessinger CM, Gonzalez-Menendez I, Quintanilla-Martinez L, Henes J, Reischl G, Maurer A, Pichler BJ, Kneilling M.   +16 more
europepmc   +1 more source

Selective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy

The FEBS Journal, EarlyView.
As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley   +1 more source

A Cross‐Sectional Study on Apical Periodontitis in Root‐Filled Teeth: Do Clinically Available Factors Reflect Inflammation Level?

International Endodontic Journal, EarlyView.
ABSTRACT Aim Perceived severity of the condition is one of several factors influencing clinical decision‐making regarding the management of root‐filled teeth with persistent apical radiolucency. However, whether clinically available factors can indicate the severity of persistent apical lesions remains unclear, particularly in asymptomatic cases.
Jenny Olsson, Gunnar Warfvinge, Helena Fransson, Katarina Rydin, Anna Ljunggren   +4 more
wiley   +1 more source

Gut-liver axis in liver pre-metastatic niche formation: immune networks, microbial, and metabolic and emerging therapeutic opportunities. [PDF]

Front Microbiol
Zhao L, Lin Q, Zhang D, Liu Y, Zong M, Xi L, Xie F, Song S, Xue P, Zhu S, Chu X.   +10 more
europepmc   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

An ARG1-associated immunometabolic program in bone marrow PMN-MDSC-like cells in multiple sclerosis and experimental autoimmune encephalomyelitis. [PDF]

Front Immunol
Xie H, Fu Y, Bi Y, Han R, Liu P, He B, Chen B, Ren H.   +7 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Chronic stress drives tumorigenesis and progression via central nervous system-mediated neuroimmune circuits. [PDF]

Int J Oral Sci
Yang Z, Wang T, Tian X, Sun S, Xiang S, Hu Y, Yang D, Wang Y, Ye L, Xu H, Zhou X, Zeng X, Chen Q, Li J.   +13 more
europepmc   +1 more source