Results 191 to 200 of about 49,900 (290)

The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities. [PDF]

Mol Cancer
Zhang XR, Wei B, Jiang BH, Ren WH.
europepmc   +1 more source

Organ-specific pre-metastatic and metastatic niches in colorectal cancer: "discrepancy in response to immune checkpoint inhibitors in liver and lung metastasis". [PDF]

Front Immunol
Mourad M, Al Mahmasani L, Abbas N, Shamseddine A.   +3 more
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Divergent myeloid and lymphoid immune landscapes in HPV/p16 positive and HPV/p16 negative oropharyngeal squamous cell carcinomas and their lymph node metastases. [PDF]

Mol Med
Graessle R, Piwonski I, Franzen A, Olze H, Kühl AA, Hummel M, Erben U, Coordes A.   +7 more
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Hijacking the bone niche: mechanistic insights into bone metastasis in breast cancer. [PDF]

Bone Res
Wu J, Deng M, Ye F, Deng W, Wu Z, Zheng X, Song C, Zou Y, Tang H.   +8 more
europepmc   +1 more source

CD133 Shapes Extracellular Vesicle Cargo and Angiogenic Function in Basal‐Like Triple‐Negative Breast Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are central mediators of tumour‐stroma communication, yet the mechanisms governing their biogenesis and functional cargo remain poorly understood. Here, we identify CD133 (Prominin‐1), selectively expressed in basal‐like triple‐negative breast cancer (BL‐TNBC) cells, acts as a key organizer of EV production and ...
Mireia Gomez‐Duro, Ptissam Bergam, Sara Sanchez‐Redondo, Florent Dingli, Alix Zhou, Alain Joliot, Mengliang Ye, Marta Hergueta‐Redondo, Lucas Alves Tavares, Damarys Loew, Thierry Dubois, Lorena Martin‐Jaular, Hector Peinado, Graça Raposo, Gisela D'Angelo   +14 more
wiley   +1 more source

Can we identify which patients are likely to have septic arthritis with borderline synovial fluid cell counts? [PDF]

J Bone Jt Infect
Liu B, Raffetto M, Abbenhaus EJ, Hautala GS, Taylor WR, Bowers L, Matuszewski PE.   +6 more
europepmc   +1 more source

Tumour‐Derived Extracellular Vesicles Induce Diffuse Large B‐Cell Lymphoma Progression Through Macrophage‐Mediated MDSC Accumulation

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Elevated peripheral myeloid‐derived suppressor cells (MDSCs) predicted suppressed anti‐tumour immunity and poor prognosis in diffuse large B‐cell lymphoma (DLBCL) patients. Here we demonstrated that tumour‐derived extracellular vesicles (EVs) served as a messenger, delivering cholesterol from lymphoma cells to macrophages.
Mengke Liu, YingYu Dong, Qixiao Guan, JianBiao Wang, Qing Shi, RongGui Lin, Muchen Zhang, Di Fu, Shu Cheng, Pengpeng Xu, Eurydice Angeli, Guilhem Bousquet, Wenguo Cui, Hongjing Dou, Wei‐Li Zhao, Li Wang   +15 more
wiley   +1 more source

Comparing rates of primary medication nonadherence and turnaround time among patients at a health system specialty pharmacy compared with external specialty pharmacies. [PDF]

J Manag Care Spec Pharm
Cruchelow KR, Layne S, DeClercq J, Choi L, Zuckerman AD.   +4 more
europepmc   +1 more source