Results 51 to 60 of about 7,893 (75)

Abstract 3307: Multiomics analysis to uncover the mechanism of radiosensitization of AR-positive triple negative breast cancers with AR inhibition

Cancer Research, 2022
Purpose: Expression of the androgen receptor (AR) has been identified as a driver of tumor growth in triple negative breast cancers (TNBC), and previous work has nominated AR inhibition as a strategy for radiosensitization in AR+ TNBC. Despite its role
A. Michmerhuizen, A. Pesch, B. Chandler, L. Lerner, Connor Ward, Leah Moubadder, S. The, B. McBean, Caleb C. P. Cheng, Lori J Pierce, C. Speers   +10 more
semanticscholar   +1 more source

Abstract 3307: Real-world outcomes of first-line pembrolizumab monotherapy for PD-L1-positive (TPS ≥50%) metastatic non-small cell lung cancer (NSCLC)

Epidemiology, 2019
Introduction Pembrolizumab monotherapy was approved in October 2016 for first-line (1L) treatment of metastatic NSCLC with PD-L1 tumor proportion score (TPS) ≥50% based on KEYNOTE-024 (KN024) trial results.
V. Velcheti, S. Chandwani, Xin Chen, M. C. Pietanza, T. Burke   +4 more
semanticscholar   +1 more source

Abstract 3307: BRCA1 promoter methylation analyzed in 1032 primary breast cancers predicts favorable response to chemotherapy independently of p53 mutations

Molecular and Cellular Biology / Genetics, 2018
Individuals with germline mutations in the breast cancer susceptibility gene, BRCA1, are at increased risk of developing breast- and ovarian cancer. BRCA1 is involved in DNA double strand break repair (DSB) by homologous recombination (HR), an error-free
Olafur A. Stefansson, H. Hilmarsdóttir, K. Ólafsdóttir, L. Tryggvadottir, A. Sverrisdottir, J. Jónasson, J. Eyfjord, Sigurdsson Sb   +7 more
semanticscholar   +1 more source

Abstract 3307: Utilizing endocytosis as a predictive biomarker for ADCs

Cancer Research
Antibody drug conjugates (ADCs) consist of an antibody conjugated to a chemotherapeutic drug. These therapeutic compounds are designed to exert improved targeted toxicity as compared to conventional chemotherapy.
Anette Weyergang, Astrid Medhus, Kay Oliver Schink, Kristian Berg, O. Engebraaten   +4 more
semanticscholar   +1 more source

Potential anti-apoptotic response in the induced T regulatory cells in the burn vs. burn-plus-peritonitis-injured animals 3307

Journal of Immunology
Actions of the mediators and cell-cell interactions presumably lead to the inhibition of the CD4+CD25- effector T cell proliferation and IL-2 production.
Nadeem Fazal
semanticscholar   +1 more source

La subcontratación más allá del paradigma empresarial tradicional: el supuesto de una comunidad de propietarios ante sucesivas contratistas (A propósito de la STS 27 mayo 2022, Rº 3307/2020).

Trabajo y Empresa. Revista de Derecho del Trabajo
A propósito de la STS 27 mayo 2022 (Rº 3307/2020), nuestro Alto Tribunal confirma la aplicación del art. 42 ET ante un particular supuesto de hecho.
José María Ruz López
semanticscholar   +1 more source

Abstract 3307: Chemopotentiation by low dose fractionated radiation therapy in colon cancer cells

Tumor Biology, 2015
Response rates for patients with primary and metastatic colorectal cancer treated with modern chemotherapy regimens such as 5-FU, leucovorin, oxaliplatin (FOLFOX) have routinely exceeded 50% and are frequently as high as 60-70%.
Teresa Smith, P. Parekh, Elizabeth T. Chang, M. Chuong   +3 more
semanticscholar   +1 more source

Abstract 3307: c-Met targeting chaperone-mediated protein degrader for therapeutic intervention in NSCLC

Cancer Research
The interaction between E3 ligases and chaperones is crucial for proteostasis, regulating more than 10% of total proteasomes and over 30% of human E3 ligases (Kevei, 2017).
H. Chae, Jisun Kim, SunHye Lee, Ho Yoo, Hyun-Kyoung Kim, Young-Jin Yu   +5 more
semanticscholar   +1 more source

The Impact of Ancillary Ligand in Tris(β‐diketonato) Europium(III) Complexes on the Electroluminescence Colour and OLED Performance

European Journal of Inorganic Chemistry
Two new octacoordinated europium coordination complexes (EuCCs) with the general formula [Eu(DPTB)3(H2O)2] (EuCC1) and [Eu(DPTB)3BathPhen] (EuCC2) were developed by incorporating a push‐pull primary antenna β‐diketone 1‐(4‐(Diphenylamino)phenyl)‐4,4,4 ...
Rashid Ilmi, Xiaoyang Xia, J. D. Dutra, Gabriel Silva Santos, Liang Zhou, Wai‐Yeung Wong, Muhammad S. Khan   +6 more
semanticscholar   +1 more source

Environmentally friendly agar‐agar biomaterial‐based triboelectric nanogenerator for sustainable electronics

Environmental Progress & Sustainable Energy
For the development of advanced technologies, sustainable materials are getting much attention to develop self‐powered devices/battery‐free technology.
Omkar A. Patil, Sourabh B. Ghode, S. L. Patil, Mahesh Y. Chougale, Swapnil R. Patil, Chandrashekhar S. Patil, Amit A. Bagade, A. R. Sonkawade, A. Tiwari, Rajanish K. Kamat, Jinho Bae, T. Dongale   +11 more
semanticscholar   +1 more source