Results 31 to 40 of about 517 (110)

Effect of selected endocrine disrupters on T3-regulated endpoints in the hypothalamic-pituitary-thyroid hormone axis, and several of its regulated enzymes

, 2009
Der Körper kommt, teilweise unbemerkt, täglich mit pflanzlichen Inhaltsstoffen, Industrieprodukten und Chemikalien in Form von z.B. Plastikverpackungen, mit Insektiziden und Pflanzenschutzmitteln, sowie Kosmetika in Kontakt.
Nobis, Inga
core   +1 more source

A Review of Vagus Nerve Stimulation for Disease: Comprehensive Theory and Evidence for Mechanisms of Action

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu, Alex Liang, Benjamin U. Hoffman, Dawn M. Schiehser, Oliver Case, Alan Simmons, Ruth Klaming, Andres Gottfried‐Blackmore, Ravinder K. Mittal, Christopher Puleo, Hubert Lim, Imanuel Lerman   +11 more
wiley   +1 more source

Operational Development and Launch of an Adaptive Platform Trial in Amyotrophic Lateral Sclerosis: Processes and Learnings From the First Four Regimens of the HEALEY ALS Platform Trial

Muscle &Nerve, Volume 72, Issue 2, Page 294-305, August 2025.
ABSTRACT Introduction/Aims Platform trials present several advantages over traditional interventional clinical trials. Here, we provide a detailed description of the operational framework of the HEALEY ALS Platform Trial. Methods Platform‐level procedures for regulatory oversight, safety, and site management were developed prior to trial launch ...
Brittney A. Harkey, Sofia Distefano, Jaclyn A. Pagliaro, Lindsay Heyd, Marianne Chase, Courtney Igne, Hong Yu, Alexander V. Sherman, Derek Dagostino, Eric Tustison, Genevive Changkuon, Meghan Hall, Gale Kittle, Mariah R. Connolly, Elisa Giacomelli, Erica Scirocco, James D. Berry, Suma Babu, Jeremy Shefner, Eric A. Macklin, Lori B. Chibnik, Annette De Mattos, Kristin Drake, Cornelia Kamp, Andrew McGarry, Margherita Torti, Catherine Small, Allison Bulat, Merit E. Cudkowicz, Sabrina Paganoni, for the HEALEY ALS Platform Trial Study Group, Eric A. Macklin, Lori B. Chibnik, Douglas Hayden, Po‐Ying Lai, Rachel A. Donahue, Hao‐Wun Chen, Jianing Wang, Melanie Quintana, Benjamin R. Saville, Michelle A. Detry, Joe Marion, Matteo Vestrucci, Anna McGlothlin, Gustavo Alameda, Nithya Mathai, Eduardo Locatelli, Gabriela Lopes, Sabrina Paganoni, Merit Cudkowicz, Doreen Ho, Alexandra McCaffrey, James D. Berry, Suma Babu, Jennifer Scalia, Sarah Luppino, Clotilde Lagier‐Tourenne, Ghazaleh Sadri‐Vakili, Elisa Giacomelli, Erica Scirocco, Raina Chrobak, Adam Quick, Stephen Kolb, Sarah Heintzman, Senda Ajroud‐Driss, Robert Sufit, April Szymanski, Jonathan Katz, Liberty Jenkins, Daragh Heitzman, Alan Martin, Stanley H. Appel, (Simpson) Greene Ericka, Jason R. Thonhoff, Sheetal Shroff, Bing Liao, Kevin Felice, Charles Whitaker, Nicholas J. Maragakis, Lora L. Clawson, Alpa Uchil, Kristen M. Riley, JinAe Arneklev, Zachary Simmons, James Grogan, Xiaowei Su, Mansoureh Mamarabadi, Timothy M. Miller, Amber Malcolm, Nicholas Olney, Tracy Bazan, Michael D Weiss, Nassim Rad, Leo H. Wang, Stephen A. Goutman, Eva L. Feldman, Joseph Americo Fernandes, Ezequiel Piccione, Pariwat Thaisetthawatkul, Omar Jawdat, Constantine Farmakidis, Duaa Jabari, Jeffrey Statland, Mamatha Pasnoor, Mazen Dimachkie, Margaret Ayo Owegi, Robert H. Brown, Mehdi Ghasemi, Hajar Houmani, Catherine Douthwright, Kate Daniello, Laura A. Foster, Tuan Vu, Niraja Suresh, Jerrica Farias, I‐Hweii A. Chen, Hristelina Ilieva, Piera Pasinelli, Daniel S. Newman, Ximena Arcila‐Londono, Kara Steijlen, Carlayne E. Jackson MD, Ratna Bhavaraju‐Sanka, Shafeeq Ladha, Bill Jacobsen, Jourdan Milliard, Robert Bowser, Jeremy M. Shefner, Terry Heiman‐Patterson, Anahita Deboo, James B. Caress, Michael S. Cartwright, Andrea Swenson, Christopher Nance, Ludwig Gutmann, Jinsy Andrews, Julia Yasek, Matthew Harms, Amanda Peltier, Richard Lewis, Matthew Burford, Frank Diaz, Dominic Fee, David Shrilla, Matthew Elliott, Goran Rakocevic, Sarah Jones, Guillermo Solorzano, Richard Bedlack, Xiaoyan Li, Edward J. Kasarskis, Zabeen Mahuwala, (Vish) Mathur Kumaraswamy Vishakhadatta, MD Lauren Elman, Colin Quinn, Michael Baer, Jeffrey Rosenfeld, David Borg, Karthikeyan Bhuvaneswaran, Jasdeep Kaur, David Walk, Sam Maiser, Seward B. Rutkove, Courtney E. McIlduff, Paul Twydell, Andrew Mundwiler, Eufrosina Young, Jenny A. Meyer, Kristin Johnson, Pooja Rao, Kourosh Rezania, Betty Soliven, Raymond Roos, Namita A. Goyal, Ali A. Habib, Tahseen Mozaffar, Manisha Kak Korb, Jeffrey Mullen, Jeffrey A. Cohen, Elijah Stommel, Nathaniel M Robbins, Michael Benatar, Nathan Carberry, Volkan Granit, Raghav Govindarajan, Vovanti Jones, Christina N. Fournier, Jaimin S. Shah, Bjorn Oskarsson, Said R. Beydoun, Leila Darki, Rodrigo Rodriguez, James P. Wymer, Miguel Chuquilin, Whitney McNeely, Lindsay Zilliox, Montserrat Diaz‐Abad, Peter H. Jin, Chandana Chauhan, Shakti Nayar, Gary L. Pattee, James Bobenhouse, Jennifer Martinez‐Thompson, P. Staff Nathan, Ghazala Hayat, Luisa Arroyave, Abbey Bailey, Jesse Bailey, Victoria Barlow, Allison Bulat, Genevive Changkuon, Marianne Chase, Melissa Cirino, Derek Dagostino, Cristina Deignan, Emma Deirmendjian, Annette De Mattos, Sofia DiStefano, Kristin Drake, Michaela Estes, Kenneth Faulconer, Precious Figueroa‐Szostek, Tessa Garozzo, Brittney A. Harkey, Meredith Gibbons Hasenoehrl, Jennifer Henrique, Natalie Henrique, Samuel Hurwitz, Courtney Igne, Liam Irwin, Katie Jentoft, Boglarka Jordan, Igor Katsovskiy, Olga Kharakozova, Taylor Kolvek, Alexander Korin, Thuong La, Haining Li, Joey Nguyen, Ilya Novak, Ricardo Ortiz, Joe Ostrow, Jaclyn Pagliaro, Jack Palillo, Payal Patel, Janae Patterson, Minh Phan, Najla Popel, Lindsay Pothier, Serena Proueng, Jesse Rosenthal, Alexander V. Sherman, Catherine Small, Natalia Tarasenko, Mirna Thomas, Eric Tustison, Prasha Vigneswaran, Yusra Wahab, Isaac Whitworth, Spencer Wright, Hong Yu, Mariah Connolly, Diana De Santiago, Adrian Felix, Karly Garrett, Meghan Hall, Jenny Hamilton, Kamran Khan, Gale Kittle, Marlee Lovett, Linda Nelson, Marissa Pabon, Diana Rede, Patrick Bolger, Ahmed Fetouh, Joan Woodcook, Cornelia Kamp, Julie Kennedy, Andrew McGarry, Margherita Torti   +279 more
wiley   +1 more source

Update of the Scientific Opinion on the risks for human health related to the presence of perchlorate in food

EFSA Journal, Volume 23, Issue 5, May 2025.
Abstract The European Commission asked EFSA to update its 2014 risk assessment on perchlorate in food. Perchlorate is a contaminant of both natural and anthropogenic sources present in food and drinking water. It is a substrate for the sodium iodide symporter (NIS) and competitively inhibits the uptake of iodide into the thyroid.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Aleksandra Buha Djordjevic, Thorhallur Halldorsson, Chantra Eskes, Olaf Mosbach‐Schulz, Francesca Riolo, Elena Rovesti, Efisio Solazzo, Alexios Zormpas, Tuuli Tauriainen, James Kevin Chipman   +27 more
wiley   +1 more source

Over de gevolgen op lange termijn van kritieke ziekte bij kinderen en hoe deze beïnvloed worden door acute macronutriëntenrestrictie

, 2020
Children are admitted to the pediatric intensive care unit (PICU) when they acutely need vital organ support to avoid imminent death. Although most of the children need intensive care for only a few days and most of them seemingly recover well from the ...
Jacobs, An
core  

Ectopic expression of the grape hexose transporter VvHT5 restores STP13‐deficiency in Arabidopsis and promotes fungal resistance to Botrytis cinerea

Plant Pathology, Volume 74, Issue 2, Page 493-506, February 2025.
Expression of grapevine hexose transporter VvHT5 in Arabidopsis thaliana enhances resistance to Botrytis cinerea, suggesting a role in defence by restricting sugar availability to the pathogen and supporting host metabolic needs. Abstract Sugar transporters play a crucial role in plant responses to environmental factors.
Benoit Monnereau, Cécile Gaillard, Corentin Maslard, Pierre‐Antoine Noceto, Vincent Lebeurre, Anne Cantereau, Pierre Coutos‐Thévenot, Sylvain La Camera   +7 more
wiley   +1 more source

Safety and Efficacy of Combined Low Fluence Q-switched Nd:YAG 1064nm Laser with Pulsed Dye Laser 595nm in Melasma Control Among Malaysians: Does Adding Polynucleotides High Purification Technology (PN HPT™) Lead to a Difference?

Surgical Research
Background: Melasma is a form of acquired skin hyperpigmentation that is more prevalent among middle-aged women with Fitzpatrick skin types III, IV, and V. While highly preventable, the condition has a relatively high recurrence rate, especially with monotherapy.
Lim Lee Naa, Chew Phoay Koon, Yuen Shan Ling, Ng Poh Ling, Nicole Ng I, Ng Chia Wen, Adibah Hanim binti Ismail   +6 more
openaire   +1 more source

A Case of Rahnella aquatilis Bacteraemia After the Receipt of an Unlicensed Intravenous Vitamin Infusion, the First to be Reported in the UK

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Rahnella aquatilis is a Gram‐negative bacterium commonly found in the environment. Previously associated with food spoilage, it has in the past been responsible for causing infection in humans, usually as an opportunistic pathogen. We report a case of a previously healthy female who was diagnosed with R. aquatilis bacteraemia.
Amelia Benjamin, Partho Roy, Natalie Pedersen, Madhuri Vidwans, Dawei Cui   +4 more
wiley   +1 more source

Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic reticulum stress, and autophagy in hippocampus of western diet‐fed rats by modulation of systemic inflammation

BioFactors, Volume 50, Issue 6, Page 1236-1250, November/December 2024.
This study investigates the ability of Limosilactobacillus reuteri DSM 17938 (L. reuteri) in counteracting neuroinflammation, endoplasmic reticulum stress (ERS), and autophagy in hippocampus of rats fed a high fat and fructose diet. Diet‐induced pro‐inflammatory signaling pathway activation, ERS, and autophagy were prevented by L.
Arianna Mazzoli, Maria Stefania Spagnuolo, Francesca De Palma, Natasha Petecca, Angela Di Porzio, Valentina Barrella, Antonio Dario Troise, Rosanna Culurciello, Sabrina De Pascale, Andrea Scaloni, Gianluigi Mauriello, Susanna Iossa, Luisa Cigliano   +12 more
wiley   +1 more source

Kraftspektroskopie mittels optischer Pinzetten zur Untersuchung einzelner Rezeptor/Ligand-Komplexe

, 2013
Optische Pinzetten stellen neuartige Werkzeuge in der Biophysik dar, die sich durch eine außerordentliche Präzision auszeichnen. Im Rahmen der vorliegenden Arbeit werden verfeinerte Bildanalysetechniken vorgestellt und neu entwickelt, die es erlauben ...
Wagner, Carolin
core