Results 91 to 100 of about 133,257 (324)
Advanced Sensor Research, EarlyView.This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan +4 more
wiley +1 more source
Access to justice: the Palestinian legal system and the fragmentation of coercive power [PDF]
, 2004 In recent years there has been an increased interest amongst development practitioners in the potential role of law in situations of violent conflict. The Middle East has increasingly become the focus of this concern.
Kelly, Tobias
core
Uni-directional polymerization leading to homochirality in the RNA world [PDF]
, 2005 The differences between uni-directional and bi-directional polymerization are considered. The uni-directional case is discussed in the framework of the RNA world. Similar to earlier models of this type, where polymerization was assumed to proceed in a bi-
Andersen, A. C. +3 more
core +2 more sources
Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling
Advanced Science, EarlyView.ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li +12 more
wiley +1 more source
Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design
Advanced Science, 2022 Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands of options can be ...
Chengxi Li +6 more
doaj +1 more source
Labeling of Unique Sequences in Double-Stranded DNA at Sites of Vicinal Nicks Generated by Nicking Endonucleases [PDF]
, 2008 We describe a new approach for labeling of unique sequences within dsDNA under nondenaturing conditions. The method is based on the site-specific formation of vicinal nicks, which are created by nicking endonucleases (NEases) at specified DNA sites on ...
Frank-Kamenetskii, Maxim D., Kuhn, Heiko
core +3 more sources
A new concept in double duplex DNA invasion by chiral PNAs which simultaneously depress PNA-PNA and improve PNA-DNA duplex stability. [PDF]
Nucleic Acids Symposium Series, 2007 By using suitably designed chiral, lysine-based PNAs (chPNAs), the stability of complementary chPNAchPNA duplexes can be depressed, maintaining or improving at the same time the stability of the corresponding PNA-DNA duplexes. This approach could be used in order to develop chPNAs able to perform double duplex DNA invasion.
SFORZA, Stefano +3 more
openaire +3 more sources
Nanoscale Mapping of the Subcellular Glycosylation Landscape
Advanced Science, EarlyView.Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter +4 more
wiley +1 more source
On the Development of Early Algebraic Thinking [PDF]
, 2012 This article deals with the question of the development of algebraic thinking in young students. In contrast to mental approaches to cognition, we argue that thinking is made up of material and ideational components such as (inner and outer) speech ...
Radford, Luis
core +2 more sources
Strand invasion by mixed base PNAs and a PNA-peptide chimera [PDF]
Nucleic Acids Research, 2000 Peptide nucleic acid oligomers (PNAs) have a remarkable ability to invade duplex DNA at polypurine-polypyrimidine target sequences. Applications for PNAs in medicine and biotechnology would increase if the rules governing their hybridization to mixed base sequences were also clear.
X, Zhang, T, Ishihara, D R, Corey
openaire +2 more sources