Results 141 to 150 of about 2,353 (181)

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing. [PDF]

BMC Genomics
Soliman NS, Soliman MS, Khairat SM, Gad MA, Shawky S, Elkholy AA.   +5 more
europepmc   +1 more source

Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China. [PDF]

BMC Infect Dis
Wang J, Dong J, Chen Z, Xu Y, Qiu W, Chen S, Pei H, Zhong Y.   +7 more
europepmc   +1 more source

The pncA gene mutations of Mycobacterium tuberculosis in multidrug‐resistant tuberculosis

Biotechnology and Applied Biochemistry, 2021
AbstractThe pncA gene encodes pyrazinamidase enzyme which converts drug pyrazinamide to active form pyrazinoic acid, but mutations in this gene can prevent enzyme activity which leads to pyrazinamide resistance. The cross‐sectional study was carried out during 2016–2017 for 12 months.
Nasir Mahmood, Sadia Bhatti, Shahzada Nadeem Abbas, Saman Shahid, Sarah Bushra Nasir   +4 more
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pncA gene mutations in reporting pyrazinamide resistance among the MDR-TB suspects

Infection, Genetics and Evolution, 2018
Mutations in pncA gene contributing to PZA resistance was not clearly elucidated in China. To reveal the correlated mutations of pncA gene on pyrazinamide (PZA) resistance. 148 Mycobacterium tuberculosis clinical isolates were included from multi-drug resistant tuberculosis suspects.
Xiao‐Yuan Wu, Wei Lü, Yan Shao, Honghuan Song, Guoli Li, Yan Li, Limei Zhu, Cheng Chen   +7 more
openalex   +3 more sources

Characterization of novel Mycobacterium tuberculosis pncA gene mutations in clinical isolates from the Ukraine

Diagnostic Microbiology and Infectious Disease, 2018
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis cases in the Ukraine are increasing. Pyrazinamide (PZA) is critically important for first- and second-line tuberculosis (TB) treatment regimes. However, PZA drug susceptibility testing is time consuming and technically challenging.
L.T. Daum, OS Konstantynovska, Oleksii Solodiankin, Petro Poteiko, В. І. Болотін, JD Rodriguez, Anton Gerilovych, JP Chambers, Fischer Gw   +8 more
openalex   +3 more sources

Insights from the molecular mechanism of pyrazinamide to mutated pyrazinamidase linked to the pncA gene in clinical isolates of Mycobacterium tuberculosis

Journal of Biomolecular Structure and Dynamics, 2023
This study aims to conduct a comprehensive molecular dynamics strategy to evaluate whether mutations found in pyrazinamide monoresistant (PZAMR) strains of Mycobacterium tuberculosis (MTB) can potentially reduce the effectiveness of pyrazinamide (PZA) for tuberculosis (TB) treatment.
Dian Ayu Eka Pitaloka, Arfan Arfan, Dwi Syah Fitra Ramadhan, Lidya Chaidir   +3 more
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Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus

Nature Medicine, 1996
Naturally pyrazinamide (PZA)-resistant Mycobacterium bovis and acquired PZA-resistant M. tuberculosis strains lose pyrazinamidase (PZase). To investigate the molecular mechanism of PZA resistance, we have cloned the gene (pncA) encoding M. tuberculosis PZase.
Angelo Scorpio, Ying Zhang
openalex   +3 more sources

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[Studies on pncA gene mutations in M. tuberculosis isolates].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2002
To understand the mutations of pncA gene in M. tuberculosis isolates, and to evaluate their clinical value.Analyzing the pncA genes in 74 M. tuberculosis clinical isolates with PCR-SSCP and PCR-AS. M. tuberculosis strain H37Rv was used as control.32 drug-sensitive isolates all displayed normal pncA SSCP profile.
X, Wu, J, Zhang, M, Zhong
openaire   +1 more source

Detection of Mutations in Mycobacterium tuberculosis pncA Gene by Modified High-Resolution Melting Curve Analysis of PCR Products

Bulletin of Experimental Biology and Medicine, 2019
We developed a protocol for detection of mutations in the pncA gene associated with M. tuberculosis resistance to pyrazinamide by analyzing melting curves of 7 overlapping amplicons with artificial heteroduplex formation (H-HRM) formed by co-amplification of wild-type DNA and test DNA and compared its efficiency and robustness with those of classical ...
M L, Filipenko, M A, Dymova, A G, Cherednichenko, E A, Khrapov, O V, Mishukova, Ya Sh, Schwartz   +5 more
openaire   +2 more sources