Association between overexpression of efflux pumps genes Rv0191 and Rv3008 and pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis: a multi-center study [PDF]
BMC Infectious DiseasesBackground Pyrazinamide is a drug that helps shorten the duration of tuberculosis treatment. Mutations in the pncA are the most common mechanism of pyrazinamide resistance in M. tuberculosis.
Mohammad Hashemzadeh +4 more
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Pyrazinamide susceptibility testing in Mycobacterium tuberculosis: impact of false-positive BD MGIT 960 results and added value of sequencing for accurate diagnosis in a low-MDR-TB-incidence context [PDF]
Frontiers in Cellular and Infection MicrobiologyIntroductionThe reliability of phenotypic pyrazinamide (PZA) drug susceptibility test (DST) in Mycobacterium tuberculosis complex (MTBC) isolates is under growing scrutiny.
Touyana Semenova +12 more
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Molecules, 2016 A new cocrystal of pyrazinamide with oxalic acid was prepared mechanochemically and characterized by PXRD, Raman spectroscopy, solid-state NMR spectroscopy, DTA-TG, and SEM. Based on powder X-ray diffraction data the structure was solved.
Franziska Emmerling +2 more
exaly +3 more sources
PharmaceuticsExploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing the management of multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate the association between pyrazinamide exposure,
Judith Bruchfeld, , Bruchfeld Judith
exaly +3 more sources
Toward precision detection of pyrazinamide resistance: critical concentration assessment and rapid molecular method validation [PDF]
Frontiers in MicrobiologyThis study evaluated broth microdilution (BMD) and fluorescence PCR melting curve analysis (MeltPro MTB/PZA, targeting pncA mutations) for detecting pyrazinamide (PZA) resistance-associated mutations in rifampicin-resistant tuberculosis (RR-TB).
Yanfeng Zhao +11 more
doaj +2 more sources
Pyrazinamide resistance in rifampicin discordant tuberculosis.
PLoS ONE, 2022 IntroductionMycobacterium tuberculosis strains with phenotypically susceptible rpoB mutations (rifampicin discordant) have emerged following implementation of rapid molecular drug resistance testing for tuberculosis. Whilst rifampicin resistance is known
Nomonde Ritta Mvelase +3 more
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Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation. [PDF]
PLoS ONE, 2017 Pyrazinamide is the main driver of sterilizing effect in the standard regimen in adults and older children, and this effect is concentration-dependent. Tuberculosis patients co-infected with human immunodeficiency virus (HIV) have an increased risk for ...
Christopher Vinnard +9 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Objectives: This study was performed to develop a population pharmacokinetic model of pyrazinamide for Korean tuberculosis (TB) patients and to explore and identify the influence of demographic and clinical factors, especially geriatric diabetes mellitus
Ryunha Kim +23 more
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Adverse Drug Reactions to a Daily Fixed-dose Combination Based Antituberculosis Treatment Regime in India’s National Tuberculosis Elimination Programme: A Prospective Cohort Study [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: In India, the daily weight-based, Fixed Dose Combination (FDC) Antituberculosis Treatment (ATT) regime under the National Tuberculosis Elimination Programme (NTEP) was introduced, replacing the previous intermittent regime with the ...
Kapil Mate +2 more
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BMC Infectious Diseases, 2020 Background Pyrazinamide still may be a useful drug for treatment of rifampin-resistant (RR-TB) or multidrug-resistant tuberculosis (MDR-TB) in China while awaiting scale up of new drugs and regimens including bedaquiline and linezolid.
Hui Xia +6 more
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