Results 21 to 30 of about 25,215 (206)

Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis

Tropical Medicine and Infectious Disease, 2023
Background: Patients with tuberculosis (TB) may develop multi-organ failure and require admission to intensive care. In these cases, the mortality rates are as high as 78% and may be caused by suboptimal serum concentrations of first-line TB drugs.
Francisco Beraldi-Magalhaes, Suzanne L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Amanda Araujo Costa, Mariana Millan Fachi, Marcus Vinicius de Liz, Alexandra Brito de Souza, Izabella Picinin Safe, Roberto Pontarolo, Steven Wallis, Jeffrey Lipman, Jason A. Roberts, Marcelo Cordeiro-Santos   +14 more
doaj   +1 more source

Determination of pyrazinamide plasma concentrations using lc-ms and pharmacokinetics of pyrazinamide in patients with multidrug-resistant tuberculosis and in patients co-infected with multidrug-resistant tuberculosis and HIV [PDF]

, 2013
Magister Pharmaceuticae - MPharmTuberculosis and HIV are arguably South Africa’s largest and most important health issues. With drug-resistant strains of tuberculosis on the increase and little research on new drugs, there is an urgent need for research ...
Botha, Carla Ilse
core   +1 more source

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Studies of 3-(Phenylcarbamoyl)-pyrazine-2-carboxylic Acids

Molecules, 2017
Pyrazinamide, the first-line antitubercular drug, has been regarded the basic component of tuberculosis treatment for over sixty years. Researchers have investigated its effect on Mycobacterium tuberculosis for this long time, and as a result, new ...
Lucia Semelková, Petra Janošcová, Carlos Fernandes, Ghada Bouz, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, Jiří Kuneš, Martin Doležal, Jan Zitko   +10 more
doaj   +1 more source

Mutations in Efflux Pump Rv1258c (Tap) Cause Resistance to Pyrazinamide, Isoniazid, and Streptomycin in M. tuberculosis

Frontiers in Microbiology, 2019
Although drug resistance in Mycobacterium tuberculosis is mainly caused by mutations in drug activating enzymes or drug targets, there is increasing interest in the possible role of efflux in causing drug resistance.
Jiayun Liu, Jiayun Liu, Wanliang Shi, Shuo Zhang, Xiaoke Hao, Dmitry A. Maslov, Kirill V. Shur, Olga B. Bekker, Valery N. Danilenko, Ying Zhang   +9 more
doaj   +1 more source

Pyrazinamide phenotypic and genotypic drugs susceptibility results.

, 2022
Pyrazinamide phenotypic and genotypic drugs susceptibility results.
Nomonde Ritta Mvelase (13840309), Ravesh Singh (358400), Koleka Patience Mlisana (13840312), Khine Swe Swe-Han (6596060)   +3 more
core   +1 more source

Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry

Molecules, 2021
The urge for the development of a more efficient antibiotic crystalline forms led us to the disclosure of new antibiotic coordination frameworks of pyrazinamide, a well-known drug used for the treatment of tuberculosis, with some of the novel compounds ...
Sílvia Quaresma, Paula C. Alves, Patrícia Rijo, M. Teresa Duarte, Vânia André   +4 more
doaj   +1 more source

New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions

Molecules, 2014
A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions using microwave assisted synthesis methodology.
Ondrej Jandourek, Martin Dolezal, Jiri Kunes, Vladimir Kubicek, Pavla Paterova, Matus Pesko, Vladimir Buchta, Katarina Kralova, Jan Zitko   +8 more
doaj   +1 more source

Structure guided prediction of Pyrazinamide resistance mutations in pncA [PDF]

, 2020
Pyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing.
Karmakar, M, Ascher, DB, Horan, K, Rodrigues, CHM, Denholm, JT   +4 more
core   +3 more sources

In Situ Investigation of a Self-Accelerated Cocrystal Formation by Grinding Pyrazinamide with Oxalic Acid

Molecules, 2016
A new cocrystal of pyrazinamide with oxalic acid was prepared mechanochemically and characterized by PXRD, Raman spectroscopy, solid-state NMR spectroscopy, DTA-TG, and SEM. Based on powder X-ray diffraction data the structure was solved.
Hannes Kulla, Sebastian Greiser, Sigrid Benemann, Klaus Rademann, Franziska Emmerling   +4 more
doaj   +1 more source

Rechallenge after anti-tuberculosis drug-induced liver injury in a high HIV prevalence cohort

Southern African Journal of HIV Medicine, 2022
Background: There are limited data on the outcomes of rechallenge with anti-tuberculosis therapy (ATT) following anti-tuberculosis drug-induced liver injury (AT-DILI) in a high HIV prevalence setting.
Muhammed Shiraz Moosa, Gary Maartens, Hannah Gunter, Shaazia Allie, Mohamed F. Chughlay, Mashiko Setshedi, Sean Wasserman, David F. Stead, Karen Cohen   +8 more
doaj   +1 more source