Results 11 to 20 of about 25,215 (206)

Pyrazinamide-induced maculopapular rash

Indian Journal of Dermatology, 2010
Pyrazinamide is a commonly used first-line antitubercular drug. Gastric-related adverse drug reactions are common with pyrazinamide. Dermatological manifestations due to pyrazinamide are rare.
Khayyam Khalid, Imam Faisal, Sharma Manju, Pillai K, Behera D   +4 more
doaj   +2 more sources

Drug Exposure and Susceptibility of Pyrazinamide Correlate with Treatment Response in Pyrazinamide-Susceptible Patients with Multidrug-Resistant Tuberculosis

Pharmaceutics
Exploring the influence of pyrazinamide exposure and susceptibility on treatment response is crucial for optimizing the management of multidrug-resistant tuberculosis (MDR-TB). This study aimed to investigate the association between pyrazinamide exposure,
Shulan Dong, Ge Shao, Lina Davies Forsman, Sainan Wang, Shanshan Wang, Jiayi Cao, Ziwei Bao, Judith Bruchfeld, Jan-Willem C. Alffenaar, Jia Liu, Yi Hu, Meiying Wu   +11 more
doaj   +2 more sources

Optimizing pyrazinamide for the treatment of tuberculosis [PDF]

, 2021
Pyrazinamide is a potent sterilizing agent that shortens the treatment duration needed to cure tuberculosis. It is synergistic with novel and existing drugs for tuberculosis.
Morlock, Glenn, Aarnoutse, Robert, Stout, Jason E, Peloquin, Charles, Bliven-Sizemore, Erin, Weiner, Marc, Zhang, Nan, Boeree, Martin J., Savic, Radojka M, Dooley, Kelly E., Dooley, Kelly E, Heinrich, Norbert, Posey, James, Hoelscher, Michael, Kenzie, William Mac, Phillips, Patrick PJ, Whitworth, William, Peloquin, Charles A, Boeree, Martin J, Savic, Radojka M., Stout, Jason E.   +20 more
core   +1 more source

Pyrazinamide-3-Nitrophthalic Acid Cocrystals: Synthesis, Transformation, and Property Evaluation

, 2023
The generation of multiple stoichiometric cocrystals from safe and nontoxic water is a rare occurrence. This study explored three different stoichiometric cocrystals (1:1, 1:2, and 2:1) of pyrazinamide-3-nitrophthalic acid cocrystals characterized by ...
Xiaohan Li (276434), Yanyue Lu (17361982), Jinyan Zhang (759953), Shaochang Ji (17361976), Haiquan Jing (17361979), Jiayi Cheng (7464635), Zhihan Liang (17361973)   +6 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Protective role of taurine against hepatotoxicity induced by pyrazinamide in rats

National Journal of Physiology, Pharmacy and Pharmacology, 2018
Background: Pyrazinamide is a widely used antituberculosis drug. However, associated with its clinical use, hepatotoxicity is a life-threating side effect reported in some patients, but the exact mechanism by which pyrazinamide induces hepatotoxicity is ...
Shohreh Taziki, Vahid Khori, Mehrdad Jahanshahi, Akhtar Seifi, Fatemeh Babakordi Babakordi, Ensehgol Nikmahzar Nikmahzar   +5 more
doaj   +1 more source

Synthesis and Crystal Structures of Mn(II) and Co(II) Complexes as Catalysts for Oxidation of Cyclohexanone

Inorganics, 2022
The global demand on adipic usage in the production of plasticizers and synthetic polyamide is increasing. In line with the search for an efficient and energy-conserving way to isolate adipic acid (AA) in good yields, this paper introduces the ...
Adedibu C. Tella, Aaron Y. Isaac, Hadley S. Clayton, Adeniyi S. Ogunlaja, Aswathy T. Venugopalan, Marimuthu Prabu, Raja Thirumalaiswamy   +6 more
doaj   +1 more source

Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides

Pharmaceuticals, 2021
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication.
Ghada Bouz, Sarah Bouz, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko   +7 more
doaj   +1 more source

Pyrazinamide may possess cardioprotective properties [PDF]

, 2019
Pyrazinamide is an anti-tubercular agent, used as a part of a three-drug regime (any three of the following: rifampicin, isoniazid, pyrazinamide, streptomycin or ethambutol) for the initial phase of treatment.
Sukhodub, Andriy, Du, Qingyou, Sinha, Sharabh, Sofija Jovanović, Jovanovic, Sofija, Aleksandar Jovanović, Sharabh Sinha, Andriy Sukhodub, Qingyou Du, Jovanović, Aleksandar   +9 more
core   +1 more source

Relative Stability of Pyrazinamide Polymorphs Revisited: A Computational Study of Bending and Brittle Forms Phase Transitions in a Broad Temperature Range

Crystals, 2023
Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
doaj   +1 more source