Results 31 to 40 of about 26,737 (201)

Pyrazinamide phenotypic and genotypic drugs susceptibility results.

, 2022
Pyrazinamide phenotypic and genotypic drugs susceptibility results.
Nomonde Ritta Mvelase (13840309), Ravesh Singh (358400), Koleka Patience Mlisana (13840312), Khine Swe Swe-Han (6596060)   +3 more
core   +1 more source

New Potentially Active Pyrazinamide Derivatives Synthesized Under Microwave Conditions

Molecules, 2014
A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions using microwave assisted synthesis methodology.
Ondrej Jandourek, Martin Dolezal, Jiri Kunes, Vladimir Kubicek, Pavla Paterova, Matus Pesko, Vladimir Buchta, Katarina Kralova, Jan Zitko   +8 more
doaj   +1 more source

Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

Frontiers in Pharmacology, 2023
Background: The plasma concentrations of the four most commonly used first-line anti-tuberculosis (TB) drugs, isoniazid (INH), rifampicin (RMP), ethambutol (EMB), and pyrazinamide (PZA), are often not within the therapeutic range.
Lin Cheng, Ming Luo, Yan Guo, Yunfan Fan, Pengsen Wang, Gang Zhou, Shiwei Qin, Bangbi Weng, Peibo Li, Zhirui Liu, Songtao Liu   +10 more
doaj   +1 more source

In Situ Investigation of a Self-Accelerated Cocrystal Formation by Grinding Pyrazinamide with Oxalic Acid

Molecules, 2016
A new cocrystal of pyrazinamide with oxalic acid was prepared mechanochemically and characterized by PXRD, Raman spectroscopy, solid-state NMR spectroscopy, DTA-TG, and SEM. Based on powder X-ray diffraction data the structure was solved.
Hannes Kulla, Sebastian Greiser, Sigrid Benemann, Klaus Rademann, Franziska Emmerling   +4 more
doaj   +1 more source

Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes

mSystems, 2021
Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome ...
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar   +10 more
doaj   +1 more source

Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan [PDF]

, 2010
Thirty-six multidrug-resistant (MDR) Mycobacterium tuberculosis isolates collected in Japan were examined for pyrazinamide susceptibility and pyrazinamidase activity, and analysed by pncA sequencing and a hybridization-based line probe assay (LiPA ...
Kirikae, T., Sekiguchi, J.-I., Mori, T., Mitarai, S., Kato, S., Ando, H., Suetake, T., Kondo, Y.   +7 more
core   +1 more source

Structure guided prediction of Pyrazinamide resistance mutations in pncA [PDF]

, 2020
Pyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing.
Karmakar, M, Ascher, DB, Horan, K, Rodrigues, CHM, Denholm, JT   +4 more
core   +7 more sources

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Cytochrome P450 2E1/Nickel-Poly(propylene imine) dendrimeric nanobiosensor for pyrazinamide - A first line TB Drug [PDF]

, 2015
>Magister Scientiae - MScThe tuberculosis (TB) disease to this day remains one of the world’s prominent killerdiseases. Pyrazinamide (PZA) is one of the most commonly prescribed anti- tuberculosis (anti-TB) drugs due to its ability to significantly ...
Zosiwe, Mlandeli Siphelele Ernest
core   +1 more source

Precipitation of Zn(II)-Pyrazinamide Complex from Ethanol Solution as an Antibacterial Candidate based on Transitional Metal Complex Compounds

Indonesian Green Technology Journal
The Zn(II)-pyrazinamide complex compound is currently being developed as an antibacterial agent. To obtain the Zn(II)-pyrazinamide complex effectively, many factors must be considered, including the type of zinc(II) salt and the mole ratio.
Naila Azmi Adiba, Danar Purwonugroho, Yuniar Ponco Prananto   +2 more
doaj   +1 more source