Results 31 to 40 of about 25,215 (206)

Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients

Microbiology Spectrum, 2023
Prediction of susceptibility to pyrazinamide (PZA) directly from sputum has been challenging. The MeltPro MTB/PZA assay, based on melting curve analysis, can simultaneously detect Mycobacterium tuberculosis and the resistance to PZA from sputum. We aimed
Rong Li, Yang Li, Xinchang Chen, Lina Jia, Hongying Yu, Ya Huang, Qianhong Wu, Mingying Xiao, Shijia Ge, Yilin Zhang, Zhen Feng, Qingge Li, Ye Xu, Wenzhi Shi, Feng Sun, Wenhong Zhang   +15 more
doaj   +1 more source

The Phase Relationship Between the Pyrazinamide Polymorphs α and γ

, 2019
Pyrazinamide is an active pharmaceutical compound for the treatment of tuberculosis. It possesses at least four crystalline polymorphs. Polymorphism may cause solubility problems as the case of ritonavir has clearly demonstrated; however ...
Kangli, Li, Ivo, Rietveld, Josep-Lluis, Tamarit, Maria, Barrio, Benoît, Robert, Gabin, Gbabode, Marine, Vergé-Depré   +6 more
core   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

Cytochrome P450 2E1/Nickel-Poly(propylene imine) dendrimeric nanobiosensor for pyrazinamide - A first line TB Drug [PDF]

, 2015
>Magister Scientiae - MScThe tuberculosis (TB) disease to this day remains one of the world’s prominent killerdiseases. Pyrazinamide (PZA) is one of the most commonly prescribed anti- tuberculosis (anti-TB) drugs due to its ability to significantly ...
Zosiwe, Mlandeli Siphelele Ernest
core   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Pyrazinamide-induced acute gouty arthritis: a case report

, 2022
Gout is a common inflammatory and metabolic disease caused by the deposition of monosodium urate crystals in articular and non-articular tissues. Drugs used to treat tuberculosis, such as pyrazinamide and ethambutol, have been linked to hyperuricaemia ...
Emorinken, Airenakho, Ugheoke, Asuwemhe J.   +1 more
core   +1 more source

Precipitation of Zn(II)-Pyrazinamide Complex from Ethanol Solution as an Antibacterial Candidate based on Transitional Metal Complex Compounds

Indonesian Green Technology Journal
The Zn(II)-pyrazinamide complex compound is currently being developed as an antibacterial agent. To obtain the Zn(II)-pyrazinamide complex effectively, many factors must be considered, including the type of zinc(II) salt and the mole ratio.
Naila Azmi Adiba, Danar Purwonugroho, Yuniar Ponco Prananto   +2 more
doaj   +1 more source

Pharmacokinetic assessment of pyrazinamide and pyrazinoic acid in carbon tetrachloride-induced liver injury model in Wistar Rats

Journal of Pharmacy and Bioallied Sciences, 2023
Background: We investigated the pharmacokinetic behavior of pyrazinamide (PZA) and pyrazinoic acid (PA) in the presence of carbon-tetrachloride (CCl4) plus antitubercular treatment (ATT) drug-induced liver injury (DILI) in rats.
Swati Sharma, Vishal Sharma, Sunil Taneja, Alka Bhatia, Aishwarya Anand, Dibyajyoti Banerjee, Amol N Patil   +6 more
doaj   +1 more source

Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China

Infection and Drug Resistance, 2021
Shufang Lin,1 Shuzhen Wei,1 Yong Zhao,1 Zhisong Dai,1 Jian Lin,1 Yu Pang2 1Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 2Department of Bacteriology and ...
Lin S, Wei S, Zhao Y, Dai Z, Lin J, Pang Y   +5 more
doaj  

Characterization of pyrazinamide resistance in consecutive multidrug-resistant mycobacterium tuberculosis isolates in sweden between 2003 and 2015

International Journal of Mycobacteriology, 2017
Background: The first line anti-tuberculosis drug pyrazinamide (PZA) is important when treating PZA susceptible multidrug-resistant tuberculosis (MDR-TB). Several drug resistance surveys have however reported PZA resistance among a significant proportion
Mikael Mansjo, Jim Werngren, Sven Hoffner   +2 more
doaj   +1 more source