Results 51 to 60 of about 26,737 (201)

Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China

Frontiers in Microbiology, 2021
Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Kun Li, Kun Li, Zhongping Yang, Jing Gu, Ming Luo, Jiaoyu Deng, Yaokai Chen   +6 more
doaj   +1 more source

A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih, Anguraj Moulishankar, Chee Yan Choo, Khang Wen Goh, Chrismawan Ardianto, Azam Che Idris, Long Chiau Ming   +6 more
wiley   +1 more source

Role of Nigella Sativa Seeds on Pyrazinamide Induced Hepatotoxicity

Journal of Islamic International Medical College, 2019
Objective: To determine the hepatoprotective effect of Nigella sativa seeds in Pyrazinamide induced hepatic damage in albino mice. Study Design: An experimental study.
Amtul Hafeez , Akbar Waheed , Neelofar Yousaf
doaj  

Diagnosis and Management of Infectious Encephalitis in Adults: Guidelines From the European Academy of Neurology and European Society of Clinical Microbiology and Infectious Diseases

European Journal of Neurology, Volume 33, Issue 10, October 2026.
ABSTRACT Background Encephalitis is difficult to diagnose and manage, posing a challenge to clinicians. Since the last European guidelines were published in 2010, novel causes have emerged, diagnostic processes have evolved and treatments assessed which need to be reflected in updated guidelines.
Julia Granerod, Johann Sellner, Jean‐Paul Stahl, Sylviane Defres, Alexandra Mailles, Erich Schmutzhard, Elisabeth Aurelius, Thomas Whitfield, Luca Massacesi, Maarten J. Titulaer, Pille Taba, Benedict D. Michael, Tehmina Bharucha, Lance Turtle, Brendan Sargent, Arina Tamborska, Jonathan Cattrall, Yun Huang, Eva Maria Hodel, Suzannah Lant, Glynn Webb, Rajish S. K. Shil, Shalley Dhar, Diederik van de Beek, Marie Studahl, Matthijs C. Brouwer, Uta Meyding‐Lamade, Ava Easton, Bhagteshwar Singh, Tom Solomon   +29 more
wiley   +1 more source

Tuberculosis Misdiagnosed as Bronchogenic Carcinoma: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT The patient, a 77‐year‐old male smoker, presented to the Emergency Department with dyspnea, cough, fever, night sweats, and 12 kg weight loss, initially suggesting COPD or lung cancer. Chest CT revealed a right upper lobe mass, pleural effusion, and lymphadenopathy, prompting suspicion of malignancy.
Pejman Hosseinzadeh, Sara Samadi, Shirin Taraz Jamshidi, Sayed Mortaza Fayez, Mahnaz Mozdourian   +4 more
wiley   +1 more source

Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment [PDF]

, 2004
Severe liver injury has been attributed to preventive treatment of latent tuberculosis infection with a 2-month course of rifampin-pyrazinamide. A retrospective cohort study in The Netherlands compared the hepatotoxicity of preventive treatment with ...
Kik, S., Mensen, Marlies, Cobelens, Frank, van Gerven, Paul, Keizer, S., Cobelens, F.G.J., van Hest, Rob, Kalisvaart, Nico, Keizer, Sytze, Trompenaars, Marie-Christine, van Gerven, P., Mensen, M.E.A., Borgdorff, M.W., Kik, Sandra, Borgdorff, Martien, Baars, H., Kalisvaart, N., van Hest, E., Trompenaars, M-C., Baars, Hennie   +19 more
core   +2 more sources

Clinical guideline highlights for the hospitalist: Updates on the treatment of drug‐susceptible and drug‐resistant tuberculosis

Journal of Hospital Medicine, EarlyView.
Allison Stickles, Anna Poston‐Blahnik, Elizabeth Schlaudecker, Moises Huaman   +3 more
wiley   +1 more source

A Painful Purpuric Rash in a Febrile Smoker

JEADV Clinical Practice, EarlyView.
Eugerta Dilka, Ina Sotiri, Irda Rrugeja, Monika Fida   +3 more
wiley   +1 more source

Pott's Spine Presenting With Concurrent Paraspinal, Retropharyngeal, and Wrist Abscesses: A Rare Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Spinal tuberculosis may present atypically with multifocal cold abscesses without neurological deficit or constitutional symptoms. Concurrent lumbosacral paraspinal, retropharyngeal, and wrist abscesses, though rare, should raise suspicion for tuberculosis, and early diagnosis with MRI and GeneXpert enables effective minimally invasive ...
Bibek Shrestha, Sangam Neupane, Nikhil Ranjan Das, Subodh Acharya, Santosh Khadka, Shrawan Dhungana, Dinesh Kafle   +6 more
wiley   +1 more source

LEVEL OF URIC ACID IN BLOOD SERUM OF NEW PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE

Туберкулез и болезни лёгких, 2017
The level of uric acid in blood serum was investigated in 134 new patients suffering from multiple drug resistant pulmonary tuberculosis (78 men and 56 women). The tests were performed by admission to hospital and then repeated in 1, 2, 3, 4, 5, 6, 7 and
R. Yu. Аbdullaev, O. G. Komissarova, E. S. Chumakova, V. S. Odinet   +3 more
doaj   +1 more source