Results 51 to 60 of about 25,215 (206)

Pyrazinamide induced thrombocytopenia

, 2010
Thrombocytopenia is an uncommon but potentially life-threatening complication of certain antitubercular drugs and is characterized by rapid destruction of platelets whenever offending drug is taken by a susceptible person.
Rajendra Prasad, Kant, Surya, SunishC Anand, Verma, Sanjay Kumar, Gupta, Vaibhav, Anand, Sunish C., SanjayKumar Verma, Surya Kant, Prasad, Rajendra, Vaibhav Gupta   +9 more
core   +2 more sources

Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan

, 2010
Thirty-six multidrug-resistant (MDR) Mycobacterium tuberculosis isolates collected in Japan were examined for pyrazinamide susceptibility and pyrazinamidase activity, and analysed by pncA sequencing and a hybridization-based line probe assay (LiPA ...
Kirikae, T., Sekiguchi, J.-I., Mori, T., Mitarai, S., Kato, S., Ando, H., Suetake, T., Kondo, Y.   +7 more
core   +1 more source

Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation

Molecules, 2017
Aminodehalogenation of 3-chloropyrazine-2-carboxamide with variously substituted benzylamines yielded a series of fifteen 3-benzylaminopyrazine-2-carboxamides. Four compounds possessed in vitro whole cell activity against Mycobacterium tuberculosis H37Rv
Ondrej Jandourek, Marek Tauchman, Pavla Paterova, Klara Konecna, Lucie Navratilova, Vladimir Kubicek, Ondrej Holas, Jan Zitko, Martin Dolezal   +8 more
doaj   +1 more source

5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation

Molecules, 2020
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year.
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko   +8 more
doaj   +1 more source

Esophageal Tuberculosis in an Elderly Woman

Gut Medicine, EarlyView.
Guanghao He, Rui Zhang, Ting Yan, Fei Gao, Xingshun Qi   +4 more
wiley   +1 more source

The Role of Pharmacovigilance Database in Identifying Antibiotic Resistance and Inappropriate Use: An Analysis of VigiBase Reports From Lower‐Middle‐Income Countries

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Background Digital databases such as pharmacovigilance (PV) databases could provide unique opportunities to monitor trends in suspected antibiotic resistance, ineffectiveness, and misuse, extending beyond their traditional role of tracking adverse drug reactions (ADRs).
Hager Saleh, Joseph Mitchell, Cecilia Stålsby Lundborg, Megha Sharma   +3 more
wiley   +1 more source

‘ZS-MDR-TB’ versus ‘ZR-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

Emerging Microbes and Infections, 2012
Indispensable for shortening treatment of drug-susceptible tuberculosis (TB), pyrazinamide (PZA, Z) is also essential in the treatment of multidrug-resistant (MDR)-TB. While resistance to PZA in MDR-TB is associated with poor treatment outcome, bacillary
Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson, Wenhong Zhang   +8 more
doaj   +1 more source

Acute Endobronchial Dissemination of a Tuberculoma Following EBUS‐GS‐Guided Transbronchial Biopsy: A Case Report

Respirology Case Reports, Volume 14, Issue 6, June 2026.
Acute endobronchial dissemination highly suggestive of a procedure‐associated event occurred after EBUS‐GS‐guided biopsy of a pulmonary tuberculoma. Because tuberculoma may mimic lung cancer, clinicians should consider tuberculosis in solitary nodules and monitor carefully for dissemination after bronchoscopy when necrotic lesions are sampled ...
Haruno Tsukagoshi, Yasuto Ueda, Tatsuya Nakada, Takashi Sumikawa, Yasuyuki Hasegawa, Mizuho Matsushita, Hiroki Chikumi, Akira Yamasaki   +7 more
wiley   +1 more source

Vegetating Lupus Vulgaris in a Child

JEADV Clinical Practice, EarlyView.
Viktor Pushkarenko, Yana‐Karina Zovdun, Olga Pushkarenko   +2 more
wiley   +1 more source

Thiazolidinedione–Pyrazolopyrimidinone Molecular Hybrids With Alkyl Spacers: Potential Antitubercular Agents Complemented by Molecular Modeling

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
We report the synthesis of 21 novel thiazolidinedione–pyrazolopyrimidinone derivatives (12a–u), prepared by coupling thiazolidinedione and pyrazolopyrimidinone pharmacophores through various alkyl linkers. The compounds were characterized spectroscopically and evaluated against the Mtb H37Rv strain, identifying compounds 5c and 5d as potent ...
Pule Seboletswe, Gobind Kumar, Nontobeko Gcabashe, Sanjeev Dhawan, Neha Manhas, Ankit, Audrey Jordaan, Digby F. Warner, Parvesh Singh   +8 more
wiley   +1 more source