Results 1 to 10 of about 2,990 (173)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error [PDF]

FEBS Open Bio
Nicotinamidases (PncA) catalyze the hydrolysis of nicotinamide to nicotinic acid, a key step in NAD+ salvage pathways. In the Lyme disease spirochete Borrelia burgdorferi, the plasmid‐encoded gene bbe22 encodes a PncA enzyme that is essential for ...
Kalvis Brangulis
doaj   +3 more sources

Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China [PDF]

Microbiology Spectrum
To investigate the effects of mutations on pyrazinamide (PZA)-associated regions, including pncA, rpsA, panD, and clpC1, among multidrug-resistant tuberculosis (MDR-TB) isolates from China.
Xiang-long Bo, Ma-chao Li, Hao Hang, Shi-qiang Lin, Hai-can Liu, Cheng Qian, Gui-lian Li, Xiu-qin Zhao, Kang-Lin Wan, Li-li Zhao   +9 more
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The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates [PDF]

Microorganisms
Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challenges diagnostic ...
H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yamin Gao, Shuai Wang, Xinwen Chen, Nanshan Zhong, Htin Lin Aung, Jinxing Hu, Tianyu Zhang   +9 more
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Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism [PDF]

Clinical and Translational Medicine
Background Fucosyltransferase 2 (FUT2)‐dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance.
Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu   +9 more
doaj   +2 more sources

Predicting pyrazinamide resistance in Mycobacterium tuberculosis using a graph convolutional network [PDF]

BMC Microbiology
Background Pyrazinamide is an important first-line antibiotic for treating tuberculosis, with resistance primarily driven by mutations in the pncA gene. Traditional machine learning models are able to predict pyrazinamide resistance with some success but
Dylan Dissanayake, Viktoria Brunner, Dylan Adlard, Joseph A. Morrone, Philip W. Fowler   +4 more
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Prevalence and Clinical Implications of Pyrazinamide Resistance in Newly Diagnosed TB Patients in Uganda [PDF]

Infection and Drug Resistance
Christopher Ndawula, Nalumaga Pauline Petra, Fredrickson B Wasswa, Joel Bazira Department of Microbiology, Mbarara University of Science and Technology, Mbarara, 1410, UgandaCorrespondence: Joel Bazira, Email jbazira@must.ac.ugBackground: Globally, 10.8 ...
Ndawula C, Petra NP, Wasswa FB, Bazira J
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Regulation of enteroendocrine cell respiration by the microbial metabolite hydrogen sulfide

Frontiers in Endocrinology, 2023
Endocrine functions of the gut are supported by a scattered population of cells, the enteroendocrine cells (EECs). EECs sense their environment to secrete hormones in a regulated manner.
Pierre Larraufie, Pierre Larraufie, Kenza Haroun, Carla Fleury, Mireille Andriamihaja, François Blachier   +5 more
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Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China

Frontiers in Microbiology, 2021
Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Kun Li, Kun Li, Zhongping Yang, Jing Gu, Ming Luo, Jiaoyu Deng, Yaokai Chen   +6 more
doaj   +1 more source

Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

Scientific Reports, 2021
To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet.
Joanna Moro, Catherine Chaumontet, Patrick C. Even, Anne Blais, Julien Piedcoq, Claire Gaudichon, Daniel Tomé, Dalila Azzout-Marniche   +7 more
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Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

Biomedicines, 2022
Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals.
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jérôme, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis   +11 more
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