Results 1 to 10 of about 2,835 (113)

Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China

Frontiers in Microbiology, 2021
Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Jiaoyu Deng, Yaokai Chen
exaly   +3 more sources

The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates [PDF]

Microorganisms
Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challenges diagnostic ...
H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yamin Gao, Shuai Wang, Xinwen Chen, Nanshan Zhong, Htin Lin Aung, Jinxing Hu, Tianyu Zhang   +9 more
doaj   +2 more sources

Intestinal Fut2 deficiency exacerbated alcohol‐related liver disease by disrupting nicotinamide metabolism [PDF]

Clinical and Translational Medicine
Background Fucosyltransferase 2 (FUT2)‐dependent fucosylation of intestinal epithelial cells is vital for preserving gut barrier integrity and microbial balance.
Liuying Chen, Zhongwei Yin, Luorui Shang, Hang Yuan, Wenkang Gao, Shuhan Wang, Shuyan Wang, Xiaohua Hou, Shenglan Yang, Huikuan Chu   +9 more
doaj   +2 more sources

Predicting pyrazinamide resistance in Mycobacterium tuberculosis using a graph convolutional network [PDF]

BMC Microbiology
Background Pyrazinamide is an important first-line antibiotic for treating tuberculosis, with resistance primarily driven by mutations in the pncA gene. Traditional machine learning models are able to predict pyrazinamide resistance with some success but
Dylan Dissanayake, Viktoria Brunner, Dylan Adlard, Joseph A. Morrone, Philip W. Fowler   +4 more
doaj   +2 more sources

Prevalence and Clinical Implications of Pyrazinamide Resistance in Newly Diagnosed TB Patients in Uganda [PDF]

Infection and Drug Resistance
Christopher Ndawula, Nalumaga Pauline Petra, Fredrickson B Wasswa, Joel Bazira Department of Microbiology, Mbarara University of Science and Technology, Mbarara, 1410, UgandaCorrespondence: Joel Bazira, Email jbazira@must.ac.ugBackground: Globally, 10.8 ...
Ndawula C, Petra NP, Wasswa FB, Bazira J
doaj   +2 more sources

Deep learning with photonic neural cellular automata [PDF]

Light: Science & Applications
Rapid advancements in deep learning over the past decade have fueled an insatiable demand for efficient and scalable hardware. Photonics offers a promising solution by leveraging the unique properties of light.
Gordon H. Y. Li, Christian R. Leefmans, James Williams, Robert M. Gray, Midya Parto, Alireza Marandi   +5 more
doaj   +2 more sources

Regulation of enteroendocrine cell respiration by the microbial metabolite hydrogen sulfide

Frontiers in Endocrinology, 2023
Endocrine functions of the gut are supported by a scattered population of cells, the enteroendocrine cells (EECs). EECs sense their environment to secrete hormones in a regulated manner.
Pierre Larraufie, Pierre Larraufie, Kenza Haroun, Carla Fleury, Mireille Andriamihaja, François Blachier   +5 more
doaj   +1 more source

Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

Scientific Reports, 2021
To study, in young growing rats, the consequences of different levels of dietary protein deficiency on food intake, body weight, body composition, and energy balance and to assess the role of FGF21 in the adaptation to a low protein diet.
Joanna Moro, Catherine Chaumontet, Patrick C. Even, Anne Blais, Julien Piedcoq, Claire Gaudichon, Daniel Tomé, Dalila Azzout-Marniche   +7 more
doaj   +1 more source

The effect of social norms on vegetarian choices is moderated by intentions to follow a vegetarian diet in the future: Evidence from a laboratory and field study

Frontiers in Psychology, 2023
Social norms could be a tool in dietary transition toward more sustainable diets, but the results of social norms interventions aimed at encouraging the selection of plant-based foods to date have been inconsistent.
Alya Hammami, Armelle Garcia, Nicolas Darcel, Suzanne Higgs, Olga Davidenko   +4 more
doaj   +1 more source

Dopamine Modulates the Processing of Food Odour in the Ventral Striatum

Biomedicines, 2022
Food odour is a potent stimulus of food intake. Odour coding in the brain occurs in synergy or competition with other sensory information and internal signals.
Olivier Rampin, Audrey Saint Albin Deliot, Christian Ouali, Jasmine Burguet, Elisa Gry, Gaelle Champeil Potokar, Nathalie Jérôme, Olga Davidenko, Nicolas Darcel, Vincent Bombail, Philippe Andrey, Isabelle Denis   +11 more
doaj   +1 more source