Results 21 to 30 of about 2,913 (168)

Analysis of pncA gene expression in pyrazinamide-resistant and multidrug-resistant Mycobacterium tuberculosis [PDF]

Xin yixue, 2023
Objective To compare the expression levels of pncA gene in pyrazinamide （PZA）-resistant and multidrug-resistant Mycobacterium tuberculosis before and after PZA drug stimulation， and to explore the relationship between PZA-resistant Mycobacterium ...
Wang Nan，, Yang Yu, Deng Ling, Wu Hui, Liu Zhihui, Meng Fanrong
doaj   +1 more source

Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy [PDF]

American Journal of Respiratory and Critical Care Medicine, 2018
Pyrazinamide (PZA), which is an analogue of nicotinamide, is an important first-line drug used in the short-course treatment of tuberculosis. PZA is a prodrug devoid of significant antibacterial activity. It is metabolized into its active form, pyrazinoic acid (POA), by the amidase activity of the Mycobacterium tuberculosis nicotinamidase ...
Malancha Karmakar, Maria Globan, Janet A. M. Fyfe, Timothy P. Stinear, Paul D. R. Johnson, Natasha E. Holmes, Justin T. Denholm, David B. Ascher   +7 more
openaire   +4 more sources

Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance

Current Issues in Molecular Biology, 2022
Without the proper information on pyrazinamide (PZA) susceptibility of Mycobacterium tuberculosis (MTB), PZA is inappropriately recommended for the treatment of both susceptible and multidrug-resistant tuberculosis (MDR-TB) in Nepal.
Dipti Shrestha, Bhagwan Maharjan, Jeewan Thapa, Mwangala Lonah Akapelwa, Precious Bwalya, Joseph Yamweka Chizimu, Chie Nakajima, Yasuhiko Suzuki   +7 more
doaj   +1 more source

Mechanisms of Antibiotic Resistance and Novel Therapeutic Approaches for <i>Mycobacterium tuberculosis</i>: A Narrative Review With a Focus on Tuberculosis Mutations in Iran. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is a highly contagious disease and one of the leading causes of mortality globally. The emergence and dissemination of multidrug‐resistant (MDR) strains of M. tuberculosis have become a major concern, especially in developing countries.
Bodaghi AB, Shariati A, Shamseddin J, Bodaghi AB, Rezaei M, Farahani A.   +5 more
europepmc   +2 more sources

Phenotypic Characterization of pncA Mutants of Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 2000
ABSTRACT We examined the correlation of mutations in the pyrazinamidase (PZase) gene ( pncA ) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis.
G P, Morlock, J T, Crawford, W R, Butler, S E, Brim, D, Sikes, G H, Mazurek, C L, Woodley, R C, Cooksey   +7 more
openaire   +2 more sources

Plant and Animal Protein Intakes Largely Explain the Nutritional Quality and Health Value of Diets Higher in Plants: A Path Analysis in French Adults

Frontiers in Nutrition, 2022
Diets higher in plants are associated with lower risks of chronic diseases. However, animal foods, which are rich in protein, are also rich in some important minerals and vitamins.
Elie Perraud, Juhui Wang, Marion Salomé, Jean-François Huneau, Nathanaël Lapidus, François Mariotti   +5 more
doaj   +1 more source

Plant to animal protein ratio in the diet: nutrient adequacy, long-term health and environmental pressure

Frontiers in Nutrition, 2023
BackgroundAnimal and plant protein sources have contrasting relationships with nutrient adequacy and long-term health, and their adequate ratio is highly debated.ObjectiveWe aimed to explore how the percentage of plant protein in the diet (%PP) relates ...
Hélène Fouillet, Alison Dussiot, Elie Perraud, Juhui Wang, Jean-François Huneau, Emmanuelle Kesse-Guyot, François Mariotti   +6 more
doaj   +1 more source

Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior

RSC Advances, 2020
We performed several analyses to unveil the pyrazinamide-resistance mechanism of R123P, T76P, G150A, and H71R mutants through molecular dynamics simulations.
Arif Ali, Muhammad Tahir Khan, Abbas Khan, Sajid Ali, Sathishkumar Chinnasamy, Khalid Akhtar, Athar Shafiq, Dong-Qing Wei   +7 more
openaire   +3 more sources

pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis [PDF]

Tuberculosis, 2013
Mutations in the pyrazinamidase (PZAse) coding gene, pncA, have been considered as the main cause of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis. However, recent studies suggest there is no single mechanism of resistance to PZA. The pyrazinoic acid (POA) efflux rate is the basis of the PZA susceptibility Wayne test, and its quantitative
Sheen, Patricia, Lozano, Katherine, Gilman, Robert H, Valencia, Hugo J, Loli, Sebastian, Fuentes, Patricia, Grandjean, Louis, Zimic, Mirko   +7 more
openaire   +3 more sources

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide

Nature Communications, 2017
AbstractTuberculosis chemotherapy is dependent on the use of the antibiotic pyrazinamide, which is being threatened by emerging drug resistance. Resistance is mediated through mutations in the bacterial gene pncA. Methods for testing pyrazinamide susceptibility are difficult and rarely performed, and this means that the full spectrum of pncA alleles ...
Yadon, Adam N., Rubin, Eric, Maharaj, Kashmeel, Adamson, John H., Lai, Yi-Pin, Sacchettini, James C., Ioerger, Thomas R., Pym, Alexander S.   +7 more
openaire   +5 more sources