Results 21 to 30 of about 5,852 (197)
International Journal of Mycobacteriology, 2019 Background: This study explored the genetic diversity of Mycobacterium tuberculosis isolates in Egypt by spoligotyping in combination with pncA gene sequencing, spoNC. Methods: First, isolates were selected from 400 isolates positive for M.
Suzan Ismail +4 more
doaj +3 more sources
Pyrazinamide Resistance and pncA Mutation Profiles in Multidrug Resistant Mycobacterium Tuberculosis
Infection and Drug Resistance, 2022 Dawei Shi,1,* Qiulong Zhou,2,* Sihong Xu,1 Yumei Zhu,3 Hui Li,4 Ye Xu2 1National Institutes for Food and Drug Control, Institute of Pathogen Biology at the Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s ...
Shi D, Zhou Q, Xu S, Zhu Y, Li H, Xu Y
doaj +3 more sources
Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing [PDF]
Journal of Clinical Microbiology, 2019 An in-house-developed pncA sequencing assay for analysis of pyrazinamide (PZA) resistance was evaluated using 162 archived Mycobacterium tuberculosis complex (MTBC) isolates with phenotypic PZA susceptibility profiles that were well defined by analysis of Bactec MGIT 960 PZA kit and PZase ...
Kingsley King-Gee Tam +7 more
openaire +4 more sources
Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan [PDF]
BMC Infectious Diseases, 2019 Background Pyrazinamide (PZA) is an important component of first-line drugs because of its distinctive capability to kill subpopulations of persistent Mycobacterium tuberculosis (MTB).
Muhammad Tahir khan +6 more
doaj +2 more sources
BMC Infectious Diseases, 2017 Background The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies.
Sarah Sengstake +8 more
doaj +5 more sources
pncAMutations in the Specimens from Extrapulmonary Tuberculosis [PDF]
Tuberculosis and Respiratory Diseases, 2012 Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was noted between the loss of PZase activity and PZA resistance.
Jaechun Lee +7 more
openaire +2 more sources
Microorganisms, 2022 The intestinal microbiota metabolic activity towards the available substrates generates myriad bacterial metabolites that may accumulate in the luminal fluid. Among them, indole and indole-related compounds are produced by specific bacterial species from
Naouel Tennoune +2 more
doaj +1 more source
Mechanisms of Antibiotic Resistance and Novel Therapeutic Approaches for <i>Mycobacterium tuberculosis</i>: A Narrative Review With a Focus on Tuberculosis Mutations in Iran. [PDF]
Health Sci RepABSTRACT Background and Aims Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is a highly contagious disease and one of the leading causes of mortality globally. The emergence and dissemination of multidrug‐resistant (MDR) strains of M. tuberculosis have become a major concern, especially in developing countries.
Bodaghi AB +5 more
europepmc +2 more sources
Phenotypic Characterization of pncA Mutants of Mycobacterium tuberculosis [PDF]
Antimicrobial Agents and Chemotherapy, 2000 ABSTRACT We examined the correlation of mutations in the pyrazinamidase (PZase) gene ( pncA ) with the pyrazinamide (PZA) resistance phenotype with 60 Mycobacterium tuberculosis isolates. PZase activity was determined by the method of Wayne (L. G. Wayne, Am. Rev. Respir. Dis.
G P, Morlock +7 more
openaire +2 more sources
Frontiers in Nutrition, 2022 Diets higher in plants are associated with lower risks of chronic diseases. However, animal foods, which are rich in protein, are also rich in some important minerals and vitamins.
Elie Perraud +5 more
doaj +1 more source