Results 11 to 20 of about 2,913 (168)
BMC Infectious Diseases, 2001 Background Pyrazinamide (PZA) is among the first-line drugs for the treatment of tuberculosis. In vitro, it kills semidormant mycobacteria only at low pH.
Kim Cheol Min +8 more
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Characteristics of
BMC Infectious Diseases, 2011 Background Pyrazinamide (PZA) is an important first-line drug in multidrug-resistant tuberculosis (MDRTB) treatment. However, the unreliable results obtained from traditional susceptibility testing limits its usefulness in clinical settings.
Lee Yu-Chin +5 more
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INSERSI GEN pncA KE DALAM PLASMID pGEM-T
Jurnal Kimia Riset, 2016 . Multidrug-resistant tuberculosis (MDR-TB) is among the most worrisome elements of the pandemic of antibiotic resistance. As the first line drug, pyrazinamide is often used to treat TB desease so there are many case of TB resistant to pyrazinamide. The
Eli Hendrik Sanjaya
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International Journal of Mycobacteriology, 2019 Background: This study explored the genetic diversity of Mycobacterium tuberculosis isolates in Egypt by spoligotyping in combination with pncA gene sequencing, spoNC. Methods: First, isolates were selected from 400 isolates positive for M.
Suzan Ismail +4 more
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Novel Mutations in pncA Gene of Pyrazinamide Resistant Clinical Isolates of Mycobacterium tuberculosis [PDF]
Scientia Pharmaceutica, 2018 In clinical isolates of Mycobacterium tuberculosis (MTB), resistance to pyrazinamide occurs by mutations in any positions of the pncA gene (NC_000962.3) especially in nucleotides 359 and 374.
Manijeh Kahbazi +6 more
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Pyrazinamide Resistance and pncA Mutation Profiles in Multidrug Resistant Mycobacterium Tuberculosis
Infection and Drug Resistance, 2022 Dawei Shi,1,* Qiulong Zhou,2,* Sihong Xu,1 Yumei Zhu,3 Hui Li,4 Ye Xu2 1National Institutes for Food and Drug Control, Institute of Pathogen Biology at the Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s ...
Shi D, Zhou Q, Xu S, Zhu Y, Li H, Xu Y
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BMC Infectious Diseases, 2017 Background The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies.
Sarah Sengstake +8 more
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Structure guided prediction of Pyrazinamide resistance mutations in pncA [PDF]
Scientific Reports, 2020 AbstractPyrazinamide plays an important role in tuberculosis treatment; however, its use is complicated by side-effects and challenges with reliable drug susceptibility testing. Resistance to pyrazinamide is largely driven by mutations in pyrazinamidase (pncA), responsible for drug activation, but genetic heterogeneity has hindered development of a ...
Karmakar, Malancha +4 more
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pncAMutations in the Specimens from Extrapulmonary Tuberculosis [PDF]
Tuberculosis and Respiratory Diseases, 2012 Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was noted between the loss of PZase activity and PZA resistance.
Jaechun Lee +7 more
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Microorganisms, 2022 The intestinal microbiota metabolic activity towards the available substrates generates myriad bacterial metabolites that may accumulate in the luminal fluid. Among them, indole and indole-related compounds are produced by specific bacterial species from
Naouel Tennoune +2 more
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