Results 31 to 40 of about 2,990 (173)

Caecal digestibility as an approximation of ileal protein digestibility evaluation in rats

Journal of Nutritional Science, 2023
The rat model can be used to assess ileal protein digestibility rapidly and in first intention, but no standardised method exists. Our objective was to compare methods to assess protein digestibility, depending on collection site (ileum/caecum) and use ...
Florence M. Guillin, Claire Gaudichon, Laetitia Guérin-Deremaux, Catherine Lefranc-Millot, Nadezda Khodorova, Stéphane Besançon, Juliane Calvez   +6 more
doaj   +1 more source

Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed
Pontus, Juréen, Jim, Werngren, Juan-Carlos, Toro, Sven, Hoffner   +3 more
openaire   +2 more sources

Colorimetric methods for rapid determination of pyrazinamide resistance

International Journal of Mycobacteriology, 2020
Background: Because pyrazinamide (PZA) is only effective for Mycobacterium tuberculosis at an acidic pH, susceptibility tests are more difficult to perform than those for other anti-tuberculosis (TB) drugs.
Ahmet Ugur Akbal, Belma Durupinar, Ahmet Yilmaz Coban   +2 more
doaj   +1 more source

Combining Plant Proteins to Achieve Amino Acid Profiles Adapted to Various Nutritional Objectives—An Exploratory Analysis Using Linear Programming

Frontiers in Nutrition, 2022
Although plant proteins are often considered to have less nutritional quality because of their suboptimal amino acid (AA) content, the wide variety of their sources, both conventional and emerging, suggests potential opportunities from complementarity ...
Laurianne Dimina, Laurianne Dimina, Didier Rémond, Jean-François Huneau, François Mariotti   +4 more
doaj   +1 more source

Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA [PDF]

Antimicrobial Agents and Chemotherapy, 1996
Pyrazinamide (PZA) is one of the three most important drugs for treatment of Mycobacterium tuberculosis infections. The antibacterial activity of PZA requires a bacterial enzyme, pyrazinamidase (PZAase), which hydrolyzes PZA to form pyrazinoic acid and ammonia. Most PZA-resistant clinical M. tuberculosis isolates lack PZAase activity.
R, Frothingham, W A, Meeker-O'Connell, E A, Talbot, J W, George, K N, Kreuzer   +4 more
openaire   +2 more sources

Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance [PDF]

Frontiers in Molecular Biosciences, 2020
Une approche centrale pour mieux comprendre les forces impliquées dans le maintien des structures protéiques consiste à étudier le repliement des protéines et les propriétés thermodynamiques. L'effet du processus de pliage est souvent perturbé dans les états mutés.
Muhammad Tahir Khan, Sajid Ali, Muhammad Tariq Zeb, Aman Chandra Kaushik, Shaukat Iqbal Malik, Dong-Qing Wei, Dong-Qing Wei   +6 more
openaire   +3 more sources

Mechanisms of Antibiotic Resistance and Novel Therapeutic Approaches for <i>Mycobacterium tuberculosis</i>: A Narrative Review With a Focus on Tuberculosis Mutations in Iran. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), is a highly contagious disease and one of the leading causes of mortality globally. The emergence and dissemination of multidrug‐resistant (MDR) strains of M. tuberculosis have become a major concern, especially in developing countries.
Bodaghi AB, Shariati A, Shamseddin J, Bodaghi AB, Rezaei M, Farahani A.   +5 more
europepmc   +2 more sources

Mycobacterium smegmatis Has Two Pyrazinamidase Enzymes, PncA and PzaA [PDF]

Journal of Bacteriology, 2000
ABSTRACT The Mycobacterium smegmatis pncA gene, encoding nicotinamidase/pyrazinamidase, was identified. While it was similar to counterparts from other mycobacteria, the M. smegmatis PncA had little homology to the other M.
M, Guo, Z, Sun, Y, Zhang
openaire   +2 more sources

Grain boundaries contribute to highly efficient lithium‐ion transport in advanced LiNi0.8Co0.15Al0.05O2 secondary sphere with compact structure

SusMat, 2021
LiNi0.8Co0.15Al0.05O2 (NCA) secondary particles with high tap density have a great potential for high volumetric energy density lithium (Li)‐ion power battery.
Cheng Liu, Heyi Xia, Yinping Wei, Jiabin Ma, Lin Gan, Feiyu Kang, Yan‐Bing He   +6 more
doaj   +1 more source

A pncA polymorphism to differentiate between Mycobacterium bovis and Mycobacterium tuberculosis

Molecular and Cellular Probes, 2004
The pyrazinamidase gene coding for the enzyme that activates the bactericidal drug pyrazinamide contains a polymorphic site that is preserved in Mycobacterium bovis. We synthesized two sets of primers, one encompassing a 180 bp fragment, and the second spanning a 726 bp fragment including the full pncA gene.
A S, Barouni, C J, Augusto, M T P, Lopes, M S, Zanini, C E, Salas   +4 more
openaire   +2 more sources