Results 51 to 60 of about 2,990 (173)

Reimagining the “Well” (Digitally) Literate Body: Lessons From Children's Diverse (Digital)‐Literacies‐in‐the‐Body With Videogames at Home

Reading Research Quarterly, Volume 61, Issue 2, April/May/June 2026.
This graphical abstract provides an overview of the study's context, approach, key findings and implications. This ecoculturally informed study examined children's digital play and well‐being in relation to broader contexts, routines and practices.
Fiona Scott, Liz Chesworth, Cath Bannister, Daniel Kuria, Shabana Roscoe, Yao Wang   +5 more
wiley   +1 more source

Dietary Studies, Guidelines and Recommendations: Limited Nutrient Deficiency Risks and Significant Modelled Health Benefits in French Adults Following a More Plant-Based Diet

Proceedings
There is a current trend towards plant-based diets in Western countries. These diets have been associated with long-term health benefits but could limit the adequacy of some indispensable nutrients.
Pauline Mombert, Jean-François Huneau, Juhui Wang, Jeanne-Marie Membré, François Mariotti   +4 more
doaj   +1 more source

Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Acetyl‐phosphate–dependent acetylation of E. coli isocitrate lyase (ICL) at K13 and K308 inhibits its activity, while CobB‐mediated deacetylation restores function. Introducing K13R/K308R mutations enhances metabolic balance and increases lycopene yield by 61%, providing a promising approach to optimise microbial cell factories through natural ...
Adrián Martínez‐Vivancos, Beatriz Gomariz‐Turpin, Gema Lozano‐Terol, Rosa Alba Sola‐Martínez, Álvaro Ortega, Julia Gallego‐Jara, Teresa de Diego Puente   +6 more
wiley   +1 more source

Rapid Sequencing of the Mycobacterium tuberculosis pncA Gene for Detection of Pyrazinamide Susceptibility [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACT We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and 100%, respectively, compared to those of MGIT drug susceptibility testing, after the exclusion of synonymous ...
Streicher, Elizabeth M., Maharaj, Kashmeel, York, Talita, Van Heerden, Carel, Barnard, Marinus, Diacon, Andreas, Mendel, Carl M., Bosman, Marlein E., Hepple, Juli A., Pym, Alexander S., Warren, Robin M., Van Helden, Paul D.   +11 more
openaire   +3 more sources

Functional validation of

Journal of Global Antimicrobial Resistance
Objectives: Pyrazinamide (PZA) resistance is attributed to mutations in pncA and complete functional evidence is lacking. We aimed to functionally assess mutations in pncA and its upstream regulatory region (URR) in clinical isolates.
Najeeb Ullah, Xiaoman Zheng, Jing Gu, Ji-Fang Yu, Jiao-Yu Deng, Yaokai Chen   +5 more
doaj   +1 more source

Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts)

Neurogastroenterology &Motility, Volume 38, Issue 4, April 2026.
Anesthesia can alter measurements during digestive endoscopies, yet no standardized protocol currently exists. Two expert groups—the French Neuro‐Gastroenterology Group (GFNG) and anesthesiologists—used the Delphi method to reach a consensus on which drugs have an influence (91 amendments), ultimately resulting in a proposed anesthesia protocol (28 ...
Domitille Renard, Thomas Clavier, Osama Abou‐Arab, Gérard Amarenco, Emmanuel Besnier, Alice Blet, Matthieu Boisson, Charlène Brochard, Benoit Coffin, Audrey De Jong, Denis Frasca, Marc Garnier, Aurelie Gouel, Jérémie Jacques, Arthur James, Yoann Launey, Anne‐Marie Leroi, Chloé Melchior, Daphné Michelet, François Mion, Maxime Nguyen, Emmanuel Rineau, Amélie Rollé, Sabine Roman, Stéphanie Sigaut, Heithem Soliman, Fabien Wuestenberghs, Frank Zerbib, Guillaume Gourcerol, Charlotte Desprez   +29 more
wiley   +1 more source

Pyrazinamide Resistance and Mutation Patterns Among Multidrug-Resistant Mycobacterium tuberculosis from Henan Province

Infection and Drug Resistance, 2020
Jie Shi, Ruyue Su, Danwei Zheng, Yankun Zhu, Xiaoguang Ma, Shaohua Wang, Hui Li, Dingyong Sun Henan Province Center for Disease Control and Prevention, Zhengzhou, Henan Province, People’s Republic of ChinaCorrespondence: Jie Shi; Dingyong Sun Tel ...
Shi J, Su R, Zheng D, Zhu Y, Ma X, Wang S, Li H, Sun D   +7 more
doaj  

Proteomic insights into the invasiveness and tumor progression of non‐functioning pituitary adenomas: A scoping review

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choice; however, residual tumor tissue is frequently observed, with between 30% and 50% of these cases ...
Thomas Skoglund, Linus Köster, Annika Thorsell, Oskar Ragnarsson, Gudmundur Johannsson, Tobias Hallén   +5 more
wiley   +1 more source

Non- pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That? [PDF]

Journal of Clinical Microbiology, 2017
ABSTRACT Pyrazinamide (PZA) is a key component for the effective treatment of drug-susceptible and PZA-susceptible multidrug-resistant (MDR PZA-S ) tuberculosis (TB). pncA gene mutations are usually detected in a clear majority (>90%) of PZA-resistant strains but obviously not in
Jim, Werngren, Erik, Alm, Mikael, Mansjö   +2 more
openaire   +2 more sources

Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan

BMC Infectious Diseases, 2019
Background Pyrazinamide (PZA) is an important component of first-line drugs because of its distinctive capability to kill subpopulations of persistent Mycobacterium tuberculosis (MTB).
Muhammad Tahir khan, Shaukat Iqbal Malik, Sajid Ali, Nayyer Masood, Tariq Nadeem, Anwar Sheed Khan, Muhammad Tanvir Afzal   +6 more
doaj   +1 more source