Results 51 to 60 of about 5,852 (197)

Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China

Infection and Drug Resistance, 2021
Shufang Lin,1 Shuzhen Wei,1 Yong Zhao,1 Zhisong Dai,1 Jian Lin,1 Yu Pang2 1Fujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and Prevention, Fuzhou, People’s Republic of China; 2Department of Bacteriology and ...
Lin S, Wei S, Zhao Y, Dai Z, Lin J, Pang Y   +5 more
doaj  

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Rapid Sequencing of the Mycobacterium tuberculosis pncA Gene for Detection of Pyrazinamide Susceptibility [PDF]

Journal of Clinical Microbiology, 2014
ABSTRACT We developed a pyrazinamidase gene DNA-sequencing method to rapidly identify pyrazinamide resistance-causing mutations in GenoLyse-treated, smear-positive sputum specimens. The sensitivity and specificity were 90.9 and 100%, respectively, compared to those of MGIT drug susceptibility testing, after the exclusion of synonymous ...
Streicher, Elizabeth M., Maharaj, Kashmeel, York, Talita, Van Heerden, Carel, Barnard, Marinus, Diacon, Andreas, Mendel, Carl M., Bosman, Marlein E., Hepple, Juli A., Pym, Alexander S., Warren, Robin M., Van Helden, Paul D.   +11 more
openaire   +3 more sources

Mycobacterium tuberculosis Pyrazinamide Resistance Determinants: a Multicenter Study

mBio, 2014
Pyrazinamide (PZA) is a prodrug that is converted to pyrazinoic acid by the enzyme pyrazinamidase, encoded by the pncA gene in Mycobacterium tuberculosis.
Paolo Miotto, Andrea M. Cabibbe, Silke Feuerriegel, Nicola Casali, Francis Drobniewski, Yulia Rodionova, Daiva Bakonyte, Petras Stakenas, Edita Pimkina, Ewa Augustynowicz-Kopeć, Massimo Degano, Alessandro Ambrosi, Sven Hoffner, Mikael Mansjö, Jim Werngren, Sabine Rüsch-Gerdes, Stefan Niemann, Daniela M. Cirillo   +17 more
doaj   +1 more source

Full‐Length Transcriptome Profiles Reveal the Molecular Function of Oncogene HNRNPA2B1 in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Triple negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer with the worst prognosis. Heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1), a member of the RNA‐binding protein (RBP) hnRNPs family, is aberrantly expressed in various human cancers, serving as a marker of poor prognosis and acting as an oncogene ...
Lina Yi, Yongtao Li, Jianghua Ou
wiley   +1 more source

Reimagining the “Well” (Digitally) Literate Body: Lessons From Children's Diverse (Digital)‐Literacies‐in‐the‐Body With Videogames at Home

Reading Research Quarterly, Volume 61, Issue 2, April/May/June 2026.
This graphical abstract provides an overview of the study's context, approach, key findings and implications. This ecoculturally informed study examined children's digital play and well‐being in relation to broader contexts, routines and practices.
Fiona Scott, Liz Chesworth, Cath Bannister, Daniel Kuria, Shabana Roscoe, Yao Wang   +5 more
wiley   +1 more source

Actividades Interinstitucionales - 1985 [PDF]

, 1986
102 Páginas.La presente publicación relaciona las principales actividades de carácter interinstitucional para 1985. Los contenidos de estas actividades constituyen fundamentalmente guías docentes ya que es tradición en el ...
Instituto Interamericano de Cooperación para la Agricultura (IICA), Programa Nacional de Capacitación Agropecuaria (PNCA)   +1 more
core  

Dynamic Lysine Acetylation Disrupts Isocitrate Lyase Function and Enables Metabolic Optimisation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Acetyl‐phosphate–dependent acetylation of E. coli isocitrate lyase (ICL) at K13 and K308 inhibits its activity, while CobB‐mediated deacetylation restores function. Introducing K13R/K308R mutations enhances metabolic balance and increases lycopene yield by 61%, providing a promising approach to optimise microbial cell factories through natural ...
Adrián Martínez‐Vivancos, Beatriz Gomariz‐Turpin, Gema Lozano‐Terol, Rosa Alba Sola‐Martínez, Álvaro Ortega, Julia Gallego‐Jara, Teresa de Diego Puente   +6 more
wiley   +1 more source

Informe de evaluación Programa Nacional de Capacitación Agropecuaria - PNCA. Anexos [PDF]

, 1988
96 páginas pdf.Contiene la lista de anexos correspondiente al Informe de Evaluación del Programa Nacional de Capacitación Agropecuaria (PNCA) establecido entre el Gobierno de Colombia y el IICA.
Instituto Interamericano de Cooperación para la Agricultura (IICA), Programa Nacional de Capacitación Agropecuaria (PNCA) (Colombia).   +1 more
core  

A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings. [PDF]

PLoS ONE, 2016
In South Africa and other high prevalence countries, transmission is a significant contributor to rising rates of multidrug resistant tuberculosis (MDR-TB). Thus, there is a need to develop an early detection system for transmission clusters suitable for
Halima M Said, Nicole Kushner, Shaheed V Omar, Andries W Dreyer, Hendrik Koornhof, Linda Erasmus, Yasmin Gardee, Ivy Rukasha, Elena Shashkina, Natalie Beylis, Gilla Kaplan, Dorothy Fallows, Nazir A Ismail   +12 more
doaj   +1 more source