Results 71 to 80 of about 2,990 (173)

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China

BMC Infectious Diseases, 2020
Background Pyrazinamide still may be a useful drug for treatment of rifampin-resistant (RR-TB) or multidrug-resistant tuberculosis (MDR-TB) in China while awaiting scale up of new drugs and regimens including bedaquiline and linezolid.
Hui Xia, Susan van den Hof, Frank Cobelens, Yang Zhou, Bing Zhao, Shengfen Wang, Yanlin Zhao   +6 more
doaj   +1 more source

pncA gene mutations in reporting pyrazinamide resistance among the MDR-TB suspects

Infection, Genetics and Evolution, 2019
Mutations in pncA gene contributing to PZA resistance was not clearly elucidated in China. To reveal the correlated mutations of pncA gene on pyrazinamide (PZA) resistance. 148 Mycobacterium tuberculosis clinical isolates were included from multi-drug resistant tuberculosis suspects.
Xiaoyuan Wu, Wei Lu, Yan Shao, Honghuan Song, Guoli Li, Yan Li, Limei Zhu, Cheng Chen   +7 more
openaire   +2 more sources

Potential unexpected effects of meat reduction in diet: Could educational attainment influence meat substitution strategies?

Agricultural and Food Economics
Regulation of meat consumption appears to be a relevant public policy to limit diet-related greenhouse gas emissions. However, the real impact of such a policy (e.g., tax) on human health and nutrition remains uncertain, especially for underprivileged ...
Pierre Levasseur, François Mariotti, Isabelle Denis, Olga Davidenko   +3 more
doaj   +1 more source

Exploring of pyrazinamidase recombinant activity from PZA-sensitive and resistant Mycobacterium tuberculosis expressed in Escherichia coli BL21 (DE3) [PDF]

Brazilian Journal of Biology
The mutations of pncA gene encoding pyrazinamidase/PZase in Mycobacterium tuberculosis are often associated with pyrazinamide/PZA resistance. The H and R1 isolates showed significant phenotypic differences to PZA.
P. Purkan, S. Hadi, W. Retnowati, S. Sumarsih, D. K. Wahyuni, B. Piluharto, T. M. Panjaitan, C. Ifada, A. Nadila, B. A. Nabilah   +9 more
doaj   +1 more source

Investigating the Mechanism of Antimycobacterial and Antiproliferative Activity of (E)‐N’‐Benzylidenepyrazine‐2‐Carbohydrazides and their Derivatives

ChemMedChem, Volume 20, Issue 18, September 25, 2025.
(E)‐N’‐benzylidenepyrazine‐2‐carbohydrazides with 2‐OH, 2,3‐diOH or 2,4‐diOH substitution exhibit good antimycobacterial or antiproliferative activity, and iron chelation similar to salicylaldehyde isonicotinoyl hydrazone (SIH). A series of 33 (E)‐N’‐benzylidenepyrazine‐2‐carbohydrazides and their derivatives were synthesized and tested for biological ...
Priam‐Amedeo Houngbedji, Daria Elżbieta Nawrot, Ondřej Janďourek, Klára Konečná, Martin Novák, Pavla Paterová, Pavel Bárta, Martina Hrast Rambaher, Eva Novotná, Carlo Castellano, Matteo Mori, Fiorella Meneghetti, Monika Záhorszká, Jana Korduláková, Jan Zitko   +14 more
wiley   +1 more source

Estandarización de una Técnica de Complementación del Gen pncA en Mycobacterium tuberculosis pncA-knockout: Herramienta Para el Estudio de la Relación Entre Mutaciones en pncA y Parámetros Fenotípicos

, 2022
2019-09 ...
Cauna Orocollo, Yudith, Sheen Cortavarría, Patricia, Zimic Peralta, Mirko   +2 more
openaire   +1 more source

Detection of Pyrazinamide-Resistant Mycobacteriumtuberculosis by PCR-SSCP of pncA Gene

Tuberculosis and Respiratory Diseases, 1998
Background : Recently the incidence of tuberculosis is increasing in many countries and control of the disease is further threatened by the emergence of multi-drug resistant tuberculosis. So rapid detection of drug resistance is very important. Pyrazinamide (PZA) is a first-line chemotherapeutic agent for tuberculosis.
Tae Sun Shim, Young Whan Kim, Jae Yong Chin, Chae Man Lim, Sang Do Lee, Younsuck Koh, Woo Sung Kim, Dong Soon Kim, Won Dong Kim   +8 more
openaire   +1 more source

Event and elevation

Inscriptions, 2022
What is it like, the event in which we become ourselves? What is its relationship to other kinds of event? And where might the event happen? When people say today that they “stand with” or that they are “allies,” they are challenging hierarchical notions
David Ritchie
doaj  

Effects of alimentary-derived bacterial metabolites on energy metabolism in colonic epithelial cells and inflammatory bowel diseases

Exploration of Medicine
In this review, we present the main luminal fuels that are responsible for energy production in colonocytes, namely the bacterial metabolites short-chain fatty acids and lactate, which are produced from undigestible polysaccharides and proteins, and ...
Mireille Andriamihaja, François Blachier   +1 more
doaj   +1 more source