Results 61 to 70 of about 2,990 (173)
Health Services Research, Volume 61, Issue 1, February 2026.ABSTRACTObjectiveTo develop and validate a hierarchical algorithm for assigning prenatal care (PNC) encounters using claims data while ensuring continuity of care.Study Setting and DesignWe conducted a retrospective cohort study among South Carolina Medicaid beneficiaries.
Songyuan Deng +2 more
wiley +1 more source
Direct Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis by Use of pncA PCR Sequencing [PDF]
Journal of Clinical Microbiology, 2019 An in-house-developed pncA sequencing assay for analysis of pyrazinamide (PZA) resistance was evaluated using 162 archived Mycobacterium tuberculosis complex (MTBC) isolates with phenotypic PZA susceptibility profiles that were well defined by analysis of Bactec MGIT 960 PZA kit and PZase ...
Kingsley King-Gee Tam +7 more
openaire +2 more sources
Rapid colorimetric testing for pyrazinamide susceptibility of M. tuberculosis by a PCR-based in-vitro synthesized pyrazinamidase method. [PDF]
PLoS ONE, 2011 Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug. But PZA susceptibility test is challenging because PZA activity is optimal only in an acid environment that inhibits the growth of M. tuberculosis.
Man Zhou +9 more
doaj +1 more source
Advanced Science, Volume 13, Issue 3, 14 January 2026.This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss +9 more
wiley +1 more source
Characterization of pncA Mutations in Pyrazinamide-Resistant Mycobacterium tuberculosis in Brazil [PDF]
Antimicrobial Agents and Chemotherapy, 2005 ABSTRACT In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was ...
Vívian de F Sumnienski, Rodrigues +5 more
openaire +3 more sources
International Journal of Microbiology, Volume 2026, Issue 1, 2026.Objectives Rapid identification of drug‐resistant tuberculosis remains critical for the initiation of appropriate treatment regimens, improved success rates and reduction in the development of drug resistance. In this study, we compared the diagnostic performance of two novel diagnostic tests, Xpert MTB/XDR and Deeplex Myc‐TB (both CE marked).
Mirae Park +5 more
wiley +1 more source
Detection of Pyrazinamide Resisitance in Mycobacterium Tuberculosis by Sequencing of pncA Gene
Tuberculosis and Respiratory Diseases, 2001 Background : Examining the biological susceptibility of Mycobacterium tuberculosis to pyrazinamide (PZA) in vitro is very difficult as PZA is inactive under normal culture conditions. The biological susceptibility test, an enzyme assay for Pzase activity, and a genetic test for pncA gene mutations, were performed in order to predict PZA resistance ...
Jee Yoon Hwang +9 more
openaire +1 more source
Combating Drug‐Resistant Tuberculosis: Advancements in Diagnostics and Therapeutics
Pulmonary Medicine, Volume 2026, Issue 1, 2026.The increasing prevalence of multidrug‐resistant (MDR) and extensively drug‐resistant (XDR)Mycobacterium tuberculosis has emerged as a major global health concern. Advanced molecular diagnostics, including rapid assays, have improved resistance detection; however, resource‐limited settings remain underserved. Nanotechnology‐based drug delivery systems,
Silvi Gautam +5 more
wiley +1 more source
Characterization ofpncAMutations of Pyrazinamide-ResistantMycobacterium tuberculosisin Korea [PDF]
Journal of Korean Medical Science, 2001 Pyrazinamide (PZA) is one of the most important drugs for the treatment of Mycobacterium tuberculosis infection. However, the increasing frequency of PZA-resistant strains limits its effectiveness. In Korea, most PZA-resistant strains also exhibit both isoniazid and rifampin resistance making it essential to identify these resistant strains accurately ...
K W, Lee, J M, Lee, K S, Jung
openaire +2 more sources
VIEW, Volume 6, Issue 6, December 2025.Despite efficacious antiretroviral therapy, 10%–40% of HIV‐infected individuals exhibit inadequate immune reconstitution due to persistent inflammatory activation and NAD+ metabolic dysregulation—a critical cofactor in cellular bioenergetics. We administered silibinin to 53 HIV immunological non‐responders and elucidated its mechanism through selective
Wenli Liu +13 more
wiley +1 more source