Results 41 to 50 of about 25,215 (206)

Xanthine oxidase inhibition by allopurinol increases in vitro pyrazinamide-induced hepatotoxicity in HepG2 cells. [PDF]

, 2010
Contains fulltext : 87446.pdf (Publisher’s version ) (Open Access)Despite the important role of pyrazinamide in tuberculosis treatment, little is known about the mechanism of pyrazinamide-induced hepatotoxicity.
Alma Tostmann, Boeree, M.J., Rob E. Aarnoutse, P.N. Richard Richard, Richard, P.N., Martin J. Boeree, Tostmann, A., Aarnoutse, R.E., Wilbert H.M. Peters, Peters, W.H.M.   +9 more
core   +1 more source

Comparative performance of genomic methods for the detection of pyrazinamide resistance and heteroresistance in Mycobacterium tuberculosis [PDF]

, 2021
: Pyrazinamide is an important component of both drug-susceptible and drug-resistant tuberculosis treatment regimens. Although approximately 50% of rifampin-resistant isolates are also resistant to pyrazinamide, pyrazinamide susceptibility testing is not
Engelthaler, David, Metcalfe, John, Heupink, Tim H., Limberis, Jason, Whitfield, Michael G., Warren, Robin, Van Rie, Annelies, Metcalfe, John Z., Folkerts, Megan, Whitfield, Michael, Allender, Christopher, Heupink, Tim, Engelthaler, David M., Warren, Robin M.   +13 more
core   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

Evolutionary Genetic Analysis of the Pyrazinamidase Gene in Seven Global Populations of Mycobacterium tuberculosis

International Journal of Mycobacteriology
Background: This study aims to identify the signatures of natural selection in the pyrazinamidase (pncA) gene to see if genetic adaptations by Darwinian natural selection have shaped genetic composition of Mycobacterium tuberculosis (Mtb).
Neha Kumari, Nikhat Khan, Aparup Das
doaj   +1 more source

Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?

, 2005
Introduction: It is perceived wisdom that within the host macrophage, Mycobacterium tuberculosis frequently encounters oxidative stress. Exposure of bacteria to reactive oxygen intermediates can have a mutagenic effect on the DNA.
O'Sullivan, DM, O'Sullivan, D M, McHugh, TD, Timothy D. McHugh, O'Sullivan, Denise M, Gillespie, S H, Gillespie, Stephen H, Gillespie, SH, Stephen H. Gillespie, McHugh, Timothy D, Denise M. O'Sullivan, McHugh, T D   +11 more
core   +1 more source

Comparative Clinical Efficacy and Safety of Multi‐Segment Thoracolumbar Tuberculosis Treated Through the Posterior “Detour Method” Versus the Combined Anterior–Posterior Approach: A Technique Note and Preliminary Retrospective Study

Orthopaedic Surgery, Volume 18, Issue 7, Page 1508-1517, July 2026.
A simple schematic diagram; the red dashed arrow indicates the direction of surgical decompression. ABSTRACT Objective With the progress of spinal tuberculosis treatment theory and surgical tools, how to further improve the surgical efficacy, reduce surgical trauma, and increase safety in multi‐segmental spinal tuberculosis is still controversial ...
Dian Zhong, Wei Zeng, Guosheng Zhao, Yu Du, Yang Wang, Zhenyong Ke   +5 more
wiley   +1 more source

Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment [PDF]

, 2004
Severe liver injury has been attributed to preventive treatment of latent tuberculosis infection with a 2-month course of rifampin-pyrazinamide. A retrospective cohort study in The Netherlands compared the hepatotoxicity of preventive treatment with ...
Kik, S., Mensen, Marlies, Cobelens, Frank, van Gerven, Paul, Keizer, S., Cobelens, F.G.J., van Hest, Rob, Kalisvaart, Nico, Keizer, Sytze, Trompenaars, Marie-Christine, van Gerven, P., Mensen, M.E.A., Borgdorff, M.W., Kik, Sandra, Borgdorff, Martien, Baars, H., Kalisvaart, N., van Hest, E., Trompenaars, M-C., Baars, Hennie   +19 more
core   +1 more source

Female Genital Tuberculosis, Ghana: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Female genital tuberculosis is an underdiagnosed cause of infertility and amenorrhea in tuberculosis‐endemic regions. Hysteroscopy combined with histopathology can confirm the diagnosis even when molecular testing is negative. Clinicians should maintain a high index of suspicion and pursue multimodal diagnostic evaluation in women with ...
Anthony K. Dah, Dennis Brempong, Paschal K. Dah, Gladys Kaba, Emily Boakye‐Yiadom, Ernest Kwasi Adjei, Verner N. Orish   +6 more
wiley   +1 more source

Role of Nigella Sativa Seeds on Pyrazinamide Induced Hepatotoxicity

Journal of Islamic International Medical College, 2019
Objective: To determine the hepatoprotective effect of Nigella sativa seeds in Pyrazinamide induced hepatic damage in albino mice. Study Design: An experimental study.
Amtul Hafeez , Akbar Waheed , Neelofar Yousaf
doaj  

Contezolid in the Treatment of Multidrug‐Resistant Tuberculous Meningitis: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Na Wang, Xingyu Li, Qiaoyi Yan, Haitao Su, Yufeng Liu, Yanhong Li, Chunrong Yang, Yingchun Gu, Taoli Yan, Qiuzhen Wang, Xia Liu   +10 more
wiley   +1 more source