Results 1 to 10 of about 25,028 (165)

Neuro-ophthalmic complications of tuberculosis and its treatment: a systematic review and meta-analysis [PDF]

Frontiers in Ophthalmology
IntroductionTuberculosis (TB) and its treatment have been associated with significant neuro-ophthalmic morbidity; however, the magnitude and determinants of these complications remain incompletely characterized.
Ahmed A. Alessa, Ahmed Zuhier Awan, Abdulkarim B. Almutairi, Ibrahim Ghassan Ajabnoor, Mohammed Marouf M. Jan, Ahmed Y. Azzam, Ahmed Y. Azzam, Nooran Badeeb, Nooran Badeeb   +8 more
doaj   +2 more sources

Incidence and prognostic factor of ethambutol‐related optic neuropathy: 10‐year experience in southern Taiwan

Kaohsiung Journal of Medical Sciences, 2015
To investigate the incidence and prognostic factors of ethambutol-related optic neuropathy (EON) in one medical center of southern Taiwan, a retrospective chart review study with 4803 newly diagnosed tuberculosis cases from January 2002 to July 2011 at ...
Shih-Chou Chen, Muh-Chiou Lin, Shwu-Jiuan Sheu   +2 more
exaly   +3 more sources

Mutations in the ubiA gene are the major mechanism of ethambutol resistance in Mycobacterium avium [PDF]

Microbiology Spectrum
Mycobacterium avium-intracellulare complex (MAC) infections are the most common nontuberculous mycobacterial infections, and ethambutol (EMB) is one of the main therapeutic agents used to treat MAC infections.
Yuwei Qiu, Xu Dong, Dan Cao, Xiuzhi Jiang, Zhongkang Ji, Pusheng Xu, Yi Li, Kaijing Xu, Ying Zhang   +8 more
doaj   +2 more sources

Adverse Drug Reactions to a Daily Fixed-dose Combination Based Antituberculosis Treatment Regime in India’s National Tuberculosis Elimination Programme: A Prospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: In India, the daily weight-based, Fixed Dose Combination (FDC) Antituberculosis Treatment (ATT) regime under the National Tuberculosis Elimination Programme (NTEP) was introduced, replacing the previous intermittent regime with the ...
Kapil Mate, Gyanshankar Mishra, Radha Munje   +2 more
doaj   +1 more source

Risk Factors of Optic Neuropathy in Ethambutol Users: Interaction with Isoniazid and Other Associated Conditions of Toxic Optic Neuropathy

Toxics
(1) Background: To investigate the risk factors associated with optic neuropathy (ON) and validate the hypothesis that concomitant isoniazid use and other causes of toxic ON affect the development of ON in ethambutol users. (2) Methods: This cohort study
Seong Joon Ahn, Jiyeong Kim, Kim Jiyeong   +2 more
exaly   +3 more sources

Ethambutol toxicity: Expert panel consensus for the primary prevention, diagnosis and management of ethambutol-induced optic neuropathy

Indian Journal of Ophthalmology, 2021
Ethambutol use may lead to permanent vision loss by inducing a dose- and duration-dependent optic neuropathy. This has been of concern to ophthalmologists and physicians both; however, ethambutol continues to be used because of its anti-mycobacterial ...
Rohit Saxena, Digvijay Singh, Swati Phuljhele, V Kalaiselvan, Satya Karna, Rashmin Gandhi, Anupam Prakash, Rakesh Lodha, Anant Mohan, Vimla Menon, Rajeev Garg   +10 more
doaj   +1 more source

The first-line antituberculosis drugs, and their fixed-dose combination induced abnormal sperm morphology and histological lesions in the testicular cells of male mice

Frontiers in Cell and Developmental Biology, 2022
Rifampicin (RIF), Isoniazid (INH), Ethambutol (EMB), Pyrazinamide (PZA), and/or their fixed-dose combination (FDC) are extensively prescribed in the cure of Tuberculosis (TB) globally.
Adekunle A. Bakare, Victoria Y. Moses, Charles T. Beckely, Toluwani I. Oluyemi, Gift O. Ogunfeitimi, Aduragbemi A. Adelaja, Glory T. Ayorinde, Adeyinka M. Gbadebo, Olukunle S. Fagbenro, Olusegun I. Ogunsuyi, Opeoluwa M. Ogunsuyi, Olusoji Mayowa Ige   +11 more
doaj   +1 more source

Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis

Tropical Medicine and Infectious Disease, 2023
Background: Patients with tuberculosis (TB) may develop multi-organ failure and require admission to intensive care. In these cases, the mortality rates are as high as 78% and may be caused by suboptimal serum concentrations of first-line TB drugs.
Francisco Beraldi-Magalhaes, Suzanne L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Amanda Araujo Costa, Mariana Millan Fachi, Marcus Vinicius de Liz, Alexandra Brito de Souza, Izabella Picinin Safe, Roberto Pontarolo, Steven Wallis, Jeffrey Lipman, Jason A. Roberts, Marcelo Cordeiro-Santos   +14 more
doaj   +1 more source

Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line [PDF]

Genetics and Molecular Biology, 2023
Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the most important aspects of tuberculosis, considering that there are emerging resistant strains for almost every known drug used for its treatment.
Nicolas de Oliveira Rossini, Marcio Vinicius Bertacine Dias   +1 more
doaj   +1 more source

Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Ethambutol is considered to be safest first-line antitubercular drug, and patient acceptability is rather good in both intensive and continuation phase of the tuberculosis treatment with daily regimen.
Bijoy Kumar Panda, Medha Bargaje, Vaibhav R Suryawanshi, Sathiyanarayanan Lohidasan   +3 more
doaj   +1 more source