Results 11 to 20 of about 25,093 (162)

Is the Pharmacokinetics of First-Line Anti-TB Drugs a Cause of High Mortality Rates in TB Patients Admitted to the ICU? A Non-Compartmental Pharmacokinetic Analysis

Tropical Medicine and Infectious Disease, 2023
Background: Patients with tuberculosis (TB) may develop multi-organ failure and require admission to intensive care. In these cases, the mortality rates are as high as 78% and may be caused by suboptimal serum concentrations of first-line TB drugs.
Francisco Beraldi-Magalhaes, Suzanne L. Parker, Cristina Sanches, Leandro Sousa Garcia, Brenda Karoline Souza Carvalho, Amanda Araujo Costa, Mariana Millan Fachi, Marcus Vinicius de Liz, Alexandra Brito de Souza, Izabella Picinin Safe, Roberto Pontarolo, Steven Wallis, Jeffrey Lipman, Jason A. Roberts, Marcelo Cordeiro-Santos   +14 more
doaj   +1 more source

Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line [PDF]

Genetics and Molecular Biology, 2023
Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the most important aspects of tuberculosis, considering that there are emerging resistant strains for almost every known drug used for its treatment.
Nicolas de Oliveira Rossini, Marcio Vinicius Bertacine Dias   +1 more
doaj   +1 more source

Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022
Ethambutol is considered to be safest first-line antitubercular drug, and patient acceptability is rather good in both intensive and continuation phase of the tuberculosis treatment with daily regimen.
Bijoy Kumar Panda, Medha Bargaje, Vaibhav R Suryawanshi, Sathiyanarayanan Lohidasan   +3 more
doaj   +1 more source

Evaluation of the Long-term Effect of Ethambutol Usage on the Retinal Nerve Fiber Layer Using Spectral-Domain Optical Coherence Tomography

Beyoglu Eye Journal, 2020
INTRODUCTION[|]The aim of this study was to use spectral-domain optical coherence tomography (SD-OCT) to evaluate the long-term effect of ethambutol on the optic nerve fiber layer.[¤]METHODS[|]Twenty eyes of 10 patients who had been treated with ...
Gul Varan, Leyla Hazar, Ahmet Sahin
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Mitochondrial Mutations in Ethambutol-Induced Optic Neuropathy

Frontiers in Cell and Developmental Biology, 2021
Background: Ethambutol-induced optic neuropathy (EON) is a well-recognized ocular complication in patients who take ethambutol as a tuberculosis treatment. The aim of the current study was to investigate the presence of mitochondrial mutations, including
Xiao-Hui Zhang, Xiao-Hui Zhang, Yue Xie, Quan-Gang Xu, Kai Cao, Ke Xu, Zi-Bing Jin, Yang Li, Shi-Hui Wei   +8 more
doaj   +1 more source

Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst

Frontiers in Microbiology, 2018
Mycobacterial cell wall inhibitors interfere with targets involved in synthesis of mycolic acids, arabinogalactan and peptidoglycan. These antibiotics corrupt structural integrity of the cell envelope and this is believed to be the cause of drug mediated
Annanya Shetty, Thomas Dick, Thomas Dick
doaj   +1 more source

Potentiating the Anti-Tuberculosis Efficacy of Peptide Nucleic Acids through Combinations with Permeabilizing Drugs

Microbiology Spectrum, 2022
The emergence of antimicrobial resistance warrants for the development of improved treatment approaches. In this regard, peptide nucleic acids (PNAs) have shown great promise, exhibiting antibiotic properties through the targeting of cellular nucleic ...
Karishma Berta Cotta, Saptarshi Ghosh, Sarika Mehra   +2 more
doaj   +1 more source

Molecular resistance of Ethambutol in clinical samples obtained from patients admitted to the health center in Ardabil province using MAS-PCR [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز
Background. Global stop TB is a critical strategy which aims at reducing the incidence of tuberculosis to less than one case per one million people by 2050.
Furugh Babazadeh, Jafar Mohammadshahi, Hafez Mirzanejad-Asl, Reyhaneh Rahimzadeh, Zohreh Neyestani, Roghayeh Teimourpour   +5 more
doaj   +1 more source

The Effect of Ethambutol on Optic Nerve by Spectral Domain Optical Coherence Tomography

Namık Kemal Tıp Dergisi, 2020
Aim:To evaluate; the retinal nerve fiber layer difference between healthy control groups and patients who were taking ethambutol medication by using spectral domain optical coherence tomography (SD-OCT) and to evaluate the usage of SD-OCT for early ...
Gül VARAN, Ahmet ŞAHİN
doaj   +1 more source