Results 41 to 50 of about 25,093 (162)

A Systematic Review of Published Physiologically Based Pharmacokinetic Models for Drug Excretion Into Human Breastmilk: Knowledge Gaps and Opportunities to Optimize Reporting and Modeling Practices

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is increasingly used to predict infant exposure to medications via breast milk. Existing guidance on reporting of PBPK modeling analyses is unstructured and nonbinding to researchers. We evaluated reporting practices and modeling approaches in published PBPK modeling studies.
Joshua Kiptoo, Davies Otieno, Kenta Yoshida, Neel Deferm, Aida Nakayiwa Kawuma, Francis Williams Ojara, Adeniyi Olagunju, Jackson K. Mukonzo, Catriona Waitt   +8 more
wiley   +1 more source

Clinical guideline highlights for the hospitalist: Updates on the treatment of drug‐susceptible and drug‐resistant tuberculosis

Journal of Hospital Medicine, EarlyView.
Allison Stickles, Anna Poston‐Blahnik, Elizabeth Schlaudecker, Moises Huaman   +3 more
wiley   +1 more source

Primary Tracheal Rosai‐Dorfman Disease Coexisting With Active Pulmonary Tuberculosis

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of primary tracheal Rosai‐Dorfman disease (RDD) with active pulmonary tuberculosis. Bronchoscopic resection immediately relieved > 90% airway obstruction, and anti‐tuberculosis therapy was given, resulting in no recurrence at one‐year follow‐up. ABSTRACT Rosai‐Dorfman disease (RDD) rarely involves the trachea, and active pulmonary
Shijie Yang, Shaoling Li, Wenwen Sun, Ye Gu, Li Yang   +4 more
wiley   +1 more source

Retinal nerve fiber layer thickness and central macular thickness in patients with ethambutol optic neuropathy: a prospective analysis by optical coherence tomography

Delta Journal of Ophthalmology
Background Ethambutol, a key drug for tuberculosis (TB) treatment, poses a risk of ethambutol optic neuropathy, that potentially leads to irreversible visual loss. Early detection is crucial to prevent long-term impairment.
Sri Vidya Kambella, Leelavathamma Thammali, SreeLakshmi Pallamreddy, Prasanna Bharathi   +3 more
doaj   +1 more source

Vegetating Lupus Vulgaris in a Child

JEADV Clinical Practice, EarlyView.
Viktor Pushkarenko, Yana‐Karina Zovdun, Olga Pushkarenko   +2 more
wiley   +1 more source

Applying a Pharmacometrics‐Enabled Machine Learning Analysis to Predict 2‐Month Culture Conversion Using Phase 2a Data in a Tuberculosis Clinical Trial

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
A workflow for appying pharmacometrics‐enable machine learning analysis to predict 2‐month culture conversion using phase 2a data. ABSTRACT Phase 2a trials in tuberculosis patients traditionally assess early bactericidal activity over two weeks, often using the time‐to‐positivity biomarker, followed by a phase 2b study typically lasting 8‐week with ...
Huifang You, Ulrika S. H. Simonsson
wiley   +1 more source

A Painful Purpuric Rash in a Febrile Smoker

JEADV Clinical Practice, EarlyView.
Eugerta Dilka, Ina Sotiri, Irda Rrugeja, Monika Fida   +3 more
wiley   +1 more source

Comparison of the Efficacy and Prognosis of Different Treatment Strategies for Spinal Tuberculosis Patients Undergoing Vertebral Augmentation Surgery by Mistake

Orthopaedic Surgery, Volume 18, Issue 8, Page 1631-1640, August 2026.
Based on the clinical characteristics of patients with spinal tuberculosis after percutaneous vertebral augmentation, the corresponding diagnosis and treatment strategies were explored, and clinical data for the differential diagnosis of spinal tuberculosis were provided.
Xiong Xu, Yatao Wang, Litao Li, Zhanpeng Luo, Ning Liu, Yunfeng Wu, Cunshuo Wang, Bo Wang, Enning Cui, Long Yu, Xu Cui   +10 more
wiley   +1 more source

Cutaneous Mycobacterium haemophilum Infection in an Immunosuppressed Host: A Case Report of Diagnostic Considerations and Microbiologic Confirmation

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Cutaneous Mycobacterium haemophilum infection may be missed due to its requirement for iron supplementation and low‐temperature incubation, making early consideration of NTM infection and use of molecular diagnostics essential, particularly in immunocompromised hosts where IRIS may mimic disease progression.
Angus Lane, Amanda Godbolt, Sarah Morton, Heather Wiseby, Vivek Menon, Chris Coulter, Sushil Pandey, Andrew Burke   +7 more
wiley   +1 more source

Coexisting Pyogenic and Tuberculous Liver Abscess in Uncontrolled Diabetes: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Hepatic tuberculosis can mimic pyogenic liver abscess, particularly in patients with uncontrolled diabetes. Persistent or atypical hepatic lesions unresponsive to antibiotics should prompt tissue diagnosis using histopathology and molecular assays like GeneXpert to ensure timely diagnosis and appropriate management.
Hamna Mehfooz, Azba Israr, Syed Hassan Tanvir Ramzi, Akram Malik, Syed Muhammad Salman Hassan, Sarim Hassan Shahab, Fazal Habib   +6 more
wiley   +1 more source