Results 31 to 40 of about 25,028 (165)

Development of Co-Amorphous Systems for Inhalation Therapy—Part 2: In Silico Guided Co-Amorphous Rifampicin–Moxifloxacin and –Ethambutol Formulations

Pharmaceutics
Background/Objectives: Tuberculosis (TB) remains a global health challenge due to long treatment durations, poor adherence, and growing drug resistance. Inhalable co-amorphous systems (COAMS) offer a promising strategy for targeted pulmonary delivery of ...
Eleonore Fröhlich, Noon Sharafeldin, Valerie Reinisch, Nila Mohsenzada, Stefan Mitsche, Hartmuth Schröttner, Sarah Zellnitz-Neugebauer   +6 more
doaj   +1 more source

Properties of Therapeutic Deep Eutectic Solvents of l-Arginine and Ethambutol for Tuberculosis Treatment

Molecules, 2018
The treatment for tuberculosis infection usually involves a prolonged regimen of multiple antibacterial drugs, which might lead to various secondary effects.
Filipa Santos, Maria Inês P.S. Leitão, Ana Rita C. Duarte   +2 more
doaj   +1 more source

Comparative Clinical Efficacy and Safety of Multi‐Segment Thoracolumbar Tuberculosis Treated Through the Posterior “Detour Method” Versus the Combined Anterior–Posterior Approach: A Technique Note and Preliminary Retrospective Study

Orthopaedic Surgery, EarlyView.
A simple schematic diagram; the red dashed arrow indicates the direction of surgical decompression. ABSTRACT Objective With the progress of spinal tuberculosis treatment theory and surgical tools, how to further improve the surgical efficacy, reduce surgical trauma, and increase safety in multi‐segmental spinal tuberculosis is still controversial ...
Dian Zhong, Wei Zeng, Guosheng Zhao, Yu Du, Yang Wang, Zhenyong Ke   +5 more
wiley   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Development of a Nafion/MWCNT-SPCE-Based Portable Sensor for the Voltammetric Analysis of the Anti-Tuberculosis Drug Ethambutol

Sensors, 2016
Herein we describe the development, characterization and application of an electrochemical sensor based on the use of Nafion/MWCNT-modified screen-printed carbon electrodes (SPCEs) for the voltammetric detection of the anti-tuberculosis (anti-TB) drug ...
Rosa A. S. Couto, Maria Beatriz Quinaz
doaj   +1 more source

Genetic polymorphism related to ethambutol outcomes and susceptibility to toxicity

Frontiers in Genetics, 2023
The World Health Organization (WHO) stated that ensuring access to effective and optimal treatment is a key component to eradicate tuberculosis (TB) through the End TB Strategy.
Melisa Intan Barliana, Melisa Intan Barliana, Nadiya Nurul Afifah, Vycke Yunivita, Rovina Ruslami   +4 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Development and characterisation of lyophilised ethambutol-loaded polymeric nanoparticles

Journal of Applied Pharmaceutical Research
Background: Tuberculosis (TB) remains a universal health crisis, requiring innovative drug delivery systems to overcome challenges like prolonged treatment duration and patient non-adherence.
Eknath Kole, Yogesh Sonar, Rahul J. Sarode, Atul Chaudhari, Jitendra Naik   +4 more
doaj   +1 more source

Clinical Images: A thorn injury, a sea‐borne culprit, and a tenosynovitis dilemma

Arthritis &Rheumatology, EarlyView.
Jacopo Ciaffi, Francesco Mori, Paolo Sassu, Marco Gambarotti, Alberto Righi, Eleonora Zamparini, Marco Innocenti, Marina Tadolini, Francesco Ursini   +8 more
wiley   +1 more source