Frontiers in Microbiology, 2021 Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH.
Kun Li +6 more
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Role of pncA and rpsA Gene Sequencing in Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates from Southern China [PDF]
Journal of Clinical Microbiology, 2013 ABSTRACT We sequenced pncA and rpsA genes plus flanking regions of 161 Mycobacterium tuberculosis isolates and found 10 new pncA and 3 novel rpsA mutations in pyrazinamide-resistant strains determined by the ...
Yaoju Tan +10 more
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"Caracterização molecular de mutações no gene pncA de isolados clínicos de Mycobacterium tuberculosis de origem brasileira" [PDF]
, 2004 Patricia Barco
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Journal of Clinical Microbiology and Infectious Diseases, 2022 ABSTRACT Introduction: Pyrazinamide (PZA) is one of the potent front-line drugs that act as antituberculosis (antiTB) for nonresistant or resistant Mycobacterium tuberculosis. Mutation of pncA gene is considered to be main target of PZA resistance mechanism.
Titiek Sulistyowati +2 more
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Validation of pncA Gene Sequencing in Combination with the Mycobacterial Growth Indicator Tube Method To Test Susceptibility of Mycobacterium tuberculosis to Pyrazinamide [PDF]
Journal of Clinical Microbiology, 2011 ABSTRACT Pyrazinamide is important in the treatment of tuberculosis. Unfortunately, the diagnosis of pyrazinamide resistance is hampered by technical difficulties. We hypothesized that mutation analysis combined with the mycobacterial growth indicator tube (MGIT) phenotypic method would be a good predictor of pyrazinamide ...
Sami O. Simons +6 more
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RASAYAN Journal of Chemistry, 2023 Pyrazinamide (PZA) is one of the anti-tuberculosis (TB) drugs that have an action on the pncA gene encoding the PZase enzyme. Mycobacterium tuberculosis clinical isolates R14 and R7 showed PZA resistance up to doses 40 and 30 µg/mL, however, the basis of their resistance was unknown.
S. Hadi +5 more
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Current Issues in Molecular Biology, 2022 Without the proper information on pyrazinamide (PZA) susceptibility of Mycobacterium tuberculosis (MTB), PZA is inappropriately recommended for the treatment of both susceptible and multidrug-resistant tuberculosis (MDR-TB) in Nepal.
Dipti Shrestha +7 more
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Rapid colorimetric testing for pyrazinamide susceptibility of M. tuberculosis by a PCR-based in-vitro synthesized pyrazinamidase method. [PDF]
PLoS ONE, 2011 Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug. But PZA susceptibility test is challenging because PZA activity is optimal only in an acid environment that inhibits the growth of M. tuberculosis.
Man Zhou +9 more
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INSERSI GEN pncA KE DALAM PLASMID pGEM-T
Jurnal Kimia Riset, 2016 . Multidrug-resistant tuberculosis (MDR-TB) is among the most worrisome elements of the pandemic of antibiotic resistance. As the first line drug, pyrazinamide is often used to treat TB desease so there are many case of TB resistant to pyrazinamide. The
Eli Hendrik Sanjaya
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Molecular Identification of Mutations Associated with Pyrazinamide-Resistance in Multidrug-Resistant Tuberculosis in Eight Provinces of Iran [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Multidrug-Resistant Tuberculosis (MDR-TB) is a growing concern which has always played a role in controlling infectious diseases. Pyrazinamide (PZA) is one of the four front line cures of tuberculosis during the first two months of the ...
Jila Moradi +5 more
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