Results 61 to 70 of about 2,353 (181)

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Weight cycling in Humans is suspected to dysregulate eating behavior. Mice submitted to body weight cycling by alternating western‐type and regular chow diets display increased hedonic appetite when exposed to a palatable diet, reminiscent of binge‐eating episodes.
Mélanie Fouesnard, Adélie Salin, Sandy Ribes, Magali Monnoye, Gaëlle Champeil‐Potokar, Marie‐Sabelle Hjeij, Gwénaëlle Randuineau, Léa Le Gleau, Selma Ben Fradj, Catherine Philippe, Alexandre Benani, Isabelle Denis, Véronique Douard, Gaëlle Boudry   +13 more
wiley   +1 more source

Evolutionary Genetic Analysis of the Pyrazinamidase Gene in Seven Global Populations of Mycobacterium tuberculosis

International Journal of Mycobacteriology
Background: This study aims to identify the signatures of natural selection in the pyrazinamidase (pncA) gene to see if genetic adaptations by Darwinian natural selection have shaped genetic composition of Mycobacterium tuberculosis (Mtb).
Neha Kumari, Nikhat Khan, Aparup Das
doaj   +1 more source

Screening mutations in drug-resistant Mycobacterium tuberculosis strains in Yunnan, China

Journal of Infection and Public Health, 2017
Drug-resistant tuberculosis (DR-TB), especially multidrug-resistant tuberculosis (MDR-TB), is a serious medical and societal problem in China. The purpose of this study was to evaluate the mutation characteristics of drug-resistant Mycobacterium ...
Daoqun Li, Yuzhu Song, Cheng-Lin Zhang, Xiaofei Li, Xueshan Xia, A-Mei Zhang   +5 more
doaj   +1 more source

Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors.

PLoS ONE, 2020
BackgroundPyrazinamide is an important drug against the latent stage of tuberculosis and is used in both first- and second-line treatment regimens.
Rydberg Roman Supo-Escalante, Aldhair Médico, Eduardo Gushiken, Gustavo E Olivos-Ramírez, Yaneth Quispe, Fiorella Torres, Melissa Zamudio, Ricardo Antiparra, L Mario Amzel, Robert H Gilman, Patricia Sheen, Mirko Zimic   +11 more
doaj   +1 more source

An assessment of a multiplex PCR assay for differentiating clinically important mycobacteria based on pncA gene variation

Molecular and Cellular Probes, 2003
The pncA genes in mycobacteria are responsible for the production of pyrazinamidase (PZase). In Mycobacterium tuberculosis, PZase hydrolyses pyrazinamide (PZA) to pyrazonic acid, a compound that possesses bactericidal activity against tubercle bacilli. Nucleotide sequences of pncA genes found within mycobacteria where aligned in an effort to ascertain ...
Mohammad S, Bamaga, David J, Wright, Hongyi, Zhang   +2 more
openaire   +2 more sources

Characterization of the Nicotinamide Adenine Dinucleotide Biosynthesis Pathway and Regulatory Mechanisms in Streptococcus mutans

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
This research elucidates NAD+ biosynthesis in Streptococcus mutans, revealing reliance on the nicotinic acid salvage pathway and an incomplete PnuC–NadR route. SmNiaR, a nicotinic acid‐responsive transcriptional regulator, orchestrates the transcriptional regulation of this pathway.
Haojie Yu, Dandan Shao, Yuheng Zhao, Shuojie Lv, Ruoxi Tao, Yu Sang, Jie Ren, Paul R Cooper, Qingjing Wang   +8 more
wiley   +1 more source

The pncA gene from naturally pyrazinamide-resistant Mycobacterium avium encodes pyrazinamidase and confers pyrazinamide susceptibility to resistant M. tuberculosis complex organisms [PDF]

Microbiology, 1997
The antituberculosis drug pyrazinamide (PZA) needs to be converted into pyrazinoic acid (POA) by the bacterial pyrazinamidase (PZase) in order to show bactericidal activity against Mycobacterium tuberculosis. M. avium is naturally resistant to PZA. To investigate whether this natural resistance to PZA is due to inability of the M.
Zhonghe, Sun, Angelo, Scorpio, Ying, Zhang   +2 more
openaire   +2 more sources

The Recent Development in the Diagnosis of Mycobacterium tuberculosis

Smart Medicine, Volume 4, Issue 2, June 2025.
Mycobacterium tuberculosis (MTB) remains a major global health challenge due to slow, low‐sensitivity traditional diagnostics. Rapid, highly sensitive point‐of‐care tests are critical for timely diagnosis and treatment, reducing transmission. This study reviews the evolution of MTB diagnostic tests, emphasizing advancements and addressing accessibility
Nimet Temur, Esma Eryilmaz‐ Eren, Ilhami Celik, Ilknur E. Yıldız, Mustafa Nisari, Ilay S. Unal, Cagla Celik, Nilay Ildiz, Ismail Ocsoy   +8 more
wiley   +1 more source

Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand

Journal of Infection in Developing Countries, 2020
Introduction: Multidrug-resistant tuberculosis (MDR-TB) is commonly found in Thailand especially in the public health region 5, the Western region of Thailand.
Krairerk Suthum, Worada Samosornsuk, Seksun Samosornsuk   +2 more
doaj   +1 more source