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Results 71 to 80 of about 2,353 (181)

Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis. [PDF]

PLoS ONE, 2017
Amplicon-based Next Generation Sequencing (NGS) is an emerging method for Mycobacterium tuberculosis drug susceptibility testing (DST) but has not been well described. We examined 158 clinical multidrug-resistant M.
Darwin J Operario +12 more
doaj +1 more source

Inorganic Metal Nanoparticles in Reproductive Biology: Applications, Toxicities and Future Prospects

ChemPlusChem, Volume 90, Issue 5, May 2025.
Metal nanoparticles (MNPs) have shown great promise in the livestock industry such as semen collection, nano‐purification, cryopreservation, sex sorting, bioimaging, drug and gene delivery. However, reproductive toxicity induced by MNP has adverse effects on various sexual functions including poor sperm parameters, testicular damage, ovary injury, and ...
Sangita Kundu +3 more
wiley +1 more source

BCG lymphadenopathy detected in a BCG-vaccinated infant

Brazilian Journal of Medical and Biological Research, 2004
Large-scale vaccination with BCG, the live attenuated strain of Mycobacterium bovis, is being adopted around the world, although sporadic complications have occurred after the procedure. Lymphadenopathy is not uncommon especially in babies under one year
A.S. Barouni +5 more
doaj +1 more source

Activation and inhibition of sirtuins: From bench to bedside

Medicinal Research Reviews, Volume 45, Issue 2, Page 484-560, March 2025.
Abstract The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic stability and gene expression and control key processes, including energetic metabolism, cell cycle, differentiation, apoptosis, and aging.
Francesco Fiorentino +3 more
wiley +1 more source

DNLA Delayed the Appearance of Learning and Memory Impairment of APP/PS1 Mice: Involvement of mTOR/TFEB/v‐ATPase Signaling Pathway

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
The article unraveled that preventive administration of DNLA may delay the impairment of learning and memory in APP/PS1 mice. The molecular mechanism may be related to promoting the mTOR‐TFEB‐v‐ATPase pathway. ABSTRACT Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive impairment that currently is incurable.
Yajuan Wu +6 more
wiley +1 more source

Cis‐Regulation of an m6A Eraser by an Insertion Variant Associated with Survival of Patients With Non‐Small Cell Lung Carcinoma

Advanced Science, Volume 12, Issue 5, February 3, 2025.
A common insertion variant exhibits cis‐regulation potential for the m6A eraser ALKBH5, which demethylates FBXL5 mRNA, leading to reduction in reactive oxygen species levels, inhibition of PI3K/AKT and NF‐kB pathways, and consequent suppression of NSCLC cells.
Lei Cheng +11 more
wiley +1 more source

Phylogenetic conservatism in the relationship between functional and demographic characteristics in Amazon tree taxa

Functional Ecology, Volume 39, Issue 1, Page 181-198, January 2025.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Leaf and wood functional traits of trees are related to growth, reproduction, and survival, but the degree of phylogenetic conservatism in these relationships is largely unknown.
Pablo Sanchez‐Martinez +214 more
wiley +1 more source

A Global Perspective on Pyrazinamide Resistance: Systematic Review and Meta-Analysis.

PLoS ONE, 2015
BackgroundPyrazinamide (PZA) is crucial for tuberculosis (TB) treatment, given its unique ability to eradicate persister bacilli. The worldwide burden of PZA resistance remains poorly described.MethodsSystematic PubMed, Science Direct and Scopus searches
Michael G Whitfield +7 more
doaj +1 more source

In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice. [PDF]

PLoS Pathogens, 2013
Analysis of the transcriptome of Borrelia burgdorferi, the causative agent of Lyme disease, during infection has proven difficult due to the low spirochete loads in the mammalian tissues.
Tisha Choudhury Ellis +8 more
doaj +1 more source

Epidemiological Profile and rpoB Gene Mutations in Pulmonary Tuberculosis Patients From Sulaymaniyah, Iraq: Evidence of Novel Genetic Variations and Beijing Lineage Emergence

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global public health concern, including in Iraq. This study investigated the epidemiology, molecular characteristics, and rifampicin resistance–associated mutations of pulmonary TB in Sulaymaniyah, Iraq, from May 2024 to May 2025.
Sirwan Mohammed Radha +3 more
wiley +1 more source

mycobacterium tuberculosis
tuberculosis
pyrazinamide

medicine
biology
pathology

genetics
gene
microbiology